General Information of the Compound
Compound ID
CP0036600
Compound Name
3-chloro-2-(5-chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)pyrimidin-4-ylamino)-N-methylbenzamide
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Structure
Formula
C24H24Cl2N6O2
Molecular Weight
499.402
Canonical SMILES
CNC(=O)c1cccc(Cl)c1Nc1nc(Nc2ccc3NC(=O)CCC(C)(C)c3c2)ncc1Cl
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InChI
InChI=1S/C24H24Cl2N6O2/c1-24(2)10-9-19(33)30-18-8-7-13(11-15(18)24)29-23-28-12-17(26)21(32-23)31-20-14(22(34)27-3)5-4-6-16(20)25/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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InChIKey
CXVYNVKRAHOLMU-UHFFFAOYSA-N
Physicochemical Property
logP
5.6401
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
108.04
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53325517
ChEMBL ID
CHEMBL1644806
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01201, Hepatocyte growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000282 GTL-16 Homo sapiens (Human)  1
1
IC50 = 1652 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 159 nM