General Information of the Compound
Compound ID
CP0016620
Compound Name
3-amino-6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]-N-methylpyrazine-2-carboxamide
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Structure
Formula
C20H23N5O2
Molecular Weight
365.437
Canonical SMILES
CNC(=O)c1nc(cnc1N)-c1cc2CN([C@@H](C)C3CC3)C(=O)c2c(C)c1
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InChI
InChI=1S/C20H23N5O2/c1-10-6-13(15-8-23-18(21)17(24-15)19(26)22-3)7-14-9-25(20(27)16(10)14)11(2)12-4-5-12/h6-8,11-12H,4-5,9H2,1-3H3,(H2,21,23)(H,22,26)/t11-/m0/s1
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InChIKey
ZXWFXYNECDHLJA-NSHDSACASA-N
Physicochemical Property
logP
2.14812
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
101.21
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145961182
ChEMBL ID
CHEMBL4130021
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03071, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000014 RAW 264.7 Mus musculus (Mouse)  1
1
IC50 = 398.11 nM
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