General Information of the Compound
Compound ID
CP0014364
Compound Name
(E)-3-[4-(1-cyclopropylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]prop-2-enamide
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Structure
Formula
C25H27N5O2
Molecular Weight
429.524
Canonical SMILES
O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1
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InChI
InChI=1S/C25H27N5O2/c31-25(28-22-4-1-19(2-5-22)17-29-11-13-32-14-12-29)8-3-20-15-26-10-9-24(20)21-16-27-30(18-21)23-6-7-23/h1-5,8-10,15-16,18,23H,6-7,11-14,17H2,(H,28,31)/b8-3+
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InChIKey
GADFZYLJRACWPZ-FPYGCLRLSA-N
Physicochemical Property
logP
3.7641
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
72.28
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 126568463
ChEMBL ID
CHEMBL4092865
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01975, Cyclin-dependent kinase 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
EC50 = 11 nM
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