General Information of the Compound
| Compound ID |
CP0010999
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| Compound Name |
4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide
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| Synonyms |
Benzene sulfonamide derivative 16
Nav1.7 blockers (pain), Pfizer
PF-05089771
PMID27414413-Compound-Figure3upright
SCN9A blockers (pain), Pfizer/Icagen/Birkbeck
Voltage-gated sodium channel 1.7 blockers (pain), Pfizer
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| Structure |
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| Formula |
C18H12Cl2FN5O3S2
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| Molecular Weight |
500.364
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| Canonical SMILES |
Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
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| InChI |
InChI=1S/C18H12Cl2FN5O3S2/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17/h1-8,26H,(H3,22,24,25)
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| InChIKey |
ZYSCOUXLBXGGIM-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02267, Sodium channel protein type 1 subunit alpha
Protein ID: PT02752, Sodium channel protein type 10 subunit alpha
Protein ID: PT03022, Sodium channel protein type 2 subunit alpha
Protein ID: PT03042, Sodium channel protein type 3 subunit alpha
Protein ID: PT03043, Sodium channel protein type 4 subunit alpha
Protein ID: PT01105, Sodium channel protein type 5 subunit alpha
Protein ID: PT03581, Sodium channel protein type 8 subunit alpha
Protein ID: PT01000, Sodium channel protein type 9 subunit alpha
Protein ID: PT04404, Sodium channel protein type 9 subunit alpha
Protein ID: PT03073, Solute carrier family 22 member 12
Clinical Information about the Compound
Drug 1 ( Benzene sulfonamide derivative 16 )
| Drug Name | Benzene sulfonamide derivative 16 | ||
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| Company | PFIZER LIMITED | ||
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