Brief Information of the Cell Line and Protein
Cell Line ID: CL001020 , EE-HEK293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT00983 , Kappa-type opioid receptor
Gene Name OPRK1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P41145
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL001020  Protein ID: PT00983
 
Compound ID Compound Name Compound Formula
CP0040101
2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
   Show/Hide
C19H26Cl2N2O
 1
1
EC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0535577
3-[(1R,9R,13R)-4-hydroxy-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-yl]-N-naphthalen-1-ylpropanamide
   Show/Hide
C27H30N2O2
 2
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 800 nM
   TI
   LI
   LO
   TS
CP0377132
3-[(1R,9R,13R)-4-hydroxy-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-yl]-N-quinolin-8-ylpropanamide
   Show/Hide
C26H29N3O2
 1
1
Ki = 230 nM
   TI
   LI
   LO
   TS
CP0377133
3-[(1R,9R,13R)-4-hydroxy-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-yl]-N-quinolin-5-ylpropanamide
   Show/Hide
C26H29N3O2
 1
1
Ki = 1540 nM
   TI
   LI
   LO
   TS
CP0448061
3-[(1R,9R,13R)-4-hydroxy-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-yl]-N-isoquinolin-5-ylpropanamide
   Show/Hide
C26H29N3O2
 1
1
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0448060
3-[(1R,9R,13R)-4-hydroxy-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-yl]-N-quinolin-6-ylpropanamide
   Show/Hide
C26H29N3O2
 1
1
Ki = 4400 nM
   TI
   LI
   LO
   TS
CP0377134
3-[(1R,9R,13R)-4-hydroxy-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-yl]-N-quinolin-3-ylpropanamide
   Show/Hide
C26H29N3O2
 1
1
Ki = 6470 nM
   TI
   LI
   LO
   TS
CP0386984
3-[(1R,9R,13R)-4-hydroxy-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-yl]-N-phenylpropanamide
   Show/Hide
C23H28N2O2
 1
1
Ki = 7500 nM
   TI
   LI
   LO
   TS