Brief Information of the Cell Line and Protein
Cell Line ID: CL001016 , HEKMSR2
Synonyms
HEK293-MSRII,HEKMSRII
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_6643
Protein ID: PT04958 , Short transient receptor potential channel 6
Gene Name TRPC6
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID Q9Y210
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL001016  Protein ID: PT04958
 
Compound ID Compound Name Compound Formula
CP0522694
[5-chloro-2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone
   Show/Hide
C18H19ClFN3O3S
 1
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
CP0087710
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2S,3S)-2,3-dimethylpiperidin-1-yl]methanone
   Show/Hide
C18H21ClFN3OS
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0476517
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone
   Show/Hide
C18H21N3O3S
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0397505
(2,3-dimethylpiperidin-1-yl)-[2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-5-methyl-1,3-thiazol-4-yl]methanone
   Show/Hide
C19H22FN3O3S
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0407559
[2-(1,3-benzodioxol-5-ylamino)-5-methyl-1,3-thiazol-4-yl]-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methanone
   Show/Hide
C22H21N3O3S
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0906685
rac-N-(2-fluoro-4-chlorophenyl)-4-[(2,3-dimethyl-1-piperidinyl)carbonyl]-1,3-(5-methyl)thiazol-2-amine
   Show/Hide
C18H21ClFN3OS
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0433281
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methanone
   Show/Hide
C21H19N3O3S
 1
1
IC50 = 63 nM
   TI
   LI
   LO
   TS
CP0227780
(2,3-dimethylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone
   Show/Hide
C18H23N3OS
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0483017
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(3,4-dihydro-1H-isoquinolin-2-yl)methanone
   Show/Hide
C20H17N3O3S
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0500911
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C17H19N3O3S
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0476516
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C17H21N3OS
 1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CP0479031
3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone
   Show/Hide
C20H19N3O2S
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0397507
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(2-methylpiperidin-1-yl)methanone
   Show/Hide
C17H21N3OS
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0397508
[2-(4-chloro-2-fluoroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C16H17ClFN3OS
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0397509
[2-(4-methoxyanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C17H21N3O2S
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0397638
[2-(4-chloroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C16H18ClN3OS
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0397639
[2-(1,3-benzodioxol-5-ylamino)-5-methyl-1,3-thiazol-4-yl]-(5-methyl-7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone
   Show/Hide
C21H20N4O3S
 1
1
IC50 = 1260 nM
   TI
   LI
   LO
   TS
CP0407560
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2R,3R)-2,3-dimethylpiperidin-1-yl]methanone
   Show/Hide
C18H21ClFN3OS
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0483021
[2-(4-methoxyanilino)-1,3-thiazol-4-yl]-(4-phenylpiperidin-1-yl)methanone
   Show/Hide
C22H23N3O2S
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0476515
[2-(2-chloroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C16H18ClN3OS
 1
1
IC50 = 3160 nM
   TI
   LI
   LO
   TS
CP0483019
(4-cyclohexylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone
   Show/Hide
C22H29N3OS
 1
1
IC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0504718
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-(7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone
   Show/Hide
C19H16ClFN4OS
 1
1
IC50 = 6300 nM
   TI
   LI
   LO
   TS
CP0433283
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(2-phenylpiperidin-1-yl)methanone
   Show/Hide
C22H23N3OS
 1
1
IC50 = 15800 nM
   TI
   LI
   LO
   TS
CP0397506
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(3-phenylpiperidin-1-yl)methanone
   Show/Hide
C22H23N3OS
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS