Brief Information of the Cell Line and Protein
Cell Line ID: CL000881 , P2X7-1321N1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0110
Protein ID: PT03917 , P2X purinoceptor 7
Gene Name P2RX7
Organism Rattus norvegicus, Rat
Protein Classification Ion channel
Uniprot ID Q64663
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000881  Protein ID: PT03917
 
Compound ID Compound Name Compound Formula
CP0385599
BDBM160086
   Show/Hide
C18H14ClF3N6O
 1
1
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0417275
US10047092, 32
   Show/Hide
C17H13ClF3N5OS
 1
1
Ki = 0.4 nM
   TI
   LI
   LO
   TS
CP0877279
US9040534, 26
   Show/Hide
C18H16ClF3N6O
 1
1
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0863273
US9096596, 89
   Show/Hide
C19H17ClFN5O
 1
1
Ki = 1 nM
   TI
   LI
   LO
   TS
CP0056677
US10047092, 16
   Show/Hide
C18H14ClF3N6O
 1
1
Ki = 1.1 nM
   TI
   LI
   LO
   TS
CP0407681
US10053462, 8
   Show/Hide
C19H15ClF3N5OS
 1
1
Ki = 1.3 nM
   TI
   LI
   LO
   TS
CP0380496
US10047092, 76
   Show/Hide
C20H16ClF4N5O
 1
1
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CP0403649
US10047092, 75
   Show/Hide
C19H15ClF4N6O
 1
1
Ki = 1.8 nM
   TI
   LI
   LO
   TS
CP0903792
US9096596, 84
   Show/Hide
C19H17Cl2N5O
 1
1
Ki = 1.9 nM
   TI
   LI
   LO
   TS
CP0385042
US10047092, 18
   Show/Hide
C19H15ClF3N5O
 1
1
Ki = 2 nM
   TI
   LI
   LO
   TS
CP0846069
US9040534, 28
   Show/Hide
C17H14ClF3N6O
 1
1
Ki = 2 nM
   TI
   LI
   LO
   TS
CP0384906
US10047092, 34
   Show/Hide
C18H13ClF4N6O
 1
1
Ki = 2.8 nM
   TI
   LI
   LO
   TS
CP0879023
US9096596, 58
   Show/Hide
C20H17ClF3N5O
 1
1
Ki = 2.8 nM
   TI
   LI
   LO
   TS
CP0487017
US10323032, Example 128
   Show/Hide
C23H23ClF3N5O2
 1
1
Ki = 3 nM
   TI
   LI
   LO
   TS
CP0408299
US10047092, 23
   Show/Hide
C18H16ClF3N6O
 1
1
Ki = 3.2 nM
   TI
   LI
   LO
   TS
CP0400904
US10053462, 33
   Show/Hide
C21H17ClF3N5O
 1
1
Ki = 3.2 nM
   TI
   LI
   LO
   TS
CP0396418
US10053462, 12
   Show/Hide
C21H16ClF4N5O
 1
1
Ki = 3.4 nM
   TI
   LI
   LO
   TS
CP0484511
US10047092, 21
   Show/Hide
C17H13ClF3N5O2
 1
1
Ki = 3.5 nM
   TI
   LI
   LO
   TS
CP0385544
US10323032, Example 124
   Show/Hide
C22H20ClF4N5O
 1
1
Ki = 3.5 nM
   TI
   LI
   LO
   TS
CP0440539
US10323032, Example 20
   Show/Hide
C17H12Cl2FN5O
 1
1
Ki = 3.5 nM
   TI
   LI
   LO
   TS
CP0375035
US10053462, 3
   Show/Hide
C20H16ClF3N6O
 1
1
Ki = 4 nM
   TI
   LI
   LO
   TS
CP0397123
US10053462, 49
   Show/Hide
C18H13ClF3N5OS
 1
1
Ki = 4 nM
   TI
   LI
   LO
   TS
CP0524252
US10053462, 26
   Show/Hide
C22H19ClF3N5O2
 1
1
Ki = 4 nM
   TI
   LI
   LO
   TS
CP0375375
US10047092, 17
   Show/Hide
C20H15ClF4N4O
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0381007
US10047092, 30
   Show/Hide
C19H14ClF4N5O
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0407689
US10047092, 20
   Show/Hide
C17H13ClF3N5O2
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0527398
US10047092, 45
   Show/Hide
C19H14ClF4N5O
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0469296
US10323032, Example 18
   Show/Hide
C18H13ClF3N5O
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0473488
US10053462, 23
   Show/Hide
C22H19ClF3N5O
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0385598
US10047092, 29
   Show/Hide
C19H15ClF3N5O
 1
1
Ki = 5.6 nM
   TI
   LI
   LO
   TS
CP0429645
US10047092, 19
   Show/Hide
C19H16ClF3N6O
 1
1
Ki = 6.3 nM
   TI
   LI
   LO
   TS
CP0388923
US10053462, 47
   Show/Hide
C18H13Cl2FN6O
 1
1
Ki = 6.3 nM
   TI
   LI
   LO
   TS
CP0407838
US10053462, 52
   Show/Hide
C18H12ClF4N5OS
 1
1
Ki = 6.3 nM
   TI
   LI
   LO
   TS
CP0541397
US10053462, 46
   Show/Hide
C19H14ClF3N6O
 1
1
Ki = 6.3 nM
   TI
   LI
   LO
   TS
CP0384797
US10053462, 41
   Show/Hide
C20H15ClF3N5O
 1
1
Ki = 7.9 nM
   TI
   LI
   LO
   TS
CP0414717
US10053462, 42
   Show/Hide
C19H14ClF3N6O
 1
1
Ki = 7.9 nM
   TI
   LI
   LO
   TS
CP0456491
US10053462, 53
   Show/Hide
C19H16F3N5OS
 1
1
Ki = 7.9 nM
   TI
   LI
   LO
   TS
CP0487012
US10053462, 54
   Show/Hide
C17H12Cl2FN5OS
 1
1
Ki = 7.9 nM
   TI
   LI
   LO
   TS
CP0863244
US9102686, 51
   Show/Hide
C19H16ClF3N6O
 1
1
Ki = 7.9 nM
   TI
   LI
   LO
   TS
CP0403003
US10323032, Example 43
   Show/Hide
C18H12ClF3N4OS
 1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CP0420624
US10053462, 50
   Show/Hide
C19H13ClF4N6O
 1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CP0403398
US10323032, Example 33
   Show/Hide
C19H15ClF3N5O
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
CP0539442
US10047092, 3
   Show/Hide
C17H12ClF3N6O
 1
1
Ki = 12.6 nM
   TI
   LI
   LO
   TS
CP0406949
US10323032, Example 35
   Show/Hide
C19H14ClF4N5O
 1
1
Ki = 12.6 nM
   TI
   LI
   LO
   TS
CP0385779
US10053462, 44
   Show/Hide
C21H18F3N5O
 1
1
Ki = 12.6 nM
   TI
   LI
   LO
   TS
CP0422523
US10053462, 43
   Show/Hide
C20H14ClF4N5O
 1
1
Ki = 13.8 nM
   TI
   LI
   LO
   TS
CP0407563
US10323032, Example 7
   Show/Hide
C17H13Cl2N5O
 1
1
Ki = 14.5 nM
   TI
   LI
   LO
   TS
CP0407675
US10053462, 48
   Show/Hide
C20H15ClF3N5O
 1
1
Ki = 15.8 nM
   TI
   LI
   LO
   TS
CP0474346
US10053462, 55
   Show/Hide
C19H13Cl2F3N4OS
 1
1
Ki = 15.8 nM
   TI
   LI
   LO
   TS
CP0385776
US10047092, 92
   Show/Hide
C18H18N6O
 1
1
Ki = 16.4 nM
   TI
   LI
   LO
   TS
CP0388932
US10323032, Example 39
   Show/Hide
C20H14ClF6N5O
 1
1
Ki = 17.8 nM
   TI
   LI
   LO
   TS
CP0411397
US10323032, Example 34
   Show/Hide
C18H15Cl2N5O
 1
1
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0385144
US10323032, Example 10
   Show/Hide
C19H16F3N5O
 1
1
Ki = 21.9 nM
   TI
   LI
   LO
   TS
CP0460008
US10047092, 22
   Show/Hide
C17H13ClF3N5O2
 1
1
Ki = 25.1 nM
   TI
   LI
   LO
   TS
CP0524278
US10323032, Example 37
   Show/Hide
C18H12ClF3N4OS
 1
1
Ki = 25.1 nM
   TI
   LI
   LO
   TS
CP0385627
US10047092, 93
   Show/Hide
C19H16ClF3N6O
 1
1
Ki = 31.6 nM
   TI
   LI
   LO
   TS
CP0385845
US10323032, Example 14
   Show/Hide
C18H13Cl2N5O
 1
1
Ki = 31.6 nM
   TI
   LI
   LO
   TS
CP0516657
US10323032, Example 36
   Show/Hide
C18H14Cl2FN5O
 1
1
Ki = 31.6 nM
   TI
   LI
   LO
   TS
CP0407607
US10053462, 45
   Show/Hide
C20H14ClF4N5O
 1
1
Ki = 31.6 nM
   TI
   LI
   LO
   TS
CP0407608
US10053462, 40
   Show/Hide
C21H15ClF4N4O
 1
1
Ki = 35.5 nM
   TI
   LI
   LO
   TS
CP0382526
US10323032, Example 38
   Show/Hide
C17H12Cl2N4OS
 1
1
Ki = 45.7 nM
   TI
   LI
   LO
   TS
CP0462690
US10323032, Example 15
   Show/Hide
C20H16F3N5O
 1
1
Ki = 50.1 nM
   TI
   LI
   LO
   TS
CP0305154
US10323032, Example 12
   Show/Hide
C20H14ClF3N4O
 1
1
Ki = 57.5 nM
   TI
   LI
   LO
   TS
CP0417817
US10323032, Example 11
   Show/Hide
C19H14Cl2N4O
 1
1
Ki = 61.7 nM
   TI
   LI
   LO
   TS
CP0411939
US10047092, 94
   Show/Hide
C18H18N6O
 1
1
Ki = 123 nM
   TI
   LI
   LO
   TS
CP0414028
US10323032, Example 2
   Show/Hide
C20H15Cl2N3O
 1
1
Ki = 251.2 nM
   TI
   LI
   LO
   TS