Brief Information of the Cell Line and Protein
Cell Line ID: CL000880 , COS
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0223
Protein ID: PT01197 , Type-1 angiotensin II receptor
Gene Name AGTR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P30556
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000880  Protein ID: PT01197
 
Compound ID Compound Name Compound Formula
CP0449141
3-(5,7-Dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-ylmethyl)-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one
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C28H25N7O
 1
1
Ki = 0.29 nM
   TI
   LI
   LO
   TS
CP0532731
3-(2-Cyclopropyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one
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C28H23N7O
 1
1
Ki = 0.45 nM
   TI
   LI
   LO
   TS
CP0476963
3-(2-Ethyl-6-methoxy-[1,5]naphthyridin-4-yloxymethyl)-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one
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C28H22N6O3
 1
1
Ki = 0.48 nM
   TI
   LI
   LO
   TS
CP0507237
5,7-Dimethyl-2-propyl-3-[11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethyl]-3H-imidazo[4,5-b]pyridine
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C28H27N7
 1
1
Ki = 0.49 nM
   TI
   LI
   LO
   TS
CP0384158
3-(2-Ethyl-quinolin-4-yloxymethyl)-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one
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C28H21N5O2
 1
1
Ki = 0.65 nM
   TI
   LI
   LO
   TS
CP0466031
3-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one
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C27H23N7O
 1
1
Ki = 0.66 nM
   TI
   LI
   LO
   TS
CP0395442
5,7-Dimethyl-2-propyl-3-[11-(1H-tetrazol-5-yl)-dibenzo[b,f]oxepin-3-ylmethyl]-3H-imidazo[4,5-b]pyridine
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C27H25N7O
 1
1
Ki = 0.7 nM
   TI
   LI
   LO
   TS
CP0488957
3-[(5-Ethyl-pyrazolo[1,5-a]pyrimidin-7-ylamino)-methyl]-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one
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C25H20N8O
 1
1
Ki = 1.1 nM
   TI
   LI
   LO
   TS
CP0498353
3-(2-Ethyl-5,6,7,8-tetrahydro-quinolin-4-yloxymethyl)-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one
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C28H25N5O2
 1
1
Ki = 1.3 nM
   TI
   LI
   LO
   TS
CP0453436
2-Butyl-5-chloro-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethyl]-3H-imidazole-4-carboxylic acid
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C25H21ClN6O3
 1
1
Ki = 2.1 nM
   TI
   LI
   LO
   TS
CP0463883
2-Ethyl-4-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethoxy]-quinoline-6-carboxylic acid
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C29H21N5O4
 1
1
Ki = 2.7 nM
   TI
   LI
   LO
   TS
CP0540251
2-Ethoxy-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethyl]-3H-benzoimidazole-4-carboxylic acid
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C27H20N6O4
 1
1
Ki = 2.7 nM
   TI
   LI
   LO
   TS
CP0544900
2,6-Dimethyl-4-{[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethyl]-amino}-nicotinic acid ethyl ester
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C27H24N6O3
 1
1
Ki = 2.9 nM
   TI
   LI
   LO
   TS
CP0448269
2-Ethoxy-3-[11-(1H-tetrazol-5-yl)-dibenzo[b,f]oxepin-3-ylmethyl]-3H-benzoimidazole-4-carboxylic acid
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C26H20N6O4
 1
1
Ki = 3.9 nM
   TI
   LI
   LO
   TS
CP0479908
2,6-Dimethyl-4-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethoxy]-nicotinic acid ethyl ester
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C27H23N5O4
 1
1
Ki = 4.3 nM
   TI
   LI
   LO
   TS
CP0544903
3-(2-Methyl-5,6,7,8-tetrahydro-quinolin-4-yloxymethyl)-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one
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C27H23N5O2
 1
1
Ki = 4.3 nM
   TI
   LI
   LO
   TS
CP0461038
(S)-3-Methyl-2-{[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethyl]-pentanoyl-amino}-butyric acid
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C27H29N5O4
 1
1
Ki = 8.7 nM
   TI
   LI
   LO
   TS
CP0448379
(S)-3-Methyl-2-{pentanoyl-[11-(1H-tetrazol-5-yl)-dibenzo[b,f]oxepin-3-ylmethyl]-amino}-butyric acid
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C26H29N5O4
 1
1
Ki = 9.6 nM
   TI
   LI
   LO
   TS
CP0468051
2-Butyl-5-chloro-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[a,d]cyclohepten-3-ylmethyl]-3H-imidazole-4-carbaldehyde
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C25H21ClN6O2
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS