Brief Information of the Cell Line and Protein
Cell Line ID: CL000870 , HEK-Blue Null1-v
Category Transformed cell line
Organism
Homo sapiens (Human)
Protein ID: PT02546 , Toll-like receptor 8
Gene Name TLR8
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q9NR97
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000870  Protein ID: PT02546
 
Compound ID Compound Name Compound Formula
CP0402385
1-(4-amino-2-butyl-7-chloroimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
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C18H23ClN4O
 1
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0473443
1-(4-amino-2-butyl-7-methoxyimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
   Show/Hide
C19H26N4O2
 1
1
EC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0233638
1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
   Show/Hide
C17H22N4O2
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0475421
4-amino-2-butyl-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carbonitrile
   Show/Hide
C19H23N5O
 1
1
EC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0541759
1-[4-amino-7-chloro-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
   Show/Hide
C17H21ClN4O2
 1
1
EC50 = 4900 nM
   TI
   LI
   LO
   TS
CP0475420
4-amino-2-(ethoxymethyl)-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carbonitrile
   Show/Hide
C18H21N5O2
 1
1
EC50 = 27000 nM
   TI
   LI
   LO
   TS
CP0153455
1-[(4-amino-1-ethyl-7-thiophen-2-ylimidazo[4,5-c]quinolin-2-yl)methyl]pyrrolidin-2-one
   Show/Hide
C21H21N5OS
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0153456
(4S)-1-[(4-amino-7-pyrazol-1-yl-3H-imidazo[4,5-c]quinolin-2-yl)methyl]-4-phenylpyrrolidin-2-one
   Show/Hide
C24H21N7O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0153457
N-[(4-amino-7-phenyl-3H-imidazo[4,5-c]quinolin-2-yl)methyl]-N-ethylacetamide
   Show/Hide
C21H21N5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0179168
N-[[4-amino-1-ethyl-7-(1H-pyrazol-5-yl)imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethylpropanamide
   Show/Hide
C21H25N7O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0188736
N-[[4-amino-7-(cyclopenten-1-yl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethylacetamide
   Show/Hide
C20H23N5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0188748
tert-butyl N-[[4-amino-1-methyl-7-(1H-pyrazol-5-yl)imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethylcarbamate
   Show/Hide
C22H27N7O2
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0238747
2-[[ethyl(methyl)amino]methyl]-7-(1H-pyrazol-5-yl)-3H-imidazo[4,5-c]quinolin-4-amine
   Show/Hide
C17H19N7
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0248004
1-[(4-amino-7-phenyl-3H-imidazo[4,5-c]quinolin-2-yl)methyl]pyrrolidin-2-one
   Show/Hide
C21H19N5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0271059
1-[(4-amino-7-thiophen-2-yl-3H-imidazo[4,5-c]quinolin-2-yl)methyl]pyrrolidin-2-one
   Show/Hide
C19H17N5OS
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0271061
1-[[4-amino-7-(3-methylphenyl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]pyrrolidin-2-one
   Show/Hide
C22H21N5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0389374
1-[[4-amino-7-(4-methylphenyl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]pyrrolidin-2-one
   Show/Hide
C22H21N5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0457356
1-[[4-amino-7-(2-fluorophenyl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]pyrrolidin-2-one
   Show/Hide
C21H18FN5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0473444
7-chloro-2-(ethoxymethyl)-1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
   Show/Hide
C17H21ClN4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0473445
4-amino-2-butyl-1-(2-methylpropyl)imidazo[4,5-c]quinoline-7-carbonitrile
   Show/Hide
C19H23N5
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0475418
4-amino-2-butyl-1-(2-methylpropyl)imidazo[4,5-c]quinolin-7-ol
   Show/Hide
C18H24N4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0475422
2-butyl-7-chloro-1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
   Show/Hide
C18H23ClN4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0520935
4-amino-2-(ethoxymethyl)-1-(2-methylpropyl)imidazo[4,5-c]quinoline-7-carbonitrile
   Show/Hide
C18H21N5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0520936
2-butyl-7-methoxy-1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
   Show/Hide
C19H26N4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0388424
2-[4-[2-(3,4-dimethoxyphenyl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
   Show/Hide
C27H37N3O2
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0010966
3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C15H21N3OS
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0440907
3-[5-methylsulfanyl-4-(3,4,5-trichlorophenyl)-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H12Cl3N3OS
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0459341
3-[4-(3,4-dichlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H13Cl2N3OS
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0574023
3-[5-methylsulfanyl-4-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C13H14F3N3OS
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0444831
3-[4-(2,4-dichlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H13Cl2N3OS
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0558316
3-[4-(3-methylphenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C13H17N3OS
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0440906
3-[4-(3-chlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H14ClN3OS
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0554769
3-[4-(2,4-dichlorophenyl)-5-ethylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C13H15Cl2N3OS
 1
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
CP0576186
3-(5-methylsulfanyl-4-naphthalen-1-yl-1,2,4-triazol-3-yl)propan-1-ol
   Show/Hide
C16H17N3OS
 1
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
CP0554760
5-[4-(2,4-dichlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]pentan-1-ol
   Show/Hide
C14H17Cl2N3OS
 1
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
CP0548357
[4-(2,4-dichlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]methanol
   Show/Hide
C10H9Cl2N3OS
 1
1
IC50 = 550 nM
   TI
   LI
   LO
   TS
CP0533250
2-[4-(2,4-dichlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]ethanol
   Show/Hide
C11H11Cl2N3OS
 1
1
IC50 = 590 nM
   TI
   LI
   LO
   TS
CP0459342
3-[5-methylsulfanyl-4-(2,3,4-trichlorophenyl)-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H12Cl3N3OS
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0575213
4-(2,4-dichlorophenyl)-3-methylsulfanyl-5-propyl-1,2,4-triazole
   Show/Hide
C12H13Cl2N3S
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0533251
3-[4-(2,3-dichlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H13Cl2N3OS
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0459340
3-[4-(2-chlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H14ClN3OS
 1
1
IC50 = 980 nM
   TI
   LI
   LO
   TS
CP0554759
4-[4-(2,4-dichlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]butan-1-ol
   Show/Hide
C13H15Cl2N3OS
 1
1
IC50 = 1060 nM
   TI
   LI
   LO
   TS
CP0554761
4-(2,4-dichlorophenyl)-3-(3-methoxypropyl)-5-methylsulfanyl-1,2,4-triazole
   Show/Hide
C13H15Cl2N3OS
 1
1
IC50 = 1180 nM
   TI
   LI
   LO
   TS
CP0548358
3-[4-(4-chlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H14ClN3OS
 1
1
IC50 = 1610 nM
   TI
   LI
   LO
   TS
CP0558315
3-[4-(2,4-dichlorophenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propyl acetate
   Show/Hide
C14H15Cl2N3O2S
 1
1
IC50 = 2080 nM
   TI
   LI
   LO
   TS
CP0539645
3-[5-methylsulfanyl-4-(2,4,6-trichlorophenyl)-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C12H12Cl3N3OS
 1
1
IC50 = 2810 nM
   TI
   LI
   LO
   TS
CP0524989
2-[3-(4-amino-1-benzylimidazo[4,5-c]quinolin-2-yl)propyl]-1-benzylimidazo[4,5-c]quinolin-4-amine
   Show/Hide
C37H32N8
 1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0576185
3-[4-(4-methoxyphenyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C13H17N3O2S
 1
1
IC50 = 3860 nM
   TI
   LI
   LO
   TS
CP0417283
2-[10-(4-amino-1-benzylimidazo[4,5-c]quinolin-2-yl)decyl]-1-benzylimidazo[4,5-c]quinolin-4-amine
   Show/Hide
C44H46N8
 1
1
IC50 = 4650 nM
   TI
   LI
   LO
   TS
CP0385681
N,N'-bis[[4-[(4-amino-2-butylimidazo[4,5-c]quinolin-1-yl)methyl]phenyl]methyl]dodecanediamide
   Show/Hide
C56H68N10O2
 1
1
IC50 = 4780 nM
   TI
   LI
   LO
   TS
CP0435788
3-[5-methylsulfanyl-4-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C13H14F3N3OS
 1
1
IC50 = 4840 nM
   TI
   LI
   LO
   TS
CP0440905
4-(2,4-dichlorophenyl)-3-methylsulfanyl-1H-1,2,4-triazol-5-one
   Show/Hide
C9H7Cl2N3OS
 1
1
IC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0459339
3-[4-(2,4-dichlorophenyl)-5-propan-2-ylsulfanyl-1,2,4-triazol-3-yl]propan-1-ol
   Show/Hide
C14H17Cl2N3OS
 1
1
IC50 = 10120 nM
   TI
   LI
   LO
   TS
CP0447821
2-[6-(4-amino-1-benzylimidazo[4,5-c]quinolin-2-yl)hexyl]-1-benzylimidazo[4,5-c]quinolin-4-amine
   Show/Hide
C40H38N8
 1
1
IC50 = 10920 nM
   TI
   LI
   LO
   TS
CP0417282
2-[4-(4-amino-1-benzylimidazo[4,5-c]quinolin-2-yl)butyl]-1-benzylimidazo[4,5-c]quinolin-4-amine
   Show/Hide
C38H34N8
 1
1
IC50 = 15630 nM
   TI
   LI
   LO
   TS
CP0368178
4-(2,4-dichlorophenyl)-3-(3-hydroxypropyl)-1H-1,2,4-triazole-5-thione
   Show/Hide
C11H11Cl2N3OS
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0435789
3-(4-cyclohexyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propan-1-ol
   Show/Hide
C12H21N3OS
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0444829
S-[[4-(2,4-dichlorophenyl)-5-(3-hydroxypropyl)-1,2,4-triazol-3-yl]] carbamothioate
   Show/Hide
C12H12Cl2N4O2S
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0520394
2-[[4-(2,4-dichlorophenyl)-5-(3-hydroxypropyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
   Show/Hide
C13H14Cl2N4O2S
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0576187
3-(5-methylsulfanyl-4-pyridin-3-yl-1,2,4-triazol-3-yl)propan-1-ol
   Show/Hide
C11H14N4OS
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS