Brief Information of the Cell Line and Protein
Cell Line ID: CL000752 , PBMC iPSC #1
Category Induced pluripotent stem cell
Organism
Homo sapiens (Human)
Protein ID: PT01214 , Tyrosine-protein kinase JAK2
Gene Name JAK2
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID O60674
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000752  Protein ID: PT01214
 
Compound ID Compound Name Compound Formula
CP0008918
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide
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C19H22N4O3S2
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0001781
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-methoxyethyl)thieno[3,2-c]pyridine-7-carboxamide
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C21H26N4O4S2
 1
1
IC50 = 135 nM
   TI
   LI
   LO
   TS
CP0001805
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-morpholin-4-ylethyl)thieno[3,2-c]pyridine-7-carboxamide
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C24H31N5O4S2
 1
1
IC50 = 148 nM
   TI
   LI
   LO
   TS
CP0002393
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
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C16H20N6O
 1
1
IC50 = 155 nM
   TI
   LI
   LO
   TS
CP0636232
DELGOCITINIB
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C16H18N6O
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0001071
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-[2-(dimethylamino)ethyl]thieno[3,2-c]pyridine-7-carboxamide
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C22H29N5O3S2
 1
1
IC50 = 515 nM
   TI
   LI
   LO
   TS
CP0009734
4-amino-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide
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C18H18N4O2S
 1
1
IC50 = 761 nM
   TI
   LI
   LO
   TS
CP0014588
US10196390, Compound I-136
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C21H17F2N5O2
 1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0011836
US10196390, Compound I-231
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C24H20F2N4O3
 1
1
IC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0014097
US10336752, Compound 1
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C24H20F2N4O2
 1
1
IC50 = 3900 nM
   TI
   LI
   LO
   TS