Brief Information of the Cell Line and Protein
Cell Line ID: CL000386 , Flp-In-CHO
Synonyms
Flp-In CHO
CHO Flp-In
CHO-Flp-In
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_U424
Protein ID: PT01278 , Adenosine receptor A2b
Gene Name ADORA2B
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P29275
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000386  Protein ID: PT01278
 
Compound ID Compound Name Compound Formula
CP0546140
[2-amino-5-[4-[1-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]triazol-4-yl]phenyl]-4-[3-(trifluoromethyl)phenyl]thiophen-3-yl]-phenylmethanone
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C42H40F3N9O5S
 1
1
EC50 = 0.3802 nM
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CP0039348
(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
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C12H16N6O4
 4
1
EC50 = 3.162 nM
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2
EC50 = 4.786 nM
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3
EC50 = 15.85 nM
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4
EC50 = 42.66 nM
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CP0394589
4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C41H40F3N7O6S
 2
1
EC50 = 4.571 nM
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2
EC50 = 95.5 nM
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CP0549807
4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[3-[4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]phenyl]propyl]benzamide
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C44H38F3N7O6S
 1
1
EC50 = 6.31 nM
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CP0389164
N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]-3-thiophen-2-ylbenzamide
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C27H32N6O5S
 1
1
EC50 = 17.78 nM
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CP0394595
4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[2-chloro-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C41H39ClF3N7O6S
 1
1
EC50 = 18.62 nM
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CP0018686
(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide
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C18H19IN6O4
 1
1
EC50 = 31.62 nM
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CP0408494
3-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C41H40F3N7O6S
 1
1
EC50 = 35.48 nM
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CP0041258
(CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmethyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid
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C23H29N7O6
 1
1
EC50 = 39.81 nM
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CP0546135
4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[2-[4-[2-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]ethyl]phenyl]ethyl]benzamide
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C45H40F3N7O6S
 1
1
EC50 = 52.48 nM
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CP0394587
3-(5-aminothiophen-2-yl)-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C27H33N7O5S
 1
1
EC50 = 60.26 nM
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CP0394585
4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[5-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]pentyl]benzamide
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C40H38F3N7O6S
 1
1
EC50 = 63.1 nM
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CP0394586
(2S,3S,4R,5R)-5-[6-[6-[[4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]benzoyl]amino]hexylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
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C43H43F3N8O6S
 1
1
EC50 = 75.86 nM
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CP0389136
N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]-4-[3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]benzamide
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C34H35F3N6O5S
 1
1
EC50 = 91.2 nM
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CP0544796
N-[4-[4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]phenyl]butyl]benzamide
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C27H30N6O5
 1
1
EC50 = 95.5 nM
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CP0417389
4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C41H41F3N8O6S
 1
1
EC50 = 97.72 nM
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CP0451309
4-[[4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]phenyl]methylcarbamoyl]benzenesulfonyl fluoride
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C24H23FN6O7S
 1
1
EC50 = 117.49 nM
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CP0911591
2-Amino-N6-benzyladenosine-5'-N-methylcarboxamide
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C18H21N7O4
 1
1
EC50 = 125.89 nM
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CP0394590
4-[4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C41H39F3N6O6S
 1
1
EC50 = 147.91 nM
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CP0546136
4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[4-[4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]phenyl]but-3-ynyl]benzamide
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C45H36F3N7O6S
 1
1
EC50 = 147.91 nM
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CP0856534
2-Amino-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide
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C18H20IN7O4
 1
1
EC50 = 158.49 nM
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CP0880308
2-Amino-N6-phenethyladenosine-5'-N-methylcarboxamide
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C19H23N7O4
 1
1
EC50 = 158.49 nM
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CP0389138
3-(4-benzoylthiophen-2-yl)-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C34H36N6O6S
 1
1
EC50 = 158.49 nM
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CP0884489
2-Amino-N6-(2,2-diphenylethyl)adenosine-5'-N-methylcarboxamide
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C25H27N7O4
 1
1
EC50 = 199.53 nM
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CP0884491
2-Amino-N6-cyclobutyladenosine-5'-N-methylcarboxamide
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C15H21N7O4
 1
1
EC50 = 199.53 nM
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CP0389165
4-(5-amino-4-benzoylthiophen-2-yl)-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C34H37N7O6S
 1
1
EC50 = 223.87 nM
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CP0451310
1-[[4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]phenyl]methyl]-3-(4-isothiocyanatophenyl)thiourea
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C25H24N8O4S2
 1
1
EC50 = 223.87 nM
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CP0389137
2-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C41H40F3N7O6S
 1
1
EC50 = 288.4 nM
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CP0884485
2-Amino-N6-(3-chlorobenzyl)adenosine-5'-N-methylcarboxamide
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C18H20ClN7O4
 1
1
EC50 = 398.11 nM
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CP0389166
4-[5-amino-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C34H36F3N7O5S
 1
1
EC50 = 446.68 nM
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CP0417388
4-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[7-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]heptyl]benzamide
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C42H42F3N7O6S
 1
1
EC50 = 467.74 nM
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CP0544798
3-[5-amino-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]propanamide
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C37H40F3N7O6S
 1
1
EC50 = 524.81 nM
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CP0478404
4-[5-acetamido-4-benzoyl-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-N-[6-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]hexyl]benzamide
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C43H42F3N7O7S
 1
1
EC50 = 616.6 nM
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CP0444859
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[4-(isothiocyanatomethyl)anilino]purin-9-yl]oxolane-3,4-diol
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C18H18N6O4S
 1
1
EC50 = 707.95 nM
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CP0882253
2-Amino-N6-cyclopentyladenosine-5'-N-methylcarboxamide
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C16H23N7O4
 1
1
EC50 = 794.33 nM
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CP0880307
2-Amino-N6-butyladenosine-5'-N-methylcarboxamide
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C15H23N7O4
 1
1
EC50 = 1258.93 nM
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CP0851044
2-Amino-N6-methyladenosine-5'-N-methylcarboxamide
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C12H17N7O4
 1
1
EC50 = 1584.89 nM
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CP0856533
2-Amino-N6-ethyladenosine-5'-N-methylcarboxamide
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C13H19N7O4
 1
1
EC50 = 1584.89 nM
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CP0856535
2-Amino-N6-cyclohexyladenosine-5'-N-methylcarboxamide
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C17H25N7O4
 1
1
EC50 = 2511.89 nM
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CP0882232
2-Amino-N6-propyladenosine-5'-N-methylcarboxamide
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C14H21N7O4
 1
1
EC50 = 5011.87 nM
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CP0851043
2-Methylamino-N6-cyclopentyladenosine-5'-N-methylcarboxamide
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C17H25N7O4
 1
1
EC50 > 10000 nM
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CP0856532
2-Diethylamino-N6-cyclopentyladenosine-5'-N-methylcarboxamide
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C20H31N7O4
 1
1
EC50 > 10000 nM
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CP0856536
2-Dimethylamino-N6-cyclopentyladenosine-5'-N-methylcarboxamide
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C18H27N7O4
 1
1
EC50 > 10000 nM
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CP0880309
2-Ethylamino-N6-cyclopentyladenosine-5'-N-methylcarboxamide
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C18H27N7O4
 1
1
EC50 > 10000 nM
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