Brief Information of the Cell Line and Protein
Cell Line ID: CL000308 , T-REx-CHO
Synonyms
T-REX-CHO
T-REx CHO
T-REx-CHO-K1
CHO-T-Rex
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_D586
Protein ID: PT06515 , Nuclear receptor ROR-beta
Gene Name RORB
Organism Rattus norvegicus, Rat
Protein Classification Unclassified protein
Uniprot ID P45446
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000308  Protein ID: PT06515
 
Compound ID Compound Name Compound Formula
CP0546761
(4S)-4-benzyl-1-[4-[(5S)-2-(cyclohexylmethyl)-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thione
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C32H44N4S
 1
1
IC50 = 8300 nM
   TI
   LI
   LO
   TS
CP0477696
(4S)-4-benzyl-1-[4-[(5S)-2-[(3-methoxyphenyl)methyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thione
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C33H40N4OS
 1
1
IC50 = 8400 nM
   TI
   LI
   LO
   TS
CP0437053
(4S)-4-benzyl-1-[4-[(5S)-2-[(3-methylphenyl)methyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thione
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C33H40N4S
 1
1
IC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0558949
(4S)-4-benzyl-1-[4-[(5S)-2-(2-cyclopentylethyl)-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thione
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C32H44N4S
 1
1
IC50 = 9100 nM
   TI
   LI
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CP0477695
(4S)-4-benzyl-3-(3-cyclopentylpropyl)-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C28H44N4S
 1
1
IC50 = 10200 nM
   TI
   LI
   LO
   TS
CP0517818
(4S)-3-[2-(2-adamantyl)ethyl]-4-benzyl-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C32H48N4S
 1
1
IC50 = 10700 nM
   TI
   LI
   LO
   TS
CP0521097
(4S)-4-benzyl-3-(2-phenylethyl)-1-[4-[(5S)-2-(2-phenylpropyl)-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C34H42N4S
 1
1
IC50 = 10900 nM
   TI
   LI
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   TS
CP0393577
(4S)-4-benzyl-1-[4-[(5S)-2-[(3-fluorophenyl)methyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thione
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C32H37FN4S
 1
1
IC50 = 12400 nM
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   TS
CP0437049
(4S)-4-benzyl-1-[4-[(5S)-2-[(4-fluorophenyl)methyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thione
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C32H37FN4S
 1
1
IC50 = 12400 nM
   TI
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   TS
CP0393578
(4S)-4-benzyl-3-(2-phenylethyl)-1-[4-[(5S)-2-[(E)-prop-1-enyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C28H36N4S
 1
1
IC50 = 12500 nM
   TI
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   TS
CP0534792
(4S)-4-benzyl-3-(2-phenylethyl)-1-[4-[(5S)-2-prop-2-enyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C28H36N4S
 1
1
IC50 = 14300 nM
   TI
   LI
   LO
   TS
CP0437050
(4S)-4-benzyl-3-[2-(2-bicyclo[2.2.1]heptanyl)ethyl]-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C29H44N4S
 1
1
IC50 = 17000 nM
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CP0393576
(4S)-4-butyl-3-(2-phenylethyl)-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C25H40N4S
 1
1
IC50 = 17500 nM
   TI
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CP0393579
(4S)-4-benzyl-3-[(4-methylcyclohexyl)methyl]-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C28H44N4S
 1
1
IC50 = 21100 nM
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CP0477697
(4R)-4-tert-butyl-3-(2-phenylethyl)-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thione
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C25H40N4S
 1
1
IC50 = 22300 nM
   TI
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