Brief Information of the Cell Line and Protein
Cell Line ID: CL000298 , H4-II-E
Synonyms
H-4-II-E
H4IIE
Category Cancer cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_0284
Protein ID: PT03261 , Peroxisome proliferator-activated receptor alpha
Gene Name PPARA
Organism Rattus norvegicus, Rat
Protein Classification Transcription factor
Uniprot ID P37230
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000298  Protein ID: PT03261
 
Compound ID Compound Name Compound Formula
CP0454151
(R)-2-(2-(1-ethyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
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C23H25F3N2O4S
 1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CP0546287
2-(2-(1-ethyl-3-(4-(trifluoromethylthio)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C23H25F3N2O3S2
 1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
CP0528057
2-(2-(1-ethyl-3-(4-isopropylphenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
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C25H32N2O3S
 1
1
EC50 = 32 nM
   TI
   LI
   LO
   TS
CP0457895
2-(2-(1-ethyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C23H25F3N2O4S
 1
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
CP0457894
2-methyl-2-(2-(1-pentyl-3-(4-(trifluoromethylthio)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
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C26H31F3N2O3S2
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0546288
2-methyl-2-(2-(3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C21H21F3N2O4S
 1
1
EC50 = 96 nM
   TI
   LI
   LO
   TS
CP0526614
2-methyl-2-(2-(1-pentyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C26H31F3N2O4S
 1
1
EC50 = 105 nM
   TI
   LI
   LO
   TS
CP0433147
2-(2-(3-(4-(dimethylamino)phenyl)-1-ethylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C24H31N3O3S
 1
1
EC50 = 117 nM
   TI
   LI
   LO
   TS
CP0528056
2-(2-(3-(4-(dimethylamino)phenyl)-1-pentylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
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C27H37N3O3S
 1
1
EC50 = 141 nM
   TI
   LI
   LO
   TS
CP0526627
(R)-2-methyl-2-(2-(3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C21H21F3N2O4S
 1
1
EC50 = 146 nM
   TI
   LI
   LO
   TS
CP0454147
2-methyl-2-(2-(1-propyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C24H27F3N2O4S
 1
1
EC50 = 158 nM
   TI
   LI
   LO
   TS
CP0546284
2-(2-(3-(4-isopropylphenyl)-1-pentylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H38N2O3S
 1
1
EC50 = 159 nM
   TI
   LI
   LO
   TS
CP0546286
2-(2-(1-butyl-3-(4-(trifluoromethylthio)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C25H29F3N2O3S2
 1
1
EC50 = 160 nM
   TI
   LI
   LO
   TS
CP0372141
(S)-2-(2-(1-ethyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C23H25F3N2O4S
 1
1
EC50 = 165 nM
   TI
   LI
   LO
   TS
CP0170396
2-{[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)amino}ethyl)phenyl]sulfanyl}-2-methylpropanoic acid
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C26H34F2N2O3S
 1
1
EC50 = 166 nM
   TI
   LI
   LO
   TS
CP0372140
2-(2-(1-hexyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
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C27H33F3N2O4S
 1
1
EC50 = 166 nM
   TI
   LI
   LO
   TS
CP0461629
(R)-2-(2-(1-heptyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
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C28H35F3N2O4S
 1
1
EC50 = 169 nM
   TI
   LI
   LO
   TS
CP0492819
2-(2-(1-hexyl-3-(4-isopropylphenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
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C29H40N2O3S
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0461627
2-(2-(1-butyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
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C25H29F3N2O4S
 1
1
EC50 = 195 nM
   TI
   LI
   LO
   TS
CP0546289
2-(2-(1-heptyl-3-(4-(methylthio)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H38N2O3S2
 1
1
EC50 = 210 nM
   TI
   LI
   LO
   TS
CP0461625
2-(2-(3-(4-(dimethylamino)phenyl)-1-hexylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H39N3O3S
 1
1
EC50 = 219 nM
   TI
   LI
   LO
   TS
CP0526628
2-(2-(1-heptyl-3-(4-(trifluoromethylthio)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H35F3N2O3S2
 1
1
EC50 = 229 nM
   TI
   LI
   LO
   TS
CP0461626
2-(2-(1-hexyl-3-(4-(trifluoromethylthio)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C27H33F3N2O3S2
 1
1
EC50 = 249 nM
   TI
   LI
   LO
   TS
CP0454148
2-(2-(1-heptyl-3-(4-isopropylphenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C30H42N2O3S
 1
1
EC50 = 252 nM
   TI
   LI
   LO
   TS
CP0457898
2-(2-(3-(4-(dimethylamino)phenyl)-1-heptylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C29H41N3O3S
 1
1
EC50 = 252 nM
   TI
   LI
   LO
   TS
CP0433146
2-(2-(1-butyl-3-(4-isopropylphenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C27H36N2O3S
 1
1
EC50 = 260 nM
   TI
   LI
   LO
   TS
CP0461630
2-(2-(1-heptyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H35F3N2O4S
 1
1
EC50 = 294 nM
   TI
   LI
   LO
   TS
CP0454143
2-(2-(1-isopentyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
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C26H31F3N2O4S
 1
1
EC50 = 386 nM
   TI
   LI
   LO
   TS
CP0457892
2-(2-(1-(2-methoxyethyl)-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C24H27F3N2O5S
 1
1
EC50 = 425 nM
   TI
   LI
   LO
   TS
CP0457605
2-(2-(1-butyl-3-(4-(dimethylamino)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C26H35N3O3S
 1
1
EC50 = 561 nM
   TI
   LI
   LO
   TS
CP0457891
2-(2-(1-ethyl-3-(2-methyl-4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C24H27F3N2O4S
 1
1
EC50 = 598 nM
   TI
   LI
   LO
   TS
CP0528062
2-methyl-2-(2-(1-(4,4,4-trifluorobutyl)-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C25H26F6N2O4S
 1
1
EC50 = 707 nM
   TI
   LI
   LO
   TS
CP0546290
2-(2-(1-heptyl-3-(4-methoxyphenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H38N2O4S
 1
1
EC50 = 910 nM
   TI
   LI
   LO
   TS
CP0461624
2-methyl-2-(2-(1-octyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C29H37F3N2O4S
 1
1
EC50 = 1030 nM
   TI
   LI
   LO
   TS
CP0457896
(S)-2-methyl-2-(2-(3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C21H21F3N2O4S
 1
1
EC50 = 1110 nM
   TI
   LI
   LO
   TS
CP0461631
2-(2-(1-heptyl-3-(3-methoxyphenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H38N2O4S
 1
1
EC50 = 1110 nM
   TI
   LI
   LO
   TS
CP0457899
2-(2-(1-heptyl-3-(4-(trifluoromethyl)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H35F3N2O3S
 1
1
EC50 = 1270 nM
   TI
   LI
   LO
   TS
CP0461633
2-(2-(1-heptyl-3-(2-(trifluoromethylthio)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H35F3N2O3S2
 1
1
EC50 = 1960 nM
   TI
   LI
   LO
   TS
CP0461632
2-(2-(3-(3-chlorophenyl)-1-heptylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C27H35ClN2O3S
 1
1
EC50 = 2090 nM
   TI
   LI
   LO
   TS
CP0457893
2-(2-(1-isobutyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C25H29F3N2O4S
 1
1
EC50 = 2340 nM
   TI
   LI
   LO
   TS
CP0457900
2-(2-(3-(3-fluorophenyl)-1-heptylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C27H35FN2O3S
 1
1
EC50 = 2670 nM
   TI
   LI
   LO
   TS
CP0454150
2-(2-(1-heptyl-3-(3-(trifluoromethyl)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H35F3N2O3S
 1
1
EC50 = 2730 nM
   TI
   LI
   LO
   TS
CP0490400
2-methyl-2-(2-(1-methyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C22H23F3N2O4S
 1
1
EC50 = 2850 nM
   TI
   LI
   LO
   TS
CP0457901
2-(2-(1-heptyl-3-(2-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H35F3N2O4S
 1
1
EC50 = 4990 nM
   TI
   LI
   LO
   TS
CP0372142
2-(2-(1-heptyl-3-(2-(trifluoromethyl)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H35F3N2O3S
 1
1
EC50 = 6390 nM
   TI
   LI
   LO
   TS
CP0504957
2-(2-(1-heptyl-3-o-tolylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H38N2O3S
 1
1
EC50 = 7540 nM
   TI
   LI
   LO
   TS
CP0069869
CIPROFIBRATE
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C13H14Cl2O3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0076778
2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
   Show/Hide
C20H21ClO4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0433144
2-(2-(3-(2,4-difluorophenyl)-1-heptylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C27H34F2N2O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0457902
2-(2-(1-heptyl-3-phenylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C27H36N2O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0461628
2-(2-(1-ethyl-3-methyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C24H27F3N2O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0528058
2-(2-(3-(2-fluorophenyl)-1-heptylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C27H35FN2O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0457897
(S)-2-(2-(1-heptyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C28H35F3N2O4S
 1
1
EC50 > 13000 nM
   TI
   LI
   LO
   TS
CP0433145
2-(2-(3-(2-bromo-4-(trifluoromethoxy)phenyl)-1-ethylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C23H24BrF3N2O4S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0461623
2-(2-(3-(3-bromo-4-(trifluoromethoxy)phenyl)-1-ethylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C23H24BrF3N2O4S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0560080
2-(2-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-ethylureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C23H24ClF3N2O4S
 1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0546282
2-(2-(1-isopropyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid
   Show/Hide
C24H27F3N2O4S
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0546285
2-methyl-2-(2-(3-pentyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid
   Show/Hide
C26H31F3N2O4S
 1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS