General Information of the Compound
Compound ID
CP0069869
Compound Name
CIPROFIBRATE
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Synonyms
2-(4-(2,2-Dichlorocyclopropyl)phenoxy)2-methylpropanoic acid
2-(p-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropionic acid
2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
2-{4-[2,2-dichlorocyclopropyl]phenoxy}-2-methylpropanoic acid
2-{[4-(2,2-dichlorocyclopropyl)phenyl]oxy}-2-methylpropanoic acid
C 0330
Ciprofibrate
Ciprofibrate (USAN/INN)
Ciprofibrate [USAN:BAN:INN]
Ciprofibrato
Ciprofibrato [INN-Spanish]
Ciprofibratum
Ciprofibratum [INN-Latin]
Ciprol
Hiperlipen
Hyperlipen
Lipanor
Modalim
Oroxadin
Sanofi Synthelabo brand of ciprofibrate
Sanofi Winthrop brand of ciprofibrate
WIN 35833
Win 35,833
Win-35833
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Structure
Formula
C13H14Cl2O3
Molecular Weight
289.158
Canonical SMILES
CC(C)(Oc1ccc(cc1)C1CC1(Cl)Cl)C(O)=O
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InChI
InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)
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InChIKey
KPSRODZRAIWAKH-UHFFFAOYSA-N
CAS
52214-84-3
Physicochemical Property
logP
3.5898
Rotatable Bonds
4
Heavy Atom Count
18
Polar Areas
46.53
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 2763
SID: 12013723
ChEMBL ID
CHEMBL557555
DrugBank ID
DB09064
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT03261, Peroxisome proliferator-activated receptor alpha
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000298 H4-II-E
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Ciprofibrate )
Drug Name Ciprofibrate
Indication
Hyperlipoproteinemia
Approved
Target(s)
Peroxisome proliferator-activated receptor alpha (PPARA)
 Target Info 
Agonist