Brief Information of the Cell Line and Protein
Cell Line ID: CL000233 , L1.2
Synonyms
L1-2
Category Cancer cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_9576
Protein ID: PT00903 , C-C chemokine receptor type 5
Gene Name CCR5
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P51681
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000233  Protein ID: PT00903
 
Compound ID Compound Name Compound Formula
CP0398191
(4,6-dimethyl-1-oxy-pyrimidin-5-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C30H37N5O2
 1
1
IC50 = 13.3 nM
   TI
   LI
   LO
   TS
CP0405009
(4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methylpiperidin-1-yl)(2,6-dimethylphenyl)methanone
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C33H41N3O
 1
1
IC50 = 14.4 nM
   TI
   LI
   LO
   TS
CP0405010
(2,6-Dimethyl-phenyl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C32H39N3O
 1
1
IC50 = 14.4 nM
   TI
   LI
   LO
   TS
CP0377973
[4-[4-(N-benzylanilino)piperidin-1-yl]-4-methylpiperidin-1-yl]-(2,4-dimethyl-1-oxidopyridin-1-ium-3-yl)methanone
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C32H40N4O2
 1
1
IC50 = 14.9 nM
   TI
   LI
   LO
   TS
CP0036979
(2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(phenyl-pyridin-3-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone
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C30H37N5O2
 1
1
IC50 = 16.2 nM
   TI
   LI
   LO
   TS
CP0377974
(4,6-Dimethyl-2-phenyl-pyrimidin-5-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C36H41N5O
 1
1
IC50 = 16.5 nM
   TI
   LI
   LO
   TS
CP0448229
(4,6-Dimethyl-2-pyridin-4-yl-pyrimidin-5-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C35H40N6O
 1
1
IC50 = 24.6 nM
   TI
   LI
   LO
   TS