Brief Information of the Cell Line and Protein
Cell Line ID: CL000218 , BT-474
Synonyms
Bt-474
BT474
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0179
Protein ID: PT01233 , Receptor tyrosine-protein kinase erbB-2
Gene Name ERBB2
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P04626
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000218  Protein ID: PT01233
 
Compound ID Compound Name Compound Formula
CP0062381
(6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
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C19H23N3O3
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0145145
(1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
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C25H36N4O4
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0051806
(6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
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C20H25N3O3
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0265483
(2S,3S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)piperidine-3-carboxamide
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C23H33N5O4
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0051802
(6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
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C19H26N4O3
 1
1
IC50 = 52 nM
   TI
   LI
   LO
   TS
CP0069968
(1S,2S,5RS)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
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C25H36N4O4
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0136417
(1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piperidine-1-carbonyl)-5-(2-oxo-2-(piperidin-1-yl)ethyl)cyclohexanecarboxamide
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C29H43N3O4
 1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
CP0035501
(6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate
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C22H27N3O5
 1
1
IC50 = 68 nM
   TI
   LI
   LO
   TS
CP0062383
(6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide
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C19H25N3O3
 1
1
IC50 = 92 nM
   TI
   LI
   LO
   TS
CP0136416
(1S,2S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
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C24H34N4O4
 1
1
IC50 = 99 nM
   TI
   LI
   LO
   TS
CP0069966
(1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
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C25H37N5O4
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0275926
(5S,6S)-N-hydroxy-6-(4-phenylpiperazine-1-carbonyl)spiro[2.5]octane-5-carboxamide
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C20H27N3O3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0145144
(2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(piperidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)piperidine-3-carboxamide
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C25H37N5O4
 1
1
IC50 = 102 nM
   TI
   LI
   LO
   TS
CP0128711
benzyl N-[5-[[2-[(5S,6S)-5-(hydroxycarbamoyl)-6-(3-phenylpyrrolidine-1-carbonyl)piperidin-3-yl]acetyl]amino]pentyl]carbamate
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C32H43N5O6
 1
1
IC50 = 137 nM
   TI
   LI
   LO
   TS
CP0035541
(6S,7S)-6-(4-phenyl-piperidine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
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C20H27N3O3
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0007142
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
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C29H26ClFN4O4S
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0051666
(6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamide
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C21H27N3O3
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0051669
(6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)piperazin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide
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C20H27N5O5
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0094199
(2S,3S,5RS)-5-(2-(5-aminopentylamino)-2-oxoethyl)-N-hydroxy-2-(3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide
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C24H37N5O4
 1
1
IC50 = 162 nM
   TI
   LI
   LO
   TS
CP0280251
(1S,2S,5R)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
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C25H36N4O4
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0136415
(2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)piperidine-3-carboxamide
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C24H35N5O4
 1
1
IC50 = 194 nM
   TI
   LI
   LO
   TS
CP0069967
(1S,2S,5RS)-N-hydroxy-5-(2-morpholino-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
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C24H34N4O5
 1
1
IC50 = 208 nM
   TI
   LI
   LO
   TS
CP0371195
(1S,2S,5RS)-N-hydroxy-5-(2-((R)-3-hydroxypyrrolidin-1-yl)-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
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C24H34N4O5
 1
1
IC50 = 226 nM
   TI
   LI
   LO
   TS
CP0051668
(6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide
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C20H28N4O3
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0051664
(6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino[1,2-a]indol-2(1H)-ylcarbonyl)-5-azaspiro[2.5]octane-7-carboxamide
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C20H26N4O3
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0156646
(6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)-3,6-dihydropyridin-1(2H)-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide
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C21H26N4O5
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0100818
N-[4-[4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-7-chloro-1,3-benzoxazol-2-amine
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C29H32ClN9O
 1
1
IC50 = 340 nM
   TI
   LI
   LO
   TS
CP0035538
(6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
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C19H25N3O3
 1
1
IC50 = 359 nM
   TI
   LI
   LO
   TS
CP0055593
CHEMBL1256432
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C29H31ClFN9O
 1
1
IC50 = 362 nM
   TI
   LI
   LO
   TS
CP0128710
(1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
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C18H25N3O3
 1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0514257
(2S,3S)-N-hydroxy-2-((R)-3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide
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C17H23N3O3
 1
1
IC50 = 560 nM
   TI
   LI
   LO
   TS
CP0052993
1-(4-Methoxy-benzenesulfonyl)-piperidine-2-carboxylic acid hydroxyamide
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C13H18N2O5S
 1
1
IC50 = 670 nM
   TI
   LI
   LO
   TS
CP0062382
(6S,7S)-N-hydroxy-6-[(5-methyl-4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamide
   Show/Hide
C21H27N3O3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0037987
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
   Show/Hide
C22H23N3O4
 1
1
IC50 = 6730 nM
   TI
   LI
   LO
   TS
CP0378284
3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine
   Show/Hide
C30H31N7
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS