1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylimidazol-2-yl)sulfonylpiperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(methylsulfonylmethylsulfonyl)piperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(difluoromethylsulfonyl)piperazine

1-cyclopropylsulfonyl-4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(trifluoromethylsulfonyl)piperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylsulfonylpiperazine

4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)pyridine

ethyl 2-(3-(1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperidin-4-yl)ureido)acetate

2-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]sulfonylacetonitrile

1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(isopropylsulfonyl)piperazine

1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(isopropylsulfonyl)piperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(oxan-4-ylsulfonyl)piperazine

1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(ethylsulfonyl)piperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-thiophen-2-ylsulfonylpiperazine

1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-nitrophenylsulfonyl)piperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(2-methoxyethylsulfonyl)piperazine

1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(3-(trifluoromethoxy)phenylsulfonyl)piperazine

1-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]-4-propan-2-ylsulfonylpiperazine

1-(4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-yl)ethanone

ethyl 2-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazine-1-carboxamido)acetate

1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(cyclopropylsulfonyl)piperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-ethylsulfonylpiperazine

1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(pyridin-3-ylsulfonyl)piperazine

3-((4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)methyl)benzonitrile

1-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]-4-(trifluoromethylsulfonyl)piperazine

1-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-cyclopropylsulfonylpiperazine

4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)pyridine

1-cyclopropylsulfonyl-4-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazine

3-(4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-ylsulfonyl)benzonitrile

US9725436, Entry 7

1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(1H-imidazol-4-ylsulfonyl)piperazine

1-[4-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazin-1-yl]ethanone

4-(3-fluoro-5-(4-(pyridin-4-yl)phenethyl)phenyl)pyridine

1-ethylsulfonyl-4-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazine

1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-(trifluoromethoxy)phenylsulfonyl)piperazine

1-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-ethylsulfonylpiperazine

US9725436, Entry 8

2-methoxyethyl 4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazine-1-carboxylate

1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(cyclopropylmethyl)piperazine

US9725436, Entry 12

US9725436, Entry 3

1-(cyclopropylmethyl)-4-(4-(3-fluoro-5-(pyridin-4-yl)styryl)phenyl)piperazine

4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-N,N-dimethylpiperazine-1-carboxamide

2-methoxyethyl 4-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazine-1-carboxylate

US9725436, Entry 4

4-(3-fluoro-5-(4-(pyridin-4-yl)styryl)phenyl)pyridine

4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)morpholine

US9725436, Entry 15

1-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)-4-(isopropylsulfonyl)piperazine

ethyl 2-(4-(4-(3-fluoro-5-(pyridin-4-yl)styryl)phenyl)piperazine-1-carboxamido)acetate

1-[4-[4-[(E)-2-(3-chloro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazin-1-yl]ethanone

1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(3-chloropropylsulfonyl)piperazine

US9725436, Entry 6

US9725436, Entry 10

1-(cyclopropylsulfonyl)-4-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)piperazine

3-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-ylsulfonyl)benzonitrile

1-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-pyridin-3-ylsulfonylpiperazine

(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)(cyclopropyl)methanone

1-(4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-yl)ethanone

1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(methylsulfonyl)piperazine

1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-methylsulfonylpiperazine

1-(ethylsulfonyl)-4-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)piperazine

1-(4-(4-(3-hydroxy-5-(1H-imidazol-1-yl)styryl)phenyl)piperazin-1-yl)ethanone

US9725436, Entry 2

1-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-hydroxystyryl)phenyl)piperazin-1-yl)ethanone

1-(4-(4-(3-chloro-5-(2-methyl-1-(pyridin-3-yl)prop-1-enyl)styryl)phenyl)piperazin-1-yl)ethanone

1-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(methylsulfonyl)piperazine

4-(3-(4-bromostyryl)-5-fluorophenyl)pyridine

1-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)-4-(trifluoromethylsulfonyl)piperazine

ethyl 2-(4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazine-1-carboxamido)acetate

1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-chloropropylsulfonyl)piperazine

1-(4-(4-(3-chloro-5-(1-hydroxy-2-methyl-1-(pyridin-3-yl)propyl)styryl)phenyl)piperazin-1-yl)ethanone

1-(4-(3-fluoro-5-(pyridin-4-yl)styryl)phenyl)-4-(pyridin-3-ylsulfonyl)piperazine

US9725436, Entry 17

US8987315, Ketoconazole

4-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)morpholine

US9725436, Entry 5

US9725436, Entry 13

US9725436, Entry 14

2-[4-[4-[(E)-2-[3-fluoro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazin-1-yl]sulfonylacetonitrile

US9725436, Entry 1

US9725436, Entry 11

1-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-(1H-imidazol-5-ylsulfonyl)piperazine

US9725436, Entry 9

1-(4-(4-(3-chloro-5-(pyridin-3-yl)styryl)phenyl)piperazin-1-yl)ethanone

1-(4-(4-(3-chloro-5-(pyridin-3-ylmethyl)styryl)phenyl)piperazin-1-yl)ethanone

(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)(pyridin-3-yl)methanone

ethyl 2-(4-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)piperazine-1-carboxamido)acetate

1-(4-(4-(3-chloro-5-((pyridin-3-yloxy)methyl)styryl)phenyl)piperazin-1-yl)ethanone

3-(4-bromostyryl)-5-(1H-imidazol-1-yl)phenol

3-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazine-1-carbonyl)benzonitrile

1-(4-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)piperazin-1-yl)ethanone

1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(4-chloro-3-nitrophenylsulfonyl)piperazine

1-(4-(4-(3-fluoro-5-(pyridin-3-yl)styryl)phenyl)piperazin-1-yl)ethanone

(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)(3-nitrophenyl)methanone

ethyl 2-(4-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazine-1-carboxamido)acetate

1-(4-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-yl)ethanone

1-(4-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-yl)ethanone