Brief Information of the Cell Line and Protein
Cell Line ID: CL000162 , HeLa S3
 Cell Line Info 
Synonyms
HeLa s3
HeLa-S3
HELA-S3
HeLa/S3
HeLa.S3
HeLa S 3
HeLa S-3
HeLaS3
HeLa, S3 clone
S3-HeLa
S3 HeLa
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0058
Protein ID: PT00865 , Serine/threonine-protein kinase Chk1
 Protein Info 
Gene Name CHEK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID O14757
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000162
 Cell Line Info 
 Protein ID: PT00865
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0703621
 Compound Info 
(R)-4-(6-(1H-indol-4-yl)-1-(methylsulfonylmethyl)-1H-imidazo[4,5-c]pyridin-4-yl)-3-methylmorpholine
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C21H23N5O3S
  1
1
EC50 = 570 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0347294
 Compound Info 
4-[6-(1H-indol-4-yl)-1-(methylsulfonylmethyl)imidazo[4,5-c]pyridin-4-yl]morpholine
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C20H21N5O3S
  1
1
EC50 = 3300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0761978
 Compound Info 
(R)-5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-6-methyl-3-(1-(methylsulfonyl)piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine
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C20H25ClN6O2S
  1
1
IC50 = 37 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0257870
 Compound Info 
N,N-dimethyl-4-[6-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-3-yl]benzenesulfonamide
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C21H18N6O2S
  1
1
IC50 = 44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701864
 Compound Info 
(R)-6-methyl-3-(4-(methylsulfonyl)phenyl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine
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C21H21N5O2S
  1
1
IC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701867
 Compound Info 
(R)-3-methyl-4-(1-((R)-1-(methylsulfonyl)ethyl)-6-(1H-pyrrolo[2,3-c]pyridin-4-yl)-1H-imidazo[4,5-c]pyridin-4-yl)morpholine
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C21H24N6O3S
  1
1
IC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0795849
 Compound Info 
(R)-3-methyl-4-(1-methyl-6-(1H-pyrrolo[2,3-c]pyridin-4-yl)-1H-imidazo[4,5-c]pyridin-4-yl)morpholine
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C19H20N6O
  1
1
IC50 = 84 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0761979
 Compound Info 
(R)-4-(6-(5-fluoro-1H-pyrrolo[2,3-c]pyridin-4-yl)-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl)-3-methylmorpholine
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C19H19FN6O
  1
1
IC50 = 96 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0870828
 Compound Info 
(R)-N,N-dimethyl-4-(6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)benzenesulfonamide
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C22H24N6O2S
  1
1
IC50 = 123 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0772154
 Compound Info 
(R)-6-methyl-3-(1-(methylsulfonyl)piperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine
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C20H26N6O2S
  1
1
IC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0247185
 Compound Info 
N,N-dimethyl-4-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide
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C21H22N6O2S
  1
1
IC50 = 327 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS