Brief Information of the Cell Line and Protein
Cell Line ID: CL000145 , NCI-H460
Synonyms
NCI.H460
H460
H-460
NCIH460
NCI-HUT-460
NCI-460
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0459
Protein ID: PT00922 , Epidermal growth factor receptor
Gene Name EGFR
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P00533
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000145  Protein ID: PT00922
 
Compound ID Compound Name Compound Formula
CP0408607
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
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C24H27ClN6O4
 1
1
IC50 = 2010 nM
   TI
   LI
   LO
   TS
CP0408596
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
   Show/Hide
C25H29ClN6O4
 1
1
IC50 = 2150 nM
   TI
   LI
   LO
   TS
CP0482007
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
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C25H27ClN6O3
 1
1
IC50 = 2480 nM
   TI
   LI
   LO
   TS
CP0905681
N-(2-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)-3-benzyloxypropanamide
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C32H35ClN6O4
 1
1
IC50 = 3060 nM
   TI
   LI
   LO
   TS
CP0905680
N-(2-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)-2-benzyloxyacetamide
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C31H33ClN6O4
 1
1
IC50 = 3530 nM
   TI
   LI
   LO
   TS
CP0471792
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
   Show/Hide
C24H27ClN6O4
 1
1
IC50 = 3870 nM
   TI
   LI
   LO
   TS
CP0408613
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-phenylmethoxyacetamide
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C31H33ClN6O4
 1
1
IC50 = 4790 nM
   TI
   LI
   LO
   TS
CP0472905
(E)-N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
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C28H34ClN7O3
 1
1
IC50 = 5020 nM
   TI
   LI
   LO
   TS
CP0408652
4-(3-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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C22H23ClN8O2
 1
1
IC50 = 6020 nM
   TI
   LI
   LO
   TS
CP0478346
4-(2-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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C22H23ClN8O2
 1
1
IC50 = 6340 nM
   TI
   LI
   LO
   TS
CP0518127
4-(3-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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C22H25ClN6O2
 1
1
IC50 = 6680 nM
   TI
   LI
   LO
   TS
CP0408595
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
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C25H27ClN6O3
 1
1
IC50 = 6980 nM
   TI
   LI
   LO
   TS
CP0534556
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
   Show/Hide
C24H27ClN6O3
 1
1
IC50 = 8550 nM
   TI
   LI
   LO
   TS
CP0408609
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-phenylmethoxyacetamide
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C31H33ClN6O4
 1
1
IC50 = 9500 nM
   TI
   LI
   LO
   TS
CP0429398
4-(2-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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C22H25ClN6O2
 1
1
IC50 = 9780 nM
   TI
   LI
   LO
   TS
CP0511869
(E)-N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
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C28H34ClN7O3
 1
1
IC50 = 10020 nM
   TI
   LI
   LO
   TS
CP0432728
(E)-N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
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C28H34ClN7O3
 1
1
IC50 = 12020 nM
   TI
   LI
   LO
   TS
CP0432757
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(4-nitrophenoxy)pyrimidin-2-amine
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C22H23ClN6O4
 1
1
IC50 = 12030 nM
   TI
   LI
   LO
   TS
CP0482008
4-(4-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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C22H25ClN6O2
 1
1
IC50 = 14010 nM
   TI
   LI
   LO
   TS
CP0494495
5-chloro-4-(4-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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C23H23ClN6O2S
 1
1
IC50 = 15270 nM
   TI
   LI
   LO
   TS
CP0408606
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
   Show/Hide
C24H27ClN6O4
 1
1
IC50 = 15830 nM
   TI
   LI
   LO
   TS
CP0429397
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-phenylmethoxypropanamide
   Show/Hide
C32H35ClN6O4
 1
1
IC50 = 16970 nM
   TI
   LI
   LO
   TS
CP0408612
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
   Show/Hide
C24H27ClN6O3
 1
1
IC50 = 17410 nM
   TI
   LI
   LO
   TS
CP0472903
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-phenylmethoxypropanamide
   Show/Hide
C32H35ClN6O4
 1
1
IC50 = 17930 nM
   TI
   LI
   LO
   TS
CP0059062
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
   Show/Hide
C25H27ClN6O3
 1
1
IC50 = 18210 nM
   TI
   LI
   LO
   TS
CP0472904
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
   Show/Hide
C25H29ClN6O4
 1
1
IC50 = 18300 nM
   TI
   LI
   LO
   TS
CP0478344
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(2-nitrophenoxy)pyrimidin-2-amine
   Show/Hide
C22H23ClN6O4
 1
1
IC50 = 19630 nM
   TI
   LI
   LO
   TS
CP0482004
5-chloro-4-(2-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
   Show/Hide
C23H23ClN6O2S
 1
1
IC50 = 20120 nM
   TI
   LI
   LO
   TS
CP0408650
5-chloro-4-(3-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
   Show/Hide
C23H23ClN6O2S
 1
1
IC50 = 22330 nM
   TI
   LI
   LO
   TS
CP0036082
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
   Show/Hide
C22H24ClFN4O3
 1
1
IC50 = 22800 nM
   TI
   LI
   LO
   TS
CP0408610
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
   Show/Hide
C25H29ClN6O4
 1
1
IC50 = 23310 nM
   TI
   LI
   LO
   TS
CP0432729
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(3-nitrophenoxy)pyrimidin-2-amine
   Show/Hide
C22H23ClN6O4
 1
1
IC50 = 23570 nM
   TI
   LI
   LO
   TS
CP0482006
4-(4-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
   Show/Hide
C22H23ClN8O2
 1
1
IC50 = 26870 nM
   TI
   LI
   LO
   TS
CP0408611
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
   Show/Hide
C24H27ClN6O3
 1
1
IC50 = 33210 nM
   TI
   LI
   LO
   TS