Brief Information of the Cell Line and Protein
Cell Line ID: CL000118 , U-251MG
Synonyms
U-251 MG
U-251-MG
U-251_MG
U251-MG
U251MG
U-251
U251
U251n
U251N
251 MG
251MG
251 MG(6)
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0021
Protein ID: PT00839 , Poly [ADP-ribose] polymerase 1
Gene Name PARP1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P09874
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000118  Protein ID: PT00839
 
Compound ID Compound Name Compound Formula
CP0477884
8-(2-bromo-acetyl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C19H13BrN2O3
 1
1
IC50 = 13 nM
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CP0445412
8-{2-[((3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-methyl]-thiazol-4-yl}-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C27H26N4O7S
 1
1
IC50 = 17 nM
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CP0477885
8-acetyl-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C19H14N2O3
 1
1
IC50 = 17 nM
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CP0474505
10-(aminomethyl)-4,5,6,7-tetrahydro-1Hcyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione
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C18H15N3O2
 1
1
IC50 = 18 nM
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CP0477881
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]methanesulfonamide
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C22H18N4O4S2
 1
1
IC50 = 18 nM
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CP0464198
2-[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]guanidine
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C21H16N6O2S
 1
1
IC50 = 19 nM
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CP0467806
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]acetamide
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C23H18N4O3S
 1
1
IC50 = 20 nM
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CP0503870
1-[4-(4,6-dioxo-2,3,4,5,6,11-hexahydro-1H-5,11-diaza-benzo[a]trinden-8-yl)-thiazol-2-ylmethyl]-3-ethyl-urea
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C24H21N5O3S
 1
1
IC50 = 20 nM
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CP0553855
benzyl N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]carbamate
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C29H22N4O4S
 1
1
IC50 = 20 nM
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CP0426906
8-[2-(2-methyl-propane-2-sulfonylmethyl)-thiazol-4-yl]-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C25H23N3O4S2
 1
1
IC50 = 21 nM
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CP0862800
2-amino-5-[4-(4,6-dioxo-2,3,4,5,6,11-hexahydro-1H-5,11-diaza-benzo[a]trinden-8-yl)-thiazol-2-yl]-pentanoic acid trifluoro-acetic acid salt
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C27H23F3N4O6S
 1
1
IC50 = 22 nM
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CP0526569
8-(2-amino-thiazol-4-yl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C20H14N4O2S
 1
1
IC50 = 25 nM
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CP0477880
tert-butyl 2-[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]acetate
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C26H23N3O4S
 1
1
IC50 = 29 nM
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CP0467805
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]-2-methylpropanamide
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C25H22N4O3S
 1
1
IC50 = 32 nM
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CP0059801
1,2,3,11-Tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C17H12N2O2
 1
1
IC50 = 36 nM
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CP0542203
8-(2-methanesulfonylmethyl-thiazol-4-yl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C22H17N3O4S2
 1
1
IC50 = 38 nM
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CP0477883
8-(2-methyl-thiazol-4-yl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C21H15N3O2S
 1
1
IC50 = 40 nM
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CP0445413
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]butanamide
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C25H22N4O3S
 1
1
IC50 = 42 nM
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CP0862801
8-(2-aminomethyl-thiazol-4-yl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione hydrobromide
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C21H17BrN4O2S
 1
1
IC50 = 42 nM
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CP0426907
2-tert-butoxycarbonylamino-5-[4-(4,6-dioxo-2,3,4,5,6,11-hexahydro-1H-5,11-diaza-benzo[a]trinden-8-yl)-thiazol-2-yl]-pentanoic acid tert-butyl ester
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C34H38N4O6S
 1
1
IC50 = 46 nM
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CP0464200
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]cyclopropanecarboxamide
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C25H20N4O3S
 1
1
IC50 = 49 nM
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CP0542204
8-(2-amino-5-methyl-thiazol-4-yl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C21H16N4O2S
 1
1
IC50 = 50 nM
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CP0533064
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]cyclopentanecarboxamide
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C27H24N4O3S
 1
1
IC50 = 52 nM
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CP0464199
8-(2-methylamino-thiazol-4-yl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]rindene-4,6-dione
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C21H16N4O2S
 1
1
IC50 = 54 nM
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CP0535420
N-[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]acetamide
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C22H16N4O3S
 1
1
IC50 = 54 nM
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CP0464201
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]-3-methylbutanamide
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C26H24N4O3S
 1
1
IC50 = 56 nM
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CP0464202
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]propanamide
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C24H20N4O3S
 1
1
IC50 = 56 nM
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CP0525022
N-[[4-(8,10-dioxo-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaen-15-yl)-1,3-thiazol-2-yl]methyl]pentanamide
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C26H24N4O3S
 1
1
IC50 = 56 nM
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CP0462550
2,2-dimethyl-propionic acid 4-(4,6-dioxo-2,3,4,5,6,11-hexahydro-1H-5,11-diaza-benzo[a]trinden-8-yl)-thiazol-2-ylmethyl ester
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C26H23N3O4S
 1
1
IC50 = 60 nM
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CP0426905
8-(2-isoxazol-5-yl-thiazol-4-yl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[]trindene-4,6-dione
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C23H14N4O3S
 1
1
IC50 = 66 nM
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CP0477882
8-(5-bromo-2-methyl-thiazol-4-yl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
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C21H14BrN3O2S
 1
1
IC50 = 84 nM
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