| Compound ID |
Compound Name |
Compound Formula |
|
CP0553736
|
4-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)amino)methyl)-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C29H30F3N3S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0459755
|
4-((bis(cyclohexylmethyl)amino)methyl)-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C28H37N3S
|
3
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
| 3 |
IC50 = 530 nM
|
|
|
|
CP0437489
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)piperidin-3-yl]azetidin-1-yl]pyrazolo[3,4-b]pyrazine-3-carboxamide
Show/Hide
|
C24H29Cl2N7O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0445923
|
4-tert-butyl-N-(1-methylindol-4-yl)-1,3-thiazol-2-amine
Show/Hide
|
C16H19N3S
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0538569
|
N-[2-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]ethyl]acetamide
Show/Hide
|
C26H33Cl2N7O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0491755
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-5-methyl-4-[(2R)-2-methylpyrrolidin-1-yl]cyclohexen-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile
Show/Hide
|
C26H28Cl2N6
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0511218
|
4-((diisobutylamino)methyl)-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C22H29N3S
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0122114
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)piperidin-3-yl]azetidin-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile
Show/Hide
|
C24H27Cl2N7O
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 64 nM
|
|
|
|
CP0222966
|
1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3R,4S)-4-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile hydrochloride
Show/Hide
|
C25H29Cl2N7O
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0560231
|
N-[2-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]ethyl]-2-methylpropanamide
Show/Hide
|
C28H37Cl2N7O
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0119020
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile
Show/Hide
|
C26H28Cl2N6O
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0421519
|
2-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]ethanol
Show/Hide
|
C24H30Cl2N6O
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0525162
|
4-tert-butyl-N-(naphthalen-1-yl)oxazol-2-amine
Show/Hide
|
C17H18N2O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0529792
|
4-tert-butyl-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C17H18N2S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0870714
|
6-(3-((R)-1-((1H-Imidazol-5-yl)methyl)piperidin-3-yl)-azetidin-1-yl)-1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile
Show/Hide
|
C26H27Cl2N9
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0517429
|
3-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]propan-1-ol
Show/Hide
|
C25H32Cl2N6O
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0568680
|
N-[2-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]ethyl]propane-2-sulfonamide
Show/Hide
|
C27H37Cl2N7O2S
|
1
|
| 1 |
IC50 = 115 nM
|
|
|
|
CP0554121
|
methyl N-[2-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]ethyl]carbamate
Show/Hide
|
C26H33Cl2N7O2
|
1
|
| 1 |
IC50 = 133 nM
|
|
|
|
CP0420522
|
N-[2-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]ethyl]methanesulfonamide
Show/Hide
|
C25H33Cl2N7O2S
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0518454
|
((S)-1-((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3-methylpiperidin-4-yl)pyrrolidin-2-yl)methanol hydrochloride
Show/Hide
|
C25H32Cl2N6O
|
1
|
| 1 |
IC50 = 151 nM
|
|
|
|
CP0486939
|
4-isopropyl-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C16H16N2S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0479482
|
[(2S)-1-[(1S,6R)-4-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]-6-methylcyclohex-3-en-1-yl]pyrrolidin-2-yl]methanol
Show/Hide
|
C26H31Cl2N5O
|
1
|
| 1 |
IC50 = 179 nM
|
|
|
|
CP0491478
|
6-((3R,4S)-4-(Azepan-1-yl)-3-methylpiperidin-1-yl)-1-((R)-1-(2,4-dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazine hydrochloride
Show/Hide
|
C26H34Cl2N6
|
1
|
| 1 |
IC50 = 195 nM
|
|
|
|
CP0381608
|
4-tert-butyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C17H22N2S
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0445922
|
4-tert-butyl-N-(1-ethylindol-4-yl)-1,3-thiazol-2-amine
Show/Hide
|
C17H21N3S
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0413069
|
6-((3R,4S)-4-(Azetidin-1-yl)-3-methylpiperidin-1-yl)-1-((R)-1-(2,4-dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazine hydrochloride
Show/Hide
|
C23H28Cl2N6
|
1
|
| 1 |
IC50 = 218 nM
|
|
|
|
CP0538458
|
4-(2,2-dimethylpropyl)-N-naphthalen-1-yl-1,3-thiazol-2-amine
Show/Hide
|
C18H20N2S
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0387502
|
3-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]propanamide
Show/Hide
|
C25H31Cl2N7O
|
1
|
| 1 |
IC50 = 247 nM
|
|
|
|
CP0435249
|
2-[(2S)-1-[(3R,4S)-1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]-3-methylpiperidin-4-yl]pyrrolidin-2-yl]ethanesulfonamide
Show/Hide
|
C26H35Cl2N7O2S
|
1
|
| 1 |
IC50 = 259 nM
|
|
|
|
CP0560230
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methyl-6-[3-[(3R)-1-(3-methylsulfonylpropyl)piperidin-3-yl]azetidin-1-yl]pyrazolo[3,4-b]pyrazine
Show/Hide
|
C26H34Cl2N6O2S
|
1
|
| 1 |
IC50 = 259 nM
|
|
|
|
CP0456503
|
4-tert-butyl-N-(2,3-dimethylphenyl)thiazol-2-amine
Show/Hide
|
C15H20N2S
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0511217
|
4-tert-butyl-N-quinolin-5-yl-1,3-thiazol-2-amine
Show/Hide
|
C16H17N3S
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0445920
|
6-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)amino)methyl)-N-(2,3-dimethylphenyl)pyridin-2-amine
Show/Hide
|
C29H34F3N3
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0536685
|
3-[(2S)-1-[(3R,4S)-1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]-3-methylpiperidin-4-yl]pyrrolidin-2-yl]propanamide
Show/Hide
|
C27H35Cl2N7O
|
1
|
| 1 |
IC50 = 355 nM
|
|
|
|
CP0491477
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methyl-6-[(3R,4S)-3-methyl-4-piperidin-1-ylpiperidin-1-yl]pyrazolo[3,4-b]pyrazine
Show/Hide
|
C25H32Cl2N6
|
1
|
| 1 |
IC50 = 361 nM
|
|
|
|
CP0436953
|
3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)amino)methyl)-N-(2,3-dimethylphenyl)-1-methyl-1H-pyrazol-5-amine
Show/Hide
|
C28H35F3N4
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0525460
|
3-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]propanoic acid
Show/Hide
|
C25H30Cl2N6O2
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0421522
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)piperidin-3-yl]azetidin-1-yl]-N,N-dimethylpyrazolo[3,4-b]pyrazine-3-carboxamide
Show/Hide
|
C26H33Cl2N7O2
|
1
|
| 1 |
IC50 = 379 nM
|
|
|
|
CP0491479
|
1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-6-((3R,4S)-3-methyl-4-((R)-2-methylpyrrolidin-1-yl)piperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine hydrochloride
Show/Hide
|
C25H32Cl2N6
|
1
|
| 1 |
IC50 = 381 nM
|
|
|
|
CP0516861
|
3-[(3R)-3-[1-[3-cyano-1-[(1R)-1-(2,4-dichlorophenyl)ethyl]pyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]propanoic acid
Show/Hide
|
C25H27Cl2N7O2
|
1
|
| 1 |
IC50 = 409 nM
|
|
|
|
CP0486937
|
4-tert-butyl-N-(2-isopropylphenyl)thiazol-2-amine
Show/Hide
|
C16H22N2S
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0516862
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)piperidin-3-yl]azetidin-1-yl]-N-methylpyrazolo[3,4-b]pyrazine-3-carboxamide
Show/Hide
|
C25H31Cl2N7O2
|
1
|
| 1 |
IC50 = 446 nM
|
|
|
|
CP0509464
|
4-tert-butyl-N-(1H-indol-4-yl)-1,3-thiazol-2-amine
Show/Hide
|
C15H17N3S
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0527114
|
6-[3-[(3R)-1-(2-cyanoethyl)piperidin-3-yl]azetidin-1-yl]-1-[(1R)-1-(2,4-dichlorophenyl)ethyl]pyrazolo[3,4-b]pyrazine-3-carbonitrile
Show/Hide
|
C25H26Cl2N8
|
1
|
| 1 |
IC50 = 523 nM
|
|
|
|
CP0517430
|
4-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]butanoic acid
Show/Hide
|
C26H32Cl2N6O2
|
1
|
| 1 |
IC50 = 559 nM
|
|
|
|
CP0387501
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methyl-6-[3-[(3R)-1-(2-methylsulfonylethyl)piperidin-3-yl]azetidin-1-yl]pyrazolo[3,4-b]pyrazine
Show/Hide
|
C25H32Cl2N6O2S
|
1
|
| 1 |
IC50 = 575 nM
|
|
|
|
CP0435250
|
6-[(4S,5R)-4-[(2S)-2-(aminomethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]-1-[(1R)-1-(2,4-dichlorophenyl)ethyl]pyrazolo[3,4-b]pyrazine-3-carbonitrile
Show/Hide
|
C26H29Cl2N7
|
1
|
| 1 |
IC50 = 638 nM
|
|
|
|
CP0387504
|
2-[(3R)-3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]ethanesulfonamide
Show/Hide
|
C24H31Cl2N7O2S
|
1
|
| 1 |
IC50 = 717 nM
|
|
|
|
CP0527112
|
2-[(3R)-3-[1-[3-cyano-1-[(1R)-1-(2,4-dichlorophenyl)ethyl]pyrazolo[3,4-b]pyrazin-6-yl]azetidin-3-yl]piperidin-1-yl]acetic acid
Show/Hide
|
C24H25Cl2N7O2
|
1
|
| 1 |
IC50 = 775 nM
|
|
|
|
CP0486938
|
4-((diethylamino)methyl)-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C18H21N3S
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
|
CP0469426
|
3-[(2S)-1-[(3R,4S)-1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-methylpyrazolo[3,4-b]pyrazin-6-yl]-3-methylpiperidin-4-yl]pyrrolidin-2-yl]propanenitrile
Show/Hide
|
C27H33Cl2N7
|
1
|
| 1 |
IC50 = 865 nM
|
|
|
|
CP0381610
|
4-tert-butyl-N-o-tolylthiazol-2-amine
Show/Hide
|
C14H18N2S
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0381612
|
4-(4-tert-butylphenyl)-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C23H22N2S
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0381611
|
4-((ethylamino)methyl)-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C16H17N3S
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0469427
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile
Show/Hide
|
C28H32Cl2N6O
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0467867
|
(2S)-1-[(1S,6R)-4-[3-cyano-1-[(1R)-1-(2,4-dichlorophenyl)ethyl]pyrazolo[3,4-b]pyrazin-6-yl]-6-methylcyclohex-3-en-1-yl]pyrrolidine-2-carboxamide
Show/Hide
|
C26H27Cl2N7O
|
1
|
| 1 |
IC50 = 1380 nM
|
|
|
|
CP0381606
|
4-tert-butyl-N-isoquinolin-5-yl-1,3-thiazol-2-amine
Show/Hide
|
C16H17N3S
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0538568
|
1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(3,3,3-trifluoropropyl)piperidin-3-yl]azetidin-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile
Show/Hide
|
C25H26Cl2F3N7
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0453249
|
4-methyl-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C14H12N2S
|
3
|
| 1 |
IC50 = 1700 nM
|
|
|
| 2 |
IC50 = 3000 nM
|
|
|
| 3 |
IC50 = 6400 nM
|
|
|
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CP0381609
|
4-tert-butyl-N-m-tolylthiazol-2-amine
Show/Hide
|
C14H18N2S
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0509465
|
4-tert-butyl-N-phenylthiazol-2-amine
Show/Hide
|
C13H16N2S
|
1
|
| 1 |
IC50 = 4500 nM
|
|
|
|
CP0432818
|
N-naphthalen-1-yl-4-phenyl-1,3-thiazol-2-amine
Show/Hide
|
C19H14N2S
|
1
|
| 1 |
IC50 = 5500 nM
|
|
|
|
CP0528583
|
3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)amino)methyl)-N-(2,3-dimethylphenyl)isoxazol-5-amine
Show/Hide
|
C27H32F3N3O
|
1
|
| 1 |
IC50 = 12100 nM
|
|
|
|
CP0445921
|
3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)amino)methyl)-N-(2,3-dimethylphenyl)-1H-pyrazol-5-amine
Show/Hide
|
C27H33F3N4
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0445924
|
4-isopropyl-2-(naphthalen-1-ylmethyl)thiazole
Show/Hide
|
C17H17NS
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0453251
|
4-tert-butyl-N-quinolin-8-yl-1,3-thiazol-2-amine
Show/Hide
|
C16H17N3S
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0509466
|
N,4-dimethyl-N-naphthalen-1-yl-1,3-thiazol-2-amine
Show/Hide
|
C15H14N2S
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0527074
|
4-tert-butyl-N-(naphthalen-1-yl)pyrimidin-2-amine
Show/Hide
|
C18H19N3
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0553737
|
4-(aminomethyl)-N-(naphthalen-1-yl)thiazol-2-amine
Show/Hide
|
C14H13N3S
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
