| Compound ID |
Compound Name |
Compound Formula |
|
CP0055446
|
2,2,2-trifluoroethyl 3-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
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C20H19F3N6O3
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
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CP0415949
|
[3-(trifluoromethyl)oxetan-3-yl] (3R)-4-[5-[(2-fluoro-4-methylsulfonyloxyphenyl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
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|
C22H24F4N4O7S
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
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CP0480351
|
5-[(3R)-4-[5-[(2-fluoro-4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-3-(trifluoromethyl)-1,2,4-oxadiazole
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|
C20H20F4N6O4S
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
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CP0259933
|
tert-butyl (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
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|
C21H26N6O3
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
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CP0259466
|
tert-butyl 4-[5-[(4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
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|
C21H28N4O5S
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
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CP0411264
|
[3-fluoro-4-[[2-[(2R)-2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]phenyl] methanesulfonate
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|
C20H20F4N6O5S
|
1
|
| 1 |
EC50 = 42 nM
|
|
|
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CP0385919
|
4-[[2-[8-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
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|
C22H24N8O2
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0025099
|
4-[[2-[(2R)-2-methyl-4-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)piperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
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|
C21H24N8O2
|
1
|
| 1 |
EC50 = 56 nM
|
|
|
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CP0411262
|
2-[(3R)-4-[5-[[2-fluoro-4-(tetrazol-1-yl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-5-(trifluoromethyl)-1,3,4-oxadiazole
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|
C20H18F4N10O2
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
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CP0413483
|
5-[(3R)-4-[5-[(2-fluoro-4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole
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|
C22H27FN6O4S
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0244907
|
5-[(3R)-4-[5-[[2-fluoro-4-(methylsulfonylmethyl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-3-(trifluoromethyl)-1,2,4-oxadiazole
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|
C21H22F4N6O4S
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
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CP0411263
|
4-[[2-[(2R)-2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]benzene-1,3-dicarbonitrile
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|
C21H17F3N8O2
|
1
|
| 1 |
EC50 = 72 nM
|
|
|
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CP0433550
|
[3-(trifluoromethyl)oxetan-3-yl] (3R)-4-[5-[(2-fluoro-4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
Show/Hide
|
C22H24F4N4O6S
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0247411
|
tert-butyl (3R)-3-methyl-4-[5-[(4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
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|
C22H30N4O5S
|
1
|
| 1 |
EC50 = 84 nM
|
|
|
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CP0508628
|
(2,2,3,3-tetrafluorocyclobutyl) (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
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|
C21H20F4N6O3
|
1
|
| 1 |
EC50 = 84 nM
|
|
|
|
CP0398137
|
5-[(3R)-4-[5-[[2-fluoro-4-(methylsulfinylmethyl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-3-(trifluoromethyl)-1,2,4-oxadiazole
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|
C21H22F4N6O3S
|
1
|
| 1 |
EC50 = 106 nM
|
|
|
|
CP0385918
|
tert-butyl 4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
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|
C20H24N6O3
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
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CP0378664
|
[3-(trifluoromethyl)oxetan-3-yl] (3R)-4-[5-[[2-fluoro-4-(methylsulfonylmethyl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
Show/Hide
|
C23H26F4N4O6S
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
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CP0475973
|
2-[(3R)-4-[5-[(2-fluoro-4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-5-(trifluoromethyl)-1,3,4-oxadiazole
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|
C20H20F4N6O4S
|
1
|
| 1 |
EC50 = 144 nM
|
|
|
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CP0415950
|
5-[(3R)-4-[5-[[2-fluoro-4-(methylsulfonylmethyl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole
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|
C23H29FN6O4S
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
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CP0473962
|
3-fluoro-4-[[2-[(2R)-2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]benzonitrile
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|
C20H17F4N7O2
|
1
|
| 1 |
EC50 = 216 nM
|
|
|
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CP0515234
|
4-[[2-[4-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)piperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
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|
C20H22N8O2
|
1
|
| 1 |
EC50 = 242 nM
|
|
|
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CP0091258
|
2,2,2-trifluoroethyl (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
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|
C19H19F3N6O3
|
1
|
| 1 |
EC50 = 246 nM
|
|
|
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CP0473961
|
2-[(3R)-4-[5-[[2-fluoro-4-(methylsulfonylmethyl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-5-(trifluoromethyl)-1,3,4-oxadiazole
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|
C21H22F4N6O4S
|
1
|
| 1 |
EC50 = 249 nM
|
|
|
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CP0478423
|
(2,2,3,3-tetrafluorocyclobutyl) 4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
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|
C20H18F4N6O3
|
1
|
| 1 |
EC50 = 252 nM
|
|
|
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CP0455991
|
2-[(3R)-3-methyl-4-[5-[(4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]piperazin-1-yl]-5-(trifluoromethyl)-1,3,4-oxadiazole
Show/Hide
|
C20H21F3N6O4S
|
1
|
| 1 |
EC50 = 297 nM
|
|
|
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CP0378657
|
2-[(3R)-3-methyl-4-[5-[[4-(methylsulfonylmethyl)phenyl]methoxy]pyrimidin-2-yl]piperazin-1-yl]-5-(trifluoromethyl)-1,3,4-oxadiazole
Show/Hide
|
C21H23F3N6O4S
|
1
|
| 1 |
EC50 = 319 nM
|
|
|
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CP0480128
|
[3-fluoro-4-[[2-[(2R)-2-methyl-4-[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]phenyl]imino-dimethyl-oxo-lambda6-sulfane
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|
C21H23F4N7O3S
|
1
|
| 1 |
EC50 = 389 nM
|
|
|
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CP0121403
|
4-[[2-[(2R)-2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
Show/Hide
|
C19H17F3N8O2
|
1
|
| 1 |
EC50 = 436 nM
|
|
|
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CP0378567
|
[3-fluoro-4-[[2-[(2R)-2-methyl-4-[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]phenyl]methyl-imino-methyl-oxo-lambda6-sulfane
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|
C21H23F4N7O3S
|
1
|
| 1 |
EC50 = 492 nM
|
|
|
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CP0055447
|
2,2,2-trifluoroethyl 4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
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|
C18H17F3N6O3
|
1
|
| 1 |
EC50 = 698 nM
|
|
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CP0417926
|
2-[(3R)-4-[5-[[2-fluoro-4-(methylsulfinylmethyl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-5-(trifluoromethyl)-1,3,4-oxadiazole
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|
C21H22F4N6O3S
|
1
|
| 1 |
EC50 = 976 nM
|
|
|
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CP0378659
|
5-methylsulfonyl-2-[[2-[(2R)-2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]benzonitrile
Show/Hide
|
C21H20F3N7O4S
|
1
|
| 1 |
EC50 = 1975 nM
|
|
|
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CP0411265
|
[3-fluoro-4-[[2-[(2R)-2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]phenyl]methyl-imino-methyl-oxo-lambda6-sulfane
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|
C21H23F4N7O3S
|
1
|
| 1 |
EC50 > 5000 nM
|
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