Brief Information of the Cell Line and Protein
Cell Line ID: CL000094 , 1321N1
Synonyms
1321-N1
1321 N1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0110
Protein ID: PT00854 , Metabotropic glutamate receptor 5
Gene Name GRM5
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P41594
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000094  Protein ID: PT00854
 
Compound ID Compound Name Compound Formula
CP0090670
3-Cycloheptyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H22N4OS
 1
1
IC50 = 147 nM
   TI
   LI
   LO
   TS
CP0205004
3-Adamantan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C21H24N4OS
 1
1
IC50 = 154 nM
   TI
   LI
   LO
   TS
CP0090669
3-Cyclooctyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C19H24N4OS
 1
1
IC50 = 179 nM
   TI
   LI
   LO
   TS
CP0205005
3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H21N5OS
 1
1
IC50 = 342 nM
   TI
   LI
   LO
   TS
CP0311739
9-Dimethylamino-3-(4-ethyl-phenyl)-2-methyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C20H20N4OS
 1
1
IC50 = 344 nM
   TI
   LI
   LO
   TS
CP0170781
9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C19H18N4OS
 1
1
IC50 = 442 nM
   TI
   LI
   LO
   TS
CP0062238
9-Dimethylamino-3-(4-methyl-cyclohexyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H22N4OS
 1
1
IC50 = 592 nM
   TI
   LI
   LO
   TS
CP0352769
3-Cyclohexyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H20N4OS
 1
1
IC50 = 650 nM
   TI
   LI
   LO
   TS
CP0495704
3-cycloheptyl -9-dimethylamino-3H-5-thia-1,2,3,6-tetraazafluoren-4-one
   Show/Hide
C17H21N5OS
 1
1
IC50 = 816 nM
   TI
   LI
   LO
   TS
CP0230358
9-Dimethylamino-3-p-tolyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H16N4OS
 1
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
CP0157880
2-Butyl-9-dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C23H26N4OS
 1
1
IC50 = 901 nM
   TI
   LI
   LO
   TS
CP0500880
9-dimethylamino-3-(4'-methyl-1'-cyclohexyl)-3H-1,3,6-triazafluoren-4-one
   Show/Hide
C18H22N4O2
 1
1
IC50 = 901 nM
   TI
   LI
   LO
   TS
CP0141710
3-Cyclopentyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C16H18N4OS
 1
1
IC50 = 1160 nM
   TI
   LI
   LO
   TS
CP0192804
3-(4-Bromo-phenyl)-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H13BrN4OS
 1
1
IC50 = 1250 nM
   TI
   LI
   LO
   TS
CP0170784
3-(4-Chloro-phenyl)-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H13ClN4OS
 1
1
IC50 = 1810 nM
   TI
   LI
   LO
   TS
CP0205007
9-Dimethylamino-3-(4-propyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C20H20N4OS
 1
1
IC50 = 2040 nM
   TI
   LI
   LO
   TS
CP0192800
9-(1'-cyanomethylamino)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triaza-fluoren-4-one
   Show/Hide
C19H15N5OS
 1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0170776
9-Dimethylamino-3-(3-methyl-cyclohexyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H22N4OS
 1
1
IC50 = 2160 nM
   TI
   LI
   LO
   TS
CP0467950
9-dimethylamino-3-(4-ethylphenyl)-3H-5-thia-1,3,7-triazafluoren-4-one
   Show/Hide
C19H18N4OS
 1
1
IC50 = 2160 nM
   TI
   LI
   LO
   TS
CP0157879
9-(Ethyl-methyl-amino)-3-(4-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C20H20N4OS
 1
1
IC50 = 2570 nM
   TI
   LI
   LO
   TS
CP0522855
6-methyl-1-phenyl-5-(piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C17H19N5O
 1
1
IC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0170651
9-Dimethylamino-3-(4-isopropyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C20H20N4OS
 1
1
IC50 = 3540 nM
   TI
   LI
   LO
   TS
CP0457456
5-(azepan-1-yl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C18H21N5O
 1
1
IC50 = 3600 nM
   TI
   LI
   LO
   TS
CP0444563
9-dimethylamino-3-(4-methylphenyl)-3H-5-thia-1,3,7-triazafluoren-4-one
   Show/Hide
C18H16N4OS
 1
1
IC50 = 4040 nM
   TI
   LI
   LO
   TS
CP0311737
9-Dimethylamino-2-ethyl-3-(4-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C21H22N4OS
 1
1
IC50 = 4530 nM
   TI
   LI
   LO
   TS
CP0157884
3-(4-Cyclopropyl-phenyl)-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C20H18N4OS
 1
1
IC50 = 4620 nM
   TI
   LI
   LO
   TS
CP0062233
3-(4-Ethyl-phenyl)-9-methylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H16N4OS
 1
1
IC50 = 5960 nM
   TI
   LI
   LO
   TS
CP0524240
5-(4-chlorophenyl)-6-methyl-1-o-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C19H15ClN4O
 1
1
IC50 = 9500 nM
   TI
   LI
   LO
   TS
CP0520181
5-(4-chlorophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C18H13ClN4O
 1
1
IC50 = 9600 nM
   TI
   LI
   LO
   TS
CP0090673
9-Dimethylamino-3-(4-fluoro-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H13FN4OS
 1
1
IC50 = 11300 nM
   TI
   LI
   LO
   TS
CP0421801
5-(4-bromophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C18H13BrN4O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0421802
3-(5-(4-chlorophenyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[3,4-d]pyrimidin-1-yl)benzenesulfonamide
   Show/Hide
C18H14ClN5O3S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0452775
1-(3-chlorophenyl)-5-(4-chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C18H12Cl2N4O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0457567
6-methyl-1,5-di(pyrazin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C14H10N8O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0467187
1,5-bis(4-chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C18H12Cl2N4O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0490351
5-(4-chlorophenyl)-6-methyl-1-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C17H12ClN5O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0490352
5-(4-chlorophenyl)-6-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C17H12ClN5O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0490353
5-(4-chloro-3-fluorophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C18H12ClFN4O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0516413
5-(4-chlorophenyl)-1-(cyclohexylmethyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C19H21ClN4O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0520182
5-(4-chlorophenyl)-6-methyl-1-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C16H11ClN6O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0520183
5-(4-chlorophenyl)-1-cycloheptyl-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C19H21ClN4O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0520184
5-(4-chlorophenyl)-6-methyl-1-m-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C19H15ClN4O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0522854
4-(5-(4-chlorophenyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[3,4-d]pyrimidin-1-yl)benzenesulfonamide
   Show/Hide
C18H14ClN5O3S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0522856
6-methyl-1-phenyl-5-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C19H13F3N4O2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0524241
5-(4-hydroxyphenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
   Show/Hide
C18H14N4O2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0530323
4-(6-methyl-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)benzenesulfonamide
   Show/Hide
C18H15N5O3S
 1
1
IC50 = 100000 nM
   TI
   LI
   LO
   TS
CP0062234
9-dimethylamino-3-phenyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H14N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0062235
9-(N,N,-dimethyl-N-oxyamino)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
   Show/Hide
C19H18N4O2S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0062241
3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H16N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0062247
9-Dimethylamino-3-(2,4-dimethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C19H18N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0090663
3-(4-Ethyl-phenyl)-9-(2,2,2-trifluoro-ethylamino)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C19H15F3N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0090667
3-(4-ethylphenyl)-9-[(2-methoxyethyl)(methyl)amino]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
   Show/Hide
C21H22N4O2S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0090668
3-Cyclohexylmethyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H22N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0090672
9-Dimethylamino-3-(2-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C19H18N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0090674
9-Dimethylamino-3-(2-hydroxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H14N4O2S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0134999
9-Cyclopropylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C20H18N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0141712
9-Dimethylamino-3-(3-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C19H18N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0157875
9-Azetidin-1-yl-3-(4-ethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C20H18N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0157881
3-Cyclopentylmethyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H20N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0157883
3-Cyclopropyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C14H14N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0157885
3-(4-tert-Butyl-phenyl)-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C21H22N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0170646
9-Dimethylamino-3-(1-ethyl-propyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C16H20N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0170653
3-(2,4-Dichloro-phenyl)-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H12Cl2N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0205006
9-Dimethylamino-3-(2-methyl-cyclohexyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H22N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0311742
3-Cyclobutyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C15H16N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0352702
9-Dimethylamino-3-(4-trifluoromethyl-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C18H13F3N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0427582
9-dimethylamino-3-(1H-indazol-6-yl)-3H-5-thia-1,3,6-triazafluoren-4-one
   Show/Hide
C18H14N6OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0444561
9-dimethylamino-3-(4-cyclohexylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
   Show/Hide
C23H24N4OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0444564
9-dimethylamino-3-(4-ethylphenyl)-3H-5-thia-1,3-diazafluoren-4-one
   Show/Hide
C20H19N3OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0464417
9-Dimethylamino-3-(6-methoxy-pyridin-3-yl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
   Show/Hide
C17H15N5O2S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0505322
3-azepan-1-yl-9-(dimethylnitroryl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
   Show/Hide
C17H21N5O2S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0525967
9-dimethylamino-3-(4'-ethylphenyl)-3H-1,3,6-triazafluoren-4-one
   Show/Hide
C19H18N4O2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS