Brief Information of the Cell Line and Protein
Cell Line ID: CL000084 , SK-OV-3
Synonyms
SKOV-3
SK-OV3
SK.OV.3
SKOV3
Skov3
SKO3
SKOV3 (S)
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0532
Protein ID: PT01233 , Receptor tyrosine-protein kinase erbB-2
Gene Name ERBB2
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P04626
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000084  Protein ID: PT01233
 
Compound ID Compound Name Compound Formula
CP0041166
5-{[(5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-4-methyl-N-[2-(morpholin-4-yl)ethyl]-1H-pyrrole-2-carboxamide
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C34H34N8O3
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0201108
5-{[(5Z)-4-[(3-ethynylphenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-4-methyl-N-[2-(morpholin-4-yl)ethyl]-1H-pyrrole-2-carboxamide
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C27H27N7O3
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0062561
(5Z)-4-[(1-benzyl-1H-indazol-5-yl)amino]-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-pyrrol-2-yl]methylidene}-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
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C31H28N8O3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0063852
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({5-[(4-ethylpiperazin-1-yl)carbonyl]-3-methyl-1H-pyrrol-2-yl}methylidene)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
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C25H25ClFN7O2
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0088175
5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-4-methyl-N-[2-(morpholin-4-yl)ethyl]-1H-pyrrole-2-carboxamide
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C25H25ClFN7O3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0206231
(5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-pyrrol-2-yl]methylidene}-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
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C32H29N7O3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0217755
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
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C24H23ClFN7O2
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0357546
5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-methyl-1H-pyrrole-2-carboxamide
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C25H27ClFN7O2
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0217745
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
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C19H15ClFN5O
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0084269
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-pyrrol-2-yl]methylidene}-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
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C23H20ClFN6O3
 1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CP0204735
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({5-[(3,5-dimethylpiperazin-1-yl)carbonyl]-3-methyl-1H-pyrrol-2-yl}methylidene)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
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C25H25ClFN7O2
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0255898
(5Z)-4-(2,3-dihydro-1H-inden-5-ylamino)-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-pyrrol-2-yl]methylidene}-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
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C26H26N6O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0358290
5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-4-methyl-1H-pyrrole-2-carboxylic acid
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C19H13ClFN5O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS