Brief Information of the Cell Line and Protein
Cell Line ID: CL000068 , A-549
 Cell Line Info 
Synonyms
A 549
A549
NCI-A549
A549/ATCC
A549 ATCC
A549ATCC
hA549
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0023
Protein ID: PT02042 , Cystic fibrosis transmembrane conductance regulator
 Protein Info 
Gene Name CFTR
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID P13569
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000068
 Cell Line Info 
 Protein ID: PT02042
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0061241
 Compound Info 
1-(6-benzyl-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)piperidin-3-ol
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C24H27N5O
  1
1
EC50 = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0403559
 Compound Info 
N-[2-[[6-[(4-fluorophenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]ethyl]acetamide
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C23H25FN6O
  1
1
EC50 = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0409074
 Compound Info 
6-[(4-fluorophenyl)methyl]-2-pyridin-2-yl-N-(2-pyrrolidin-1-ylethyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-amine
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C25H29FN6
  1
1
EC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0223510
 Compound Info 
N-[1-[6-[(4-chlorophenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl]acetamide
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C26H29ClN6O
  1
1
EC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0230834
 Compound Info 
2-[4-[6-[(4-methoxyphenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]acetamide
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C26H31N7O2
  1
1
EC50 = 10900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0148604
 Compound Info 
2-[4-(6-benzyl-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)piperazin-1-yl]-N,N-dimethylethanamine
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C27H35N7
  1
1
EC50 = 11700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS