Brief Information of the Cell Line and Protein
Cell Line ID: CL000067 , HCT 116
 Cell Line Info 
Synonyms
HCT-116
HCT.116
HCT_116
HCT116
HCT116wt
CoCL2
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0291
Protein ID: PT03225 , Cellular tumor antigen p53
 Protein Info 
Gene Name TP53
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID P04637
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000067
 Cell Line Info 
 Protein ID: PT03225
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0041876
 Compound Info 
(4S,5R)-Nutlin-3
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C30H30Cl2N4O4
  2
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1390 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0454237
 Compound Info 
9,11-bis(4-bromophenyl)-4,17-dimethyl-8-oxa-12,13,15,17-tetrazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,13,15-hexaene
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C26H20Br2N4O
  2
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0246368
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acid
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C28H33Cl2NO5
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0491436
 Compound Info 
(+/-)-syn-6,7-Bis(4-bromophenyl)-1-ethoxy-12-methyl-7,12-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine
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C27H22Br2N4O2
  1
1
IC50 = 6500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0472023
 Compound Info 
(+/-)-syn-6,7-Bis(4-chlorophenyl)-12-methyl-7,12-dihydro-6Hchromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine
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C25H18Cl2N4O
  1
1
IC50 = 9370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455321
 Compound Info 
(+/-)-syn-6,7-Bis(4-bromophenyl)-3-fluoro-2,12-dimethyl-7,12-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine
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C26H19Br2FN4O
  1
1
IC50 = 11400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480055
 Compound Info 
(+/-)-syn-7-(4-Bromophenyl)-6-(4-chlorophenyl)-12-methyl-7,12-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine
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C25H18BrClN4O
  1
1
IC50 = 15000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0472021
 Compound Info 
(+/-)-syn-6,7-Bis(4-bromophenyl)-2-fluoro-12-methyl-7,12-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine
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C25H17Br2FN4O
  1
1
IC50 = 44300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0068001
 Compound Info 
US8653092, 67
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C21H25F3N6O2
  1
1
IC50 > 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS