Brief Information of the Cell Line and Protein
Cell Line ID: CL000063 , Hep-G2
Synonyms
HEP-G2
Hep G2
HEP G2
HepG2
HEPG2
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0027
Protein ID: PT03887 , Squalene monooxygenase
Gene Name SQLE
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID Q14534
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000063  Protein ID: PT03887
 
Compound ID Compound Name Compound Formula
CP0402849
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylthiophene-2-sulfonamide
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C25H34N2O3S2
 3
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
2
IC50 = 60 nM
   TI
   LI
   LO
   TS
3
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0511406
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-ethylthiophene-2-sulfonamide
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C26H36N2O3S2
 1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
CP0521845
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-4-thiophen-3-ylthiophene-2-sulfonamide
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C29H36N2O3S3
 1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
CP0528979
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylpyridine-3-sulfonamide
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C26H35N3O3S
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0382953
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-propylthiophene-2-sulfonamide
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C27H38N2O3S2
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0402838
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-1,3-thiazole-2-sulfonamide
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C24H33N3O3S2
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0395170
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-1-thiophen-2-ylmethanesulfonamide
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C26H36N2O3S2
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0476703
4-Cyano-N-[2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-N-methyl-benzenesulfonamide
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C28H35N3O3S
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0491724
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-5-thiophen-3-ylthiophene-2-sulfonamide
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C29H36N2O3S3
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0527471
N-cyclopropyl-N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]thiophene-2-sulfonamide
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C27H36N2O3S2
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0476695
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methylthiophene-3-sulfonamide
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C25H34N2O3S2
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0511646
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-4-fluoro-N-methylbenzenesulfonamide
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C27H35FN2O3S
 1
1
IC50 = 255 nM
   TI
   LI
   LO
   TS
CP0535451
((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-{3-[3-(thiophene-2-sulfonyl)-propoxy]-benzyl}-amine
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C25H33NO3S2
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0509995
4-Bromo-thiophene-2-sulfonic acid [2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-methyl-amide
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C25H33BrN2O3S2
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0509959
4-Bromo-N-[2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-N-methyl-benzenesulfonamide
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C27H35BrN2O3S
 1
1
IC50 = 330 nM
   TI
   LI
   LO
   TS
CP0498325
5-Bromo-thiophene-2-sulfonic acid [2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-methyl-amide
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C25H33BrN2O3S2
 1
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
CP0389418
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]thiophene-2-sulfonamide
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C24H32N2O3S2
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0402614
Benzo[b]thiophene-2-sulfonic acid [2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-methyl-amide
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C29H36N2O3S2
 1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0503070
N-[3-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]propyl]-N-methylthiophene-2-sulfonamide
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C26H36N2O3S2
 1
1
IC50 = 6400 nM
   TI
   LI
   LO
   TS
CP0540164
N-[2-[3-[[[(E)-6,6-dimethylhept-2-en-4-ynyl]-ethylamino]methyl]phenoxy]ethyl]-N-methyl-5-thiophen-2-ylthiophene-2-sulfonamide
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C29H36N2O3S3
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS