| Compound ID |
Compound Name |
Compound Formula |
|
CP0119008
|
4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5- yl)ethyl)-N-phenylpiperidine-1-carboxamide
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|
C24H26N4O2
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0119011
|
(1R,4r)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol
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|
C18H21FN2O2
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0098775
|
1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)-2-phenylethanone;
Show/Hide
|
C25H27N3O2
|
1
|
| 1 |
EC50 = 78 nM
|
|
|
|
CP0119009
|
N-((1s,4s)-4-(1-hydroxy-2-(5H-imidazo[5,1- a]isoindol-5-yl)ethyl)cyclohexyl)benzamide
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|
C25H27N3O2
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0266145
|
1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]isoindol-5-yl)ethanol;
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|
C18H20F2N2O
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0102032
|
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
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|
C18H22N2O
|
1
|
| 1 |
EC50 = 83 nM
|
|
|
|
CP0119002
|
N-((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1- a]isoindol-5-yl)ethyl)cyclohexyl)benzamide
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|
C25H27N3O2
|
1
|
| 1 |
EC50 = 86 nM
|
|
|
|
CP0098778
|
1-(4,4-difluorocyclohexyl)-2-(6-fluoro-5H- imidazo[5,1-a]isoindol-5-yl)ethanol;
Show/Hide
|
C18H19F3N2O
|
1
|
| 1 |
EC50 = 93 nM
|
|
|
|
CP0204650
|
2-(4-fluorophenyl)-1-(4-(1-hydroxy-2-(5H- imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1- yl)ethanone
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|
C25H26FN3O2
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0119013
|
(1S,4s)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol
Show/Hide
|
C18H21FN2O2
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0098779
|
4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)- 1-hydroxyethyl)cyclohexanone;
Show/Hide
|
C18H19FN2O2
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0169133
|
1-cyclohexyl-2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)ethanol
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|
C18H21FN2O
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0119006
|
CHEMBL4461858
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|
C20H24N2O3
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0158824
|
(1S,4r)-4-((S)-2-((S)-6-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol
Show/Hide
|
C18H21FN2O2
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0361245
|
1-cyclohexyl-3-(5H-imidazo[5,1-a]isoindol-5- yl)propan-2-ol;
Show/Hide
|
C19H24N2O
|
1
|
| 1 |
EC50 = 230 nM
|
|
|
|
CP0541125
|
US10233190, Example 1363
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|
C22H29N3O3
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0119010
|
4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)- 1-hydroxyethyl)cyclohexanol;
Show/Hide
|
C18H21FN2O2
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0063998
|
US10233190, Example 1425
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|
C24H31N3O2
|
1
|
| 1 |
EC50 = 330 nM
|
|
|
|
CP0119004
|
1-cyclohexyl-2-(7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)ethanol
Show/Hide
|
C18H21FN2O
|
1
|
| 1 |
EC50 = 340 nM
|
|
|
|
CP0098771
|
2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-4- yl)ethanol
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|
C17H15N3O
|
1
|
| 1 |
EC50 = 390 nM
|
|
|
|
CP0361249
|
US10233190, Example 1460
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|
C20H25N3O3
|
1
|
| 1 |
EC50 = 490 nM
|
|
|
|
CP0222969
|
2-(5H-imidazo[5,1-a]isoindol-5-yl)-1- (tetrahydro-2H-pyran-4-yl)ethanol
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|
C17H20N2O2
|
1
|
| 1 |
EC50 = 510 nM
|
|
|
|
CP0159004
|
2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-5- yl)ethanol;
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|
C15H13N3OS
|
1
|
| 1 |
EC50 = 760 nM
|
|
|
|
CP0204648
|
1-cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5- yl)ethanol
Show/Hide
|
C17H20N2O
|
1
|
| 1 |
EC50 = 780 nM
|
|
|
|
CP0204649
|
2-(5H-imidazo[5,1-a]isoindol-5-yl)-1- phenylethanol
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|
C18H16N2O
|
1
|
| 1 |
EC50 = 820 nM
|
|
|
|
CP0118993
|
4-chloro-2-(1H-imidazol-5-yl)phenol
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|
C9H7ClN2O
|
1
|
| 1 |
EC50 = 940 nM
|
|
|
|
CP0119007
|
1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)ethanone;
Show/Hide
|
C19H23N3O2
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0369249
|
5-(2-cyclohexylethyl)-5H-imidazo[5,1-a]isoindole
Show/Hide
|
C18H22N2
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0204658
|
1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)-2-(pyridin-4- yl)ethanone
Show/Hide
|
C24H26N4O2
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0369248
|
4-bromo-2-(1H-imidazol-5-yl)phenol
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|
C9H7BrN2O
|
1
|
| 1 |
EC50 = 1700 nM
|
|
|
|
CP0234124
|
2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyclohexylethanol
Show/Hide
|
C18H21ClN2O
|
1
|
| 1 |
EC50 = 1900 nM
|
|
|
|
CP0384248
|
4-chloro-2-fluoro-6-(1H-imidazol-5-yl)phenol
Show/Hide
|
C9H6ClFN2O
|
1
|
| 1 |
EC50 = 1900 nM
|
|
|
|
CP0266144
|
2-(7-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyclohexylethanol
Show/Hide
|
C18H21ClN2O
|
1
|
| 1 |
EC50 = 2200 nM
|
|
|
|
CP0361242
|
2-(1H-imidazol-5-yl)-4-methylphenol
Show/Hide
|
C10H10N2O
|
1
|
| 1 |
EC50 = 2400 nM
|
|
|
|
CP0119005
|
1-cyclohexyl-2-(8-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)ethanol;
Show/Hide
|
C18H21FN2O
|
1
|
| 1 |
EC50 = 2700 nM
|
|
|
|
CP0164767
|
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5- yl)ethanamine
Show/Hide
|
C18H23N3
|
1
|
| 1 |
EC50 = 3100 nM
|
|
|
|
CP0118998
|
1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)-2-(pyrimidin-5- yl)ethanone
Show/Hide
|
C23H25N5O2
|
1
|
| 1 |
EC50 = 3800 nM
|
|
|
|
CP0324896
|
2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-methylpyrazol-4-yl)ethanol
Show/Hide
|
C16H16N4O
|
1
|
| 1 |
EC50 = 4200 nM
|
|
|
|
CP0118999
|
2-(8-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyclohexylethanol;
Show/Hide
|
C18H21ClN2O
|
1
|
| 1 |
EC50 = 5400 nM
|
|
|
|
CP0327840
|
2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
Show/Hide
|
C12H12N2O
|
1
|
| 1 |
EC50 = 5900 nM
|
|
|
|
CP0159001
|
4-chloro-2-(3-cyclohexylimidazol-4-yl)phenol
Show/Hide
|
C15H17ClN2O
|
1
|
| 1 |
EC50 = 6100 nM
|
|
|
|
CP0204647
|
1-(5H-imidazo[5,1-a]isoindol-5-yl)-2- methylpropan-2-ol
Show/Hide
|
C14H16N2O
|
1
|
| 1 |
EC50 = 6700 nM
|
|
|
|
CP0090856
|
2-(1H-imidazol-4-yl)phenol
Show/Hide
|
C9H8N2O
|
1
|
| 1 |
EC50 = 7200 nM
|
|
|
|
CP0324895
|
5H-imidazo[5,1-a]isoindol-9-ol
Show/Hide
|
C10H8N2O
|
1
|
| 1 |
EC50 = 7900 nM
|
|
|
|
CP0063996
|
2-(5H-imidazo[5,1-a]isoindol-5-yl)-1- phenylethanone
Show/Hide
|
C18H14N2O
|
1
|
| 1 |
EC50 = 15000 nM
|
|
|
|
CP0243838
|
5H-imidazo[5,1-a]isoindole
Show/Hide
|
C10H8N2
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0324894
|
5-[2-(2-cyclohexylethoxy)phenyl]-1H-imidazole
Show/Hide
|
C17H22N2O
|
1
|
| 1 |
EC50 = 26000 nM
|
|
|
|
CP0182071
|
2-(1H-imidazol-4-yl)benzene-1,3-diol
Show/Hide
|
C9H8N2O2
|
1
|
| 1 |
EC50 = 60000 nM
|
|
|
|
CP0459331
|
5-[2-(2-phenylethoxy)phenyl]-1H-imidazole
Show/Hide
|
C17H16N2O
|
1
|
| 1 |
EC50 = 65000 nM
|
|
|
|
CP0164763
|
3-(2-cyclohexylethoxy)-2-(1H-imidazol-5-yl)phenol
Show/Hide
|
C17H22N2O2
|
1
|
| 1 |
EC50 = 80000 nM
|
|
|
