Brief Information of the Cell Line and Protein
Cell Line ID: CL000043 , U2OS
Synonyms
U-2 OS
U-2OS
U-2-OS
U2-OS
U20-S
U20S
2T
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0042
Protein ID: PT05980 , Exportin-1
Gene Name XPO1
Organism Homo sapiens, Human
Protein Classification Unclassified protein
Uniprot ID O14980
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000043  Protein ID: PT05980
 
Compound ID Compound Name Compound Formula
CP0848602
(Z)-3-(3-chlorophenyl)-1-(3,3,3-trifluoroprop-1-en-1-yl)-1H-1,2,4-triazole
   Show/Hide
C11H7ClF3N3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0864415
(E)-isopropyl 4-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)but-2-enoate
   Show/Hide
C15H16ClN3O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0864416
(E)-isopropyl 3-(3-(1-((Z)-3-isopropoxy-3-oxoprop-1-en-1-yl)-1H-1,2,4-triazol-3-yl)-5-(trifluoromethyl)phenoxy)acrylate
   Show/Hide
C21H22F3N3O5
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0864419
(Z)-isopropyl 3-(5-(3,5-dichlorophenyl)-1H-1,2,4-triazol-3-yl)acrylate
   Show/Hide
C14H13Cl2N3O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0864420
(Z)-ethyl 3-(3-(3,5-difluorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C13H11F2N3O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0867125
(Z)-tert-butyl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H16ClN3O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0888236
(Z)-isopropyl 4-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)but-2-enoate
   Show/Hide
C15H16ClN3O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0894747
(E)-isopropyl 3-(3-(3-(2-(dimethylamino)ethoxy)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C19H23F3N4O3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0911477
(Z)-isopropyl 3-(3-(3-chloro-4-methoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H16ClN3O3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0911479
(Z)-isopropyl 3-(3-(4-(4-chlorophenoxy)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C20H18ClN3O3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0913910
(Z)-(1H-imidazol-5-yl)methyl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H12ClN5O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0913911
(E)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile
   Show/Hide
C11H7ClN4
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0913913
(Z)-isopropyl 3-(5-(3-fluorophenyl)-4H-1,2,4-triazol-3-yl)acrylate
   Show/Hide
C14H14FN3O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0914432
(Z)-isopropyl 3-(3-(2-chlorothiazol-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C11H11ClN4O2S
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0915647
(Z)-isopropyl 3-(3-(3-chloro-5-(4-chlorophenoxy)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C20H17Cl2N3O3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0930884
(Z)-isopropyl 3-(3-(2-bromothiazol-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C11H11BrN4O2S
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0930885
3-[3-(3-Chloro-5-fluoro-phenyl)-[1,2,4]triazol-1-yl]-acrylic acid ethyl ester
   Show/Hide
C13H11ClFN3O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0943844
(Z)-5-oxotetrahydrofuran-3-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H12ClN3O4
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0960132
(E)-azetidin-3-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C14H13ClN4O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0963853
(Z)-pyrrolidin-2-ylmethyl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H17ClN4O2
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0963854
(Z)-3-(3-chlorophenyl)-1-(2-(methylsulfinyl)vinyl)-1H-1,2,4-triazole
   Show/Hide
C11H10ClN3OS
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0864418
(E)-3-[3-(3-Chloro-phenyl)-[1,2,4]-triazol-1-yl]-acrylic acid ethyl ester
   Show/Hide
C13H12ClN3O2
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0864421
(E)-N-(3-Chloro-phenyl)-3-[3-(3-chloro-phenyl)-[1,2,4]-triazol-1-yl]-acryl amide
   Show/Hide
C17H12Cl2N4O
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0869379
(E)-isopropyl 3-(3-(3-(2-(pyrrolidin-1-yl)ethoxy)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C21H25F3N4O3
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0913573
3-[5-(3-Chloro-phenyl)-1H-[1,2,4]triazol-3-yl]-N-isopropyl-N-methyl-acrylamide
   Show/Hide
C15H17ClN4O
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0913914
(E)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)-N-(4-methoxyphenyl)acrylamide
   Show/Hide
C18H15ClN4O2
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0930880
(E)-3-[3-(3-Chloro-phenyl)-[1,2,4]-triazol-1-yl]-acrylic acid isopropyl ester
   Show/Hide
C14H14ClN3O2
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0930886
(E)-N-(4-Amino-phenyl)-3-[3-(3-chloro-phenyl)-[1,2,4]-triazol-1-yl]-acrylamide
   Show/Hide
C17H14ClN5O
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0942274
(E)-3-[3-(3-Chloro-phenyl)-[1,2,4]-triazol-1-yl]-acrylic acid tert-butyl ester
   Show/Hide
C15H16ClN3O2
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0943845
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)-N-cyclopentylacrylamide
   Show/Hide
C16H17ClN4O
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0957274
(Z)-3-(5-(3-chlorophenyl)-4H-1,2,4-triazol-3-yl)-N-phenylacrylamide
   Show/Hide
C17H13ClN4O
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0957275
(Z)-3-(5-(3-chlorophenyl)-4H-1,2,4-triazol-3-yl)-N-methyl-N-phenylacrylamide
   Show/Hide
C18H15ClN4O
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0960124
(Z)-isopropyl 3-(3-(2-fluoro-[1,1'-biphenyl]-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C20H18FN3O2
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0963856
(E)-tert-butyl(4-(3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylamido)phenyl)carbamate
   Show/Hide
C22H22ClN5O3
 1
1
IC50 >= 10000 nM
   TI
   LI
   LO
   TS
CP0848600
(Z)-isopropyl 3-(3-(2-chloro-6-isopropoxypyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H19ClN4O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0848601
(Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H16ClN3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0851369
(Z)-3-[3-(3,5-Dichloro-phenyl)-[1,2,4]triazol-1-yl]-acrylic acid ethyl ester
   Show/Hide
C13H11Cl2N3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0851370
(Z)-isopropyl 3-(3-(5-chloro-2-methoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H16ClN3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0864417
(Z)-isopropyl 3-(3-(2-(isopropylamino)-6-(trifluoromethyl)pyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C17H20F3N5O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0864444
(Z)-isopropyl 3-(3-(3,5-dimethoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H19N3O4
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0864445
(Z)-cyclohexyl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C17H18ClN3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0867123
(Z)-isopropyl 3-(3-(3-chloro-5-methoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H16ClN3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0867124
(Z)-cyclobutyl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H14ClN3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0867126
(Z)-isopropyl 3-(3-(3-(2-(pyrrolidin-1-yl)ethoxy)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C21H25F3N4O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0867127
(Z)-isopropyl 3-(3-(3-chloro-5-(2-methoxyethoxy)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C17H20ClN3O4
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0867128
(Z)-3-[3-(3-Chloro-phenyl)-[1,2,4]triazol-1-yl]-acrylic acid phenyl ester
   Show/Hide
C17H12ClN3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0875186
(Z)-pyridin-2-ylmethyl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C17H13ClN4O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0875187
(Z)-isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H16F3N3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0875188
(Z)-3-[5-(3-Chloro-phenyl)-1H-[1,2,4]triazol-3-yl]-acrylic acid isopropyl ester
   Show/Hide
C14H14ClN3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0888235
(Z)-isopropyl 3-(3-(5-chloropyridin-3-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C13H13ClN4O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0894748
(Z)-azetidin-3-yl 3-(3-(2,6-dichloropyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C13H11Cl2N5O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0906037
(Z)-isopropyl 3-(3-(2-chloro-6-(isopropylamino)pyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H20ClN5O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0911124
(Z)-3-[3-(3-Chloro-phenyl)-[1,2,4]-triazol-1-yl]-acrylic acid isopropyl ester
   Show/Hide
C14H14ClN3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0911125
(Z)-cyclopentyl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H16ClN3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0911478
(Z)-isopropyl 3-(3-(3,4-dichlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C14H13Cl2N3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0913569
(Z)-isopropyl 3-(3-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H14F3N3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0913570
(Z)-isopropyl 3-(3-(5-chlorothiophen-3-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C12H12ClN3O2S
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0913571
(Z)-isopropyl 3-(3-(2-(cyclobutylamino)-6-(trifluoromethyl)pyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C18H20F3N5O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0913572
(Z)-3-[3-(3-Chloro-phenyl)-[1,2,4]-triazol-1-yl]-acrylic acid ethyl ester
   Show/Hide
C13H12ClN3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0913909
(Z)-3-(3-chlorophenyl)-1-(2-(methylsulfonyl)vinyl)-1H-1,2,4-triazole
   Show/Hide
C11H10ClN3O2S
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0913912
3-[3-(2-Amino-5-chloro-phenyl)-[1,2,4]triazol-1-yl]-acrylic acid isopropyl ester
   Show/Hide
C14H15ClN4O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0913915
(Z)-isopropyl 3-(3-(4-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C14H14ClN3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0914430
(Z)-isopropyl 3-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H13ClF3N3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0914431
(Z)-isopropyl 3-(3-(3-cyano-5-isopropoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C18H20N4O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0915648
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile
   Show/Hide
C11H7ClN4
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0930881
(Z)-1-(azetidin-1-yl)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)prop-2-en-1-one
   Show/Hide
C14H13ClN4O
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0930882
(Z)-isopropyl 3-(3-(m-tolyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H17N3O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0930883
(Z)-isopropyl 3-(3-(3-(2-(dimethylamino)ethoxy)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C19H23F3N4O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0943846
(Z)-tetrahydrofuran-3-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H14ClN3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0943847
(Z)-azetidin-3-yl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H15F3N4O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0945324
(Z)-oxetan-3-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C14H12ClN3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0945325
(Z)-isopropyl 3-(3-(3-(methylsulfonyl)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C16H16F3N3O4S
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0947212
(Z)-isopropyl 3-(3-(2-chloro-6-methoxypyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C14H15ClN4O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0948694
(Z)-methyl 3-(3-(3-chloro-5-methoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C13H12ClN3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0949340
(Z)-isopropyl 3-(3-(3-chloro-5-(methylamino)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C15H17ClN4O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0949343
(Z)-isopropyl 3-(3-(2-isopropoxy-6-(trifluoromethyl)pyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C17H19F3N4O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0957272
(Z)-isopropyl 3-(3-(2,6-dichloropyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C13H12Cl2N4O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0957273
(Z)-isopropyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
   Show/Hide
C18H20F3N3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0960125
(Z)-ethyl 3-(3-(3-chloro-5-ethoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate
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C14H14ClN3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0960130
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile
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C15H13F3N4O
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0960134
(Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
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C21H19F3N4O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0963851
(Z)-isopropyl 3-(3-(3-chloro-5-isopropoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate
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C17H20ClN3O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0963852
(Z)-azetidin-3-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
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C14H13ClN4O2
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS
CP0963855
(Z)-pyridin-2-ylmethyl 3-(3-(2-isopropoxy-6-(trifluoromethyl)pyridin-4-yl)-1H-1,2,4-triazol-1-yl)acrylate
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C20H18F3N5O3
 1
1
IC50 <= 1000 nM
   TI
   LI
   LO
   TS