Brief Information of the Cell Line and Protein
Cell Line ID: CL000043 , U2OS
Synonyms
U-2 OS
U-2OS
U-2-OS
U2-OS
U20-S
U20S
2T
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0042
Protein ID: PT05171 , C-X-C chemokine receptor type 3
Gene Name CXCR3
Organism Mus musculus, Mouse
Protein Classification Membrane receptor
Uniprot ID O88410
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000043  Protein ID: PT05171
 
Compound ID Compound Name Compound Formula
CP0878614
(1S,4R)-1-(((S)-4-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-3-methylpiperazin-1-ylsulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-ol
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C21H29F4N3O3S
 1
1
IC50 = 158.49 nM
   TI
   LI
   LO
   TS
CP0162997
(1S,2S,4R)-1-(((S)-4-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-3-methylpiperazin-1-ylsulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-ol
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C21H29F4N3O3S
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0493556
(1S,2S,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-ol
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C21H30F3N3O3S
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0170956
(1S,4R)-1-(((S)-4-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-3-methylpiperazin-1-ylsulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
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C21H27F4N3O3S
 1
1
IC50 = 501.19 nM
   TI
   LI
   LO
   TS
CP0493557
(1S,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-ol
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C21H30F3N3O3S
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0525944
(1S,2R,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-ol
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C21H30F3N3O3S
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0453623
(1S,4R)-1-[[4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
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C20H25F4N3O3S
 1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0472356
(1S,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
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C20H27F3N4O3S
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0459495
(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
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C20H26F3N3O3S
 1
1
IC50 = 1258.93 nM
   TI
   LI
   LO
   TS
CP0460060
(2S)-4-[[(1'S,4'R)-7',7'-dimethylspiro[1,3-dioxolane-2,2'-bicyclo[2.2.1]heptane]-1'-yl]methylsulfonyl]-1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-2-methylpiperazine
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C23H31F4N3O4S
 1
1
IC50 = 1584.89 nM
   TI
   LI
   LO
   TS
CP0478448
(1S,2R,4R)-1-[[(3S)-4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-3-methylpiperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol
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C21H29F4N3O3S
 1
1
IC50 = 1584.89 nM
   TI
   LI
   LO
   TS
CP0441617
(1S,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
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C21H28F3N3O3S
 1
1
IC50 = 2511.89 nM
   TI
   LI
   LO
   TS
CP0486598
(1S,4R)-1-[[(3S)-4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-3-(hydroxymethyl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
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C21H27F4N3O4S
 1
1
IC50 = 6309.57 nM
   TI
   LI
   LO
   TS