Brief Information of the Cell Line and Protein
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Synonyms
U-2 OS
U-2OS
U-2-OS
U2-OS
U20-S
U20S
2T
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0042
Protein ID: PT04361 , Protein smoothened
 Protein Info 
Gene Name SMO
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q99835
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000043
 Cell Line Info 
 Protein ID: PT04361
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0416601
 Compound Info 
N-(2-methylcyclohexyl)-1-[5-[5-[[(5-methylpyridin-2-yl)amino]methyl]pyrazol-1-yl]-1,3,4-thiadiazol-2-yl]piperidine-4-carboxamide
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C25H34N8OS
  1
1
IC50 = 3.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464239
 Compound Info 
N-[5-(2-acetamido-1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]benzamide
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C21H15ClN4O2S
  1
1
IC50 = 5.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0062721
 Compound Info 
N-[5-(2-acetamido-1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-3-chlorobenzamide
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C21H14Cl2N4O2S
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0444038
 Compound Info 
1-[5-[5-[(4-methylanilino)methyl]pyrazol-1-yl]-1,3,4-thiadiazol-2-yl]-N-(2-methylcyclohexyl)piperidine-4-carboxamide
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C26H35N7OS
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0068085
 Compound Info 
2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide
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C19H14Cl2N2O3S
  1
1
IC50 = 74 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429492
 Compound Info 
N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-carbazole-2-carboxamide
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C25H19FN4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS