Brief Information of the Cell Line and Protein
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Synonyms
U-2 OS
U-2OS
U-2-OS
U2-OS
U20-S
U20S
2T
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0042
Protein ID: PT01410 , Substance-P receptor
 Protein Info 
Gene Name TACR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P25103
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000043
 Cell Line Info 
 Protein ID: PT01410
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0851343
 Compound Info 
(2S,5S,7R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-2-(hydroxymethyl)-N,2-dimethyl-1,8-diazaspiro[4.5]decane-8-carboxamide hydrochloride
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C29H35ClF7N3O2
  1
1
Ki < 1 nM
 Bioactivity Info 
   TI
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CP0883064
 Compound Info 
(2R,4S,8a'R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylhexahydro-1Hspiro[piperidine-4,6'-pyrrolo[2,1-c][1,4]oxazine]-1-carboxamide hydrochloride
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C30H35ClF7N3O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0883065
 Compound Info 
(2R,5S,7R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-2-(hydroxymethyl)-N-methyl-1,8-diazaspiro[4.5]decane-8-carboxamide hydrochloride
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C28H33ClF7N3O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0883066
 Compound Info 
(2R,5S,7R)-N8-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8,2-dimethyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide hydrochloride
   Show/Hide
C29H34ClF7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0883067
 Compound Info 
(2R,5S,7R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-2-(hydroxymethyl)-N,2-dimethyl-1,8-diazaspiro[4.5]decane-8-carboxamide hydrochloride
   Show/Hide
C29H35ClF7N3O2
  1
1
Ki < 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0883068
 Compound Info 
(2S,5S,7R)-N8-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide
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C28H31F7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0883069
 Compound Info 
(5R,7R)-N8-{(1R)-1-[3,5-(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide
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C28H31F7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0927955
 Compound Info 
(5S,7R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N-methyl-1,8-diazaspiro[4.5]decane-8-carboxamide
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C27H30F7N3O
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0927956
 Compound Info 
Sodium(5S,7R)-8-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-3-carboxylate
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C28H29F7N3NaO3
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0927957
 Compound Info 
(2R,5S,7R)-N8-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide
   Show/Hide
C28H31F7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0927958
 Compound Info 
(2S,5S,7R)-N8-{[3,5-bis(trifluoromethyl)phenyl]methyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide
   Show/Hide
C27H29F7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0927959
 Compound Info 
(2R,5S,7R)-N8-{[3,5-bis(trifluoromethyl)phenyl]methyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide
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C27H29F7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0945392
 Compound Info 
(2S,5S,7R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-2-(hydroxymethyl)-N-methyl-1,8-diazaspiro[4.5]decane-8-carboxamide hydrochloride
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C28H33ClF7N3O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0949651
 Compound Info 
(2R,4S,8a'R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N,8a'-dimethylhexahydro-1H-spiro[piperidine-4,6'-pyrrolo[2,1-c][1,4]oxazine]-1-carboxamide hydrochloride
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C31H37ClF7N3O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0950606
 Compound Info 
(2R,4S,8a'S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylhexahydro-1Hspiro[piperidine-4,6'-pyrrolo[2,1-c][1,4]oxazine]-1-carboxamide hydrochloride
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C30H35ClF7N3O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0953940
 Compound Info 
(2S,5S,7R)-N8-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide Hydrochloride
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C28H32ClF7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0955290
 Compound Info 
(2R,4S,8a'S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N,8a'-dimethylhexahydro-1Hspiro[piperidine-4,6'-pyrrolo[2,1-c][1,4]oxazine]-1-carboxamide hydrochloride
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C31H37ClF7N3O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0955300
 Compound Info 
(2S,5S,7R)-N8{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8,2-dimethyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide Hydrochloride
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C29H34ClF7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0959886
 Compound Info 
(2R,5S,7R)-N8-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide Hydrochloride
   Show/Hide
C28H32ClF7N4O2
  1
1
Ki < 1 nM
 Bioactivity Info 
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CP0967999
 Compound Info 
Lithium(4S,5R,7R)-8-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-4-carboxylate
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C28H29F7LiN3O3
  1
1
Ki < 1 nM
 Bioactivity Info 
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