Brief Information of the Cell Line and Protein
Cell Line ID: CL000035 , NIH 3T3
Synonyms
NIH/3T3
NIH-3T3
NIH3T3
3T3
3T3NIH
3T3-Swiss
Swiss-3T3
Swiss/3T3
Swiss 3T3
Swiss3T3
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0594
Protein ID: PT02415 , Sodium/glucose cotransporter 2
Gene Name SLC5A2
Organism Homo sapiens, Human
Protein Classification Transporter
Uniprot ID P31639
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000035  Protein ID: PT02415
 
Compound ID Compound Name Compound Formula
CP0469535
(3S,3'R,4'S,5'S,6'R)-5-[(5-ethylthiophen-2-yl)methyl]-6,6'-dimethylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C21H26O5S
 1
1
IC50 = 4.5 nM
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CP0198642
(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol
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C21H25ClO6
 1
1
IC50 = 8.3 nM
   TI
   LI
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CP0549450
(3S,3'R,4'S,5'S,6'R)-6-chloro-6'-methyl-5-[(5-methylthiophen-2-yl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C19H21ClO5S
 1
1
IC50 = 8.5 nM
   TI
   LI
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CP0416562
(3S,3'R,4'S,5'S,6'R)-6-chloro-5-[(4-ethoxyphenyl)methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C22H25ClO6
 1
1
IC50 = 8.8 nM
   TI
   LI
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CP0536695
(3S,3'R,4'S,5'S,6'R)-6-chloro-5-[(5-chlorothiophen-2-yl)methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C18H18Cl2O5S
 1
1
IC50 = 15.9 nM
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   LI
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CP0535759
(3S,3'R,4'S,5'S,6'R)-5-(1-benzothiophen-2-ylmethyl)-6-chloro-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C22H21ClO5S
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0476837
(3S,3'R,4'S,5'S,6'R)-5-[(5-ethylthiophen-2-yl)methyl]-6-fluoro-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C20H23FO5S
 1
1
IC50 = 26.2 nM
   TI
   LI
   LO
   TS
CP0574777
(3S,3'R,4'S,5'S,6'R)-6-chloro-5-[(4-ethylphenyl)methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C22H25ClO5
 1
1
IC50 = 29.7 nM
   TI
   LI
   LO
   TS
CP0469536
(3S,3'R,4'S,5'S,6'R)-6-chloro-6'-methyl-5-[[5-(2-propoxyethyl)thiophen-2-yl]methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C23H29ClO6S
 1
1
IC50 = 42.3 nM
   TI
   LI
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   TS
CP0558580
methyl 2-[5-[[(3S,3'R,4'S,5'S,6'R)-6-chloro-3',4',5'-trihydroxy-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-5-yl]methyl]thiophen-2-yl]acetate
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C21H23ClO7S
 1
1
IC50 = 42.4 nM
   TI
   LI
   LO
   TS
CP0541105
(3S,3'R,4'S,5'S,6'R)-6-chloro-5-[[5-(hydroxymethyl)thiophen-2-yl]methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C19H21ClO6S
 1
1
IC50 = 47.2 nM
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   TS
CP0435662
5-[[(3S,3'R,4'S,5'S,6'R)-6-chloro-3',4',5'-trihydroxy-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-5-yl]methyl]thiophene-2-carbaldehyde
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C19H19ClO6S
 1
1
IC50 = 51.3 nM
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CP0444252
methyl 5-[[(3S,3'R,4'S,5'S,6'R)-6-chloro-3',4',5'-trihydroxy-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-5-yl]methyl]thiophene-2-carboxylate
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C20H21ClO7S
 1
1
IC50 = 51.5 nM
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CP0541104
(3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C22H26O5
 1
1
IC50 = 63.5 nM
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CP0476838
(3S,3'R,4'S,5'S,6'R)-6-chloro-5-[[5-(2-ethoxyethyl)thiophen-2-yl]methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C22H27ClO6S
 1
1
IC50 = 67.5 nM
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CP0438560
(3S,3'R,4'S,5'S,6'R)-6-chloro-5-[[5-(2-methoxyethyl)thiophen-2-yl]methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C21H25ClO6S
 1
1
IC50 = 69.4 nM
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CP0384328
(3S,3'R,4'S,5'S,6'R)-6'-methyl-5-(naphthalen-2-ylmethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C24H24O5
 1
1
IC50 > 100 nM
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CP0403136
(3S,3'R,4'S,5'S,6'R)-5-[(4-methoxyphenyl)methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C21H24O6
 1
1
IC50 > 100 nM
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CP0416580
(3S,3'R,4'S,5'S,6'R)-6-chloro-5-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C24H22ClFO5S
 1
1
IC50 > 100 nM
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CP0416581
(3S,3'R,4'S,5'S,6'R)-6'-methyl-5-[(4-propan-2-ylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C23H28O5
 1
1
IC50 > 100 nM
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CP0423126
(3S,3'R,4'S,5'S,6'R)-5-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C24H23FO5S
 1
1
IC50 > 100 nM
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   LI
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CP0423127
(3S,3'R,4'S,5'S,6'R)-5-[(4-ethoxyphenyl)methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
   Show/Hide
C22H26O6
 1
1
IC50 > 100 nM
   TI
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   TS
CP0427123
(3S,3'R,4'S,5'S,6'R)-6'-methyl-5-[(5-phenylthiophen-2-yl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C24H24O5S
 1
1
IC50 > 100 nM
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   TS
CP0427322
(3S,3'R,4'S,5'S,6'R)-5-(1-benzothiophen-2-ylmethyl)-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C22H22O5S
 1
1
IC50 > 100 nM
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CP0427323
(3S,3'R,4'S,5'S,6'R)-5-[(5-chlorothiophen-2-yl)methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C18H19ClO5S
 1
1
IC50 > 100 nM
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CP0459437
(3S,3'R,4'S,5'S,6'R)-5-[(5-ethylthiophen-2-yl)methyl]-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C20H24O5S
 1
1
IC50 > 100 nM
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CP0518736
(3S,3'R,4'S,5'S,6'R)-6'-methyl-5-[(4-methylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C21H24O5
 1
1
IC50 > 100 nM
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CP0534235
(3S,3'R,4'S,5'S,6'R)-5-(1-benzofuran-2-ylmethyl)-6'-methylspiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C22H22O6
 1
1
IC50 > 100 nM
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CP0534236
(3S,3'R,4'S,5'S,6'R)-6'-methyl-5-[(5-propylthiophen-2-yl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C21H26O5S
 1
1
IC50 > 100 nM
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CP0541106
(3S,3'R,4'S,5'S,6'R)-6'-methyl-5-[(5-pyridin-2-ylthiophen-2-yl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C23H23NO5S
 1
1
IC50 > 100 nM
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CP0549461
(3S,3'R,4'S,5'S,6'R)-6'-methyl-5-[(5-methylthiophen-2-yl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C19H22O5S
 1
1
IC50 > 100 nM
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CP0570527
(3S,3'R,4'S,5'S,6'R)-6'-methyl-5-[(4-propylphenyl)methyl]spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
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C23H28O5
 1
1
IC50 > 100 nM
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