Brief Information of the Cell Line and Protein
Cell Line ID: CL000035 , NIH 3T3
Synonyms
NIH/3T3
NIH-3T3
NIH3T3
3T3
3T3NIH
3T3-Swiss
Swiss-3T3
Swiss/3T3
Swiss 3T3
Swiss3T3
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0594
Protein ID: PT01233 , Receptor tyrosine-protein kinase erbB-2
Gene Name ERBB2
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P04626
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000035  Protein ID: PT01233
 
Compound ID Compound Name Compound Formula
CP0384973
4-(2-methyl-4-(6-(pyrrolidin-1-yl)pyrido[3,4-d]pyrimidin-4-ylamino)phenoxy)-N-neopentylbenzamide
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C30H34N6O2
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0435599
3,3-dimethyl-1-(4-(2-methyl-4-(6-morpholinopyrido[3,4-d]pyrimidin-4-ylamino)phenoxy)piperidin-1-yl)butan-1-one
   Show/Hide
C29H38N6O3
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0490486
1-(4-(4-(6-(dimethylamino)pyrido[3,4-d]pyrimidin-4-ylamino)-2-methylphenoxy)piperidin-1-yl)-3,3-dimethylbutan-1-one
   Show/Hide
C27H36N6O2
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0542302
4-(4-(6-(dimethylamino)pyrido[3,4-d]pyrimidin-4-ylamino)-2-methylphenoxy)-N-neopentylbenzamide
   Show/Hide
C28H32N6O2
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0406560
4-(2-methyl-4-(6-(methylamino)pyrido[3,4-d]pyrimidin-4-ylamino)phenoxy)-N-neopentylbenzamide
   Show/Hide
C27H30N6O2
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0486204
4-(2-methyl-4-(6-(4-methylpiperazin-1-yl)pyrido[3,4-d]pyrimidin-4-ylamino)phenoxy)-N-neopentylbenzamide
   Show/Hide
C31H37N7O2
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0529746
4-(2-methyl-4-(6-(2-morpholinoethylamino)pyrido[3,4-d]pyrimidin-4-ylamino)phenoxy)-N-neopentylbenzamide
   Show/Hide
C32H39N7O3
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0406563
N-[3-[4-[4-[1-(3,3-dimethylbutanoyl)piperidin-4-yl]oxy-3-methylanilino]quinazolin-6-yl]prop-2-ynyl]-2-methoxyacetamide
   Show/Hide
C32H39N5O4
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0514244
N-(2,6-difluorophenyl)-4-[2-methyl-4-[(6-morpholin-4-ylpyrido[3,4-d]pyrimidin-4-yl)amino]phenoxy]piperidine-1-carboxamide
   Show/Hide
C30H31F2N7O3
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0384975
1-(4-(4-(6-(2-methoxyethoxy)quinazolin-4-ylamino)-2-methylphenoxy)piperidin-1-yl)-3,3-dimethylbutan-1-one
   Show/Hide
C29H38N4O4
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0406565
N-(2,6-difluorophenyl)-4-[4-[[6-(dimethylamino)pyrido[3,4-d]pyrimidin-4-yl]amino]-2-methylphenoxy]piperidine-1-carboxamide
   Show/Hide
C28H29F2N7O2
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0384972
4-(4-(6-(3-(2-methoxyacetamido)prop-1-ynyl)quinazolin-4-ylamino)-2-methylphenoxy)-N-neopentylbenzamide
   Show/Hide
C33H35N5O4
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0049369
4-(2-methyl-4-(6-morpholinopyrido[3,4-d]pyrimidin-4-ylamino)phenoxy)-N-neopentylbenzamide
   Show/Hide
C30H34N6O3
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0496927
cyclopentyl-[4-[4-[[6-(2-methoxyethoxy)quinazolin-4-yl]amino]-2-methylphenoxy]piperidin-1-yl]methanone
   Show/Hide
C29H36N4O4
 1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
CP0529791
N-tert-butyl-3-[4-[[6-[3-[(2-methoxyacetyl)amino]prop-1-ynyl]quinazolin-4-yl]amino]-2-methylphenoxy]benzamide
   Show/Hide
C32H33N5O4
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0406561
cyclopentyl-[4-[2-methyl-4-[(6-morpholin-4-ylpyrido[3,4-d]pyrimidin-4-yl)amino]phenoxy]piperidin-1-yl]methanone
   Show/Hide
C29H36N6O3
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0439664
N-(2,6-difluorophenyl)-4-[4-[[6-(2-methoxyethoxy)quinazolin-4-yl]amino]-2-methylphenoxy]piperidine-1-carboxamide
   Show/Hide
C30H31F2N5O4
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0486207
3,3-dimethyl-1-[4-[2-methyl-4-[[6-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]phenoxy]piperidin-1-yl]butan-1-one
   Show/Hide
C33H45N5O4
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0486209
N-[3-[4-[4-[1-(cyclobutanecarbonyl)piperidin-4-yl]oxy-3-methylanilino]quinazolin-6-yl]prop-2-ynyl]-2-methoxyacetamide
   Show/Hide
C31H35N5O4
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0467956
N-(2,6-difluorophenyl)-4-[2-methyl-4-[[6-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]phenoxy]piperidine-1-carboxamide
   Show/Hide
C34H38F2N6O4
 1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
CP0435598
N-(2,6-difluorophenyl)-4-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylphenoxy]piperidine-1-carboxamide
   Show/Hide
C29H29F2N5O4
 1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
CP0384979
N-[3-[4-[4-[1-(3-chlorobenzoyl)piperidin-4-yl]oxy-3-methylanilino]quinazolin-6-yl]prop-2-ynyl]-2-methoxyacetamide
   Show/Hide
C33H32ClN5O4
 1
1
IC50 = 75 nM
   TI
   LI
   LO
   TS
CP0496928
1-(4-(4-(6,7-dimethoxyquinazolin-4-ylamino)-2-methylphenoxy)piperidin-1-yl)-3,3-dimethylbutan-1-one
   Show/Hide
C28H36N4O4
 1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0445841
3-(4-(6-(3-(2-methoxyacetamido)prop-1-ynyl)quinazolin-4-ylamino)-2-methylphenoxy)-N-neopentylbenzamide
   Show/Hide
C33H35N5O4
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0541868
N-cyclobutyl-3-[4-[[6-[3-[(2-methoxyacetyl)amino]prop-1-ynyl]quinazolin-4-yl]amino]-2-methylphenoxy]benzamide
   Show/Hide
C32H31N5O4
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0276148
4-N-(3-bromophenyl)-6-N-methylquinazoline-4,6-diamine
   Show/Hide
C15H13BrN4
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0445814
N-(2,6-difluorophenyl)-4-[2-methyl-4-[[6-(methylamino)pyrido[3,4-d]pyrimidin-4-yl]amino]phenoxy]piperidine-1-carboxamide
   Show/Hide
C27H27F2N7O2
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0406562
N-(2,6-difluorophenyl)-4-[4-[[6-[3-[(2-methoxyacetyl)amino]prop-1-ynyl]quinazolin-4-yl]amino]-2-methylphenoxy]piperidine-1-carboxamide
   Show/Hide
C33H32F2N6O4
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0486211
N-(2,6-difluorophenyl)-4-[4-[(6-methoxyquinazolin-4-yl)amino]-2-methylphenoxy]piperidine-1-carboxamide
   Show/Hide
C28H27F2N5O3
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0406564
4-(4-(6,7-dimethoxyquinazolin-4-ylamino)-2-methylphenoxy)-N-neopentylbenzamide
   Show/Hide
C29H32N4O4
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0063852
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({5-[(4-ethylpiperazin-1-yl)carbonyl]-3-methyl-1H-pyrrol-2-yl}methylidene)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
   Show/Hide
C25H25ClFN7O2
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0217755
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
   Show/Hide
C24H23ClFN7O2
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0357546
5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-methyl-1H-pyrrole-2-carboxamide
   Show/Hide
C25H27ClFN7O2
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0201108
5-{[(5Z)-4-[(3-ethynylphenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-4-methyl-N-[2-(morpholin-4-yl)ethyl]-1H-pyrrole-2-carboxamide
   Show/Hide
C27H27N7O3
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0204735
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({5-[(3,5-dimethylpiperazin-1-yl)carbonyl]-3-methyl-1H-pyrrol-2-yl}methylidene)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
   Show/Hide
C25H25ClFN7O2
 1
1
IC50 = 510 nM
   TI
   LI
   LO
   TS
CP0467957
1-(4-(4-(6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino)-2-methylphenoxy)piperidin-1-yl)-3,3-dimethylbutan-1-one
   Show/Hide
C32H44N4O6
 1
1
IC50 = 530 nM
   TI
   LI
   LO
   TS
CP0486205
(4-(4-(6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino)-2-methylphenoxy)piperidin-1-yl)(cyclopentyl)methanone
   Show/Hide
C32H42N4O6
 1
1
IC50 = 530 nM
   TI
   LI
   LO
   TS
CP0138773
4-Anilinoquinazoline deriv. 45
   Show/Hide
C14H11BrN4
 1
1
IC50 = 670 nM
   TI
   LI
   LO
   TS
CP0293174
1-(2-chloroethyl)-1-nitroso-3-methyl-3-{[4-(3-chloro-phenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C18H16Cl2N6O2
 1
1
IC50 = 680 nM
   TI
   LI
   LO
   TS
CP0435603
4-(4-(6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino)-2-methylphenoxy)-N-(2,6-difluorophenyl)piperidine-1-carboxamide
   Show/Hide
C33H37F2N5O6
 1
1
IC50 = 840 nM
   TI
   LI
   LO
   TS
CP0328172
4-[(3-chlorophenyl)amino]-6-(methylamino)quinazoline
   Show/Hide
C15H13ClN4
 1
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
CP0343594
1-(2-chloroethyl)-1-nitroso-3-{[4-(3-bromophenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C17H14BrClN6O2
 1
1
IC50 = 1150 nM
   TI
   LI
   LO
   TS
CP0084269
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-pyrrol-2-yl]methylidene}-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
   Show/Hide
C23H20ClFN6O3
 1
1
IC50 = 1210 nM
   TI
   LI
   LO
   TS
CP0088175
5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-4-methyl-N-[2-(morpholin-4-yl)ethyl]-1H-pyrrole-2-carboxamide
   Show/Hide
C25H25ClFN7O3
 1
1
IC50 = 1240 nM
   TI
   LI
   LO
   TS
CP0197387
1-(2-chloroethyl)-3-{[4-(3-chlorophenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C17H15Cl2N5O
 1
1
IC50 = 1350 nM
   TI
   LI
   LO
   TS
CP0041166
5-{[(5Z)-4-[(1-benzyl-1H-indol-5-yl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-4-methyl-N-[2-(morpholin-4-yl)ethyl]-1H-pyrrole-2-carboxamide
   Show/Hide
C34H34N8O3
 1
1
IC50 = 1560 nM
   TI
   LI
   LO
   TS
CP0455094
1-(2-chloroethyl)-3-{[4-(3-bromophenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C17H15BrClN5O
 1
1
IC50 = 1770 nM
   TI
   LI
   LO
   TS
CP0532346
4-[(3-methylphenyl)amino]-6-(methylamino)quinazoline
   Show/Hide
C16H16N4
 1
1
IC50 = 2070 nM
   TI
   LI
   LO
   TS
CP0520193
1-(2-chloroethyl)-3-{[4-(3-methylphenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C18H18ClN5O
 1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0217745
(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
   Show/Hide
C19H15ClFN5O
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0255898
(5Z)-4-(2,3-dihydro-1H-inden-5-ylamino)-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-pyrrol-2-yl]methylidene}-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
   Show/Hide
C26H26N6O3
 1
1
IC50 = 2780 nM
   TI
   LI
   LO
   TS
CP0384978
2-methoxy-N-[3-(4-{3-methyl-4-[1-(tetrahydro-furan-2-carbonyl)-piperidin-4-yloxy]-phenylamino}-quinazolin-6-yl)-prop-2-ynyl]-acetamide
   Show/Hide
C31H35N5O5
 1
1
IC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0190700
1-(2-chloroethyl)-1-nitroso-3-methyl-3-{[4-(3-bromophenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C18H16BrClN6O2
 1
1
IC50 = 3060 nM
   TI
   LI
   LO
   TS
CP0190702
Anilinoquinazoline, 4c
   Show/Hide
C14H11ClN4
 1
1
IC50 = 3290 nM
   TI
   LI
   LO
   TS
CP0341988
1-(2-Chloroethyl)-1-nitroso-3-{[4-(3-chlorophenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C17H14Cl2N6O2
 1
1
IC50 = 5400 nM
   TI
   LI
   LO
   TS
CP0048287
Anilinoquinazoline, 4a
   Show/Hide
C15H14N4
 1
1
IC50 = 6390 nM
   TI
   LI
   LO
   TS
CP0340557
1-(2-chloroethyl)-1-nitroso-3-methyl-3-{[4-(3-methylphenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C19H19ClN6O2
 1
1
IC50 = 6880 nM
   TI
   LI
   LO
   TS
CP0341989
3-(2-chloroethyl)-1-methyl-1-{[4-(3-bromophenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C18H17BrClN5O
 1
1
IC50 = 11080 nM
   TI
   LI
   LO
   TS
CP0293175
3-(2-chloroethyl)-1-methyl-1-{[4-(3-methylphenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C19H20ClN5O
 1
1
IC50 = 11800 nM
   TI
   LI
   LO
   TS
CP0503940
1-(2-Chloroethyl)-1-nitroso-3-{[4-(3-methylphenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C18H17ClN6O2
 1
1
IC50 = 12180 nM
   TI
   LI
   LO
   TS
CP0190701
3-(2-chloroethyl)-1-methyl-1-{[4-(3-chlorophenyl)amino]quinazolin-6-yl}urea
   Show/Hide
C18H17Cl2N5O
 1
1
IC50 = 23030 nM
   TI
   LI
   LO
   TS
CP0358290
5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl}-4-methyl-1H-pyrrole-2-carboxylic acid
   Show/Hide
C19H13ClFN5O3
 1
1
IC50 = 49300 nM
   TI
   LI
   LO
   TS