Brief Information of the Cell Line and Protein
Cell Line ID: CL000034 , Caco-2
 Cell Line Info 
Synonyms
CaCo-2
CACO-2
Caco 2
CACO 2
CACO2
CaCo2
CaCO2
Caco2
Caco-2/ATCC
Caco-II
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0025
Protein ID: PT02536 , Diacylglycerol O-acyltransferase 1
 Protein Info 
Gene Name DGAT1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID O75907
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000034
 Cell Line Info 
 Protein ID: PT02536
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0388551
 Compound Info 
ethyl 6-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate
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C29H35N5O4
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
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CP0411910
 Compound Info 
ethyl 6-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate
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C30H35N5O4
  1
1
IC50 < 30 nM
 Bioactivity Info 
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CP0435339
 Compound Info 
ethyl 6-(3-cyclohexyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate
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C31H37N5O4
  1
1
IC50 = 31 nM
 Bioactivity Info 
   TI
   LI
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CP0412013
 Compound Info 
ethyl 2-morpholin-4-yl-4-phenyl-6-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate
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C28H33N5O4
  1
1
IC50 = 51 nM
 Bioactivity Info 
   TI
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CP0435340
 Compound Info 
ethyl 6-(3-butyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate
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C29H35N5O4
  1
1
IC50 = 69 nM
 Bioactivity Info 
   TI
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   LO
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CP0388552
 Compound Info 
ethyl 2-morpholin-4-yl-4-phenyl-7-propyl-6-(3-pyrrolidin-1-yl-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazine-5-carboxylate
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C29H34N6O4
  1
1
IC50 = 100 nM
 Bioactivity Info 
   TI
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CP0388555
 Compound Info 
ethyl 2-morpholin-4-yl-4-phenyl-6-(3-phenyl-1,2,4-oxadiazol-5-yl)-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate
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C31H31N5O4
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0388556
 Compound Info 
ethyl 7-(2-hydroxyethyl)-6-[3-(2-hydroxyethyl)-1,2,4-oxadiazol-5-yl]-2-morpholin-4-yl-4-phenylpyrrolo[1,2-b]pyridazine-5-carboxylate
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C26H29N5O6
  1
1
IC50 = 260 nM
 Bioactivity Info 
   TI
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   LO
   TS