Brief Information of the Cell Line and Protein
Cell Line ID: CL000031 , MDCK
Synonyms
MDCK (NBL-2)
MDCK(NBL-2)
NBL-2
Madin-Darby Canine Kidney
Madin Darby Canine Kidney
Category Spontaneously immortalized cell line
Organism
Canis lupus familiaris (Dog)
Cellosaurus ID
CVCL_0422
Protein ID: PT02681 , Neuraminidase
Organism Influenza A virus (strain A/Wilson-Smith/1933 H1N1), Influenza A virus (strain A/WS/1933 H1N1)
Protein Classification Enzyme
Uniprot ID P03470
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000031  Protein ID: PT02681
 
Compound ID Compound Name Compound Formula
CP0036726
(2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C12H20N4O7
 1
1
IC50 = 0.8 nM
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CP0571266
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-(4-cyclohexyltriazol-1-yl)acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H33N7O8
 1
1
IC50 = 2.3 nM
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CP0504047
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(2-methoxyphenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C23H29N7O9
 1
1
IC50 = 8 nM
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CP0463870
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(3-chlorophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H26ClN7O8
 1
1
IC50 = 9 nM
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CP0571265
(3R,4S)-3-acetamido-4-[[amino-[[2-(4-phenyltriazol-1-yl)acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H27N7O8
 1
1
IC50 = 9.9 nM
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CP0571267
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(3-aminophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H28N8O8
 1
1
IC50 = 10 nM
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CP0508099
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(2-aminophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H28N8O8
 1
1
IC50 = 12 nM
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CP0534780
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-aminophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H28N8O8
 1
1
IC50 = 12 nM
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CP0565266
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-methoxyphenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C23H29N7O9
 1
1
IC50 = 12 nM
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CP0519279
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(3-ethoxycarbonylphenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C25H31N7O10
 1
1
IC50 = 13 nM
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CP0463871
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(3-fluorophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H26FN7O8
 1
1
IC50 = 14 nM
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CP0566702
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-methylphenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C23H29N7O8
 1
1
IC50 = 14 nM
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CP0475753
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-chlorophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H26ClN7O8
 1
1
IC50 = 15 nM
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CP0519458
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(cyclohexen-1-yl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H31N7O8
 1
1
IC50 = 15 nM
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CP0563238
(2R,3R,4S)-3-acetamido-4-[[amino-[(2-naphthalen-2-ylsulfanylacetyl)amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C24H28N4O8S
 1
1
IC50 = 20 nM
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CP0571268
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-fluorophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H26FN7O8
 1
1
IC50 = 29 nM
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CP0534781
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(6-methoxynaphthalen-2-yl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C27H31N7O9
 1
1
IC50 = 31 nM
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CP0561441
(3R,4S)-3-acetamido-4-[[amino-[3-(4-phenyltriazol-1-yl)propanoylamino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C23H29N7O8
 1
1
IC50 = 146.2 nM
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CP0534779
(3R,4S)-3-acetamido-4-[[amino-[5-(4-phenyltriazol-1-yl)pentanoylamino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C25H33N7O8
 1
1
IC50 = 168.6 nM
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CP0452050
(3R,4S)-3-acetamido-4-[[amino-[4-(4-phenyltriazol-1-yl)butanoylamino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C24H31N7O8
 1
1
IC50 = 238.3 nM
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