General Information of the Protein
Protein ID
PT02681
Protein Name
Neuraminidase
Sequence
MNPNQKIITIGSICMVVGIISLILQIGNIISIWISHSIQTGNQNHTGICNQGIITYNVVAGQDSTSVILTGNSSLCPIRGWAIHSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECTCVNGSCFTIMTDGPSNGLASYKIFKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPKDGPGSCGPVSADGANGVKGFSYRYGNGVWIGRTKSDSSRHGFEMIWDPNGWTETDSRFSVRQDVVAMTDRSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPEEETIWTSGSIISFCGVNSDTVDWSWPDGAELPFTIDK
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Organism
Influenza A virus (strain A/Wilson-Smith/1933 H1N1), Influenza A virus (strain A/WS/1933 H1N1)
Protein Classification
Enzyme
>
Hydrolase
Function
Unlike other strains, A/WSN/33 neuraminidase binds and activates plasminogen into plasmin in the vicinity of HA so that activated plasmin cleaves HA rendering the virus infectious.
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Uniprot ID
Primary ID:
P03470

Secondarily ID:
Q67215
Q67216
Q67217
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Subcellular Location
Virion membrane
Host apical cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000031 , MDCK
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0036726
 Compound Info 
(2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C12H20N4O7
  1
1
IC50 = 0.8 nM
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CP0571266
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-(4-cyclohexyltriazol-1-yl)acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H33N7O8
  1
1
IC50 = 2.3 nM
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CP0504047
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(2-methoxyphenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C23H29N7O9
  1
1
IC50 = 8 nM
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CP0463870
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(3-chlorophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H26ClN7O8
  1
1
IC50 = 9 nM
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CP0571265
 Compound Info 
(3R,4S)-3-acetamido-4-[[amino-[[2-(4-phenyltriazol-1-yl)acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H27N7O8
  1
1
IC50 = 9.9 nM
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CP0571267
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(3-aminophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H28N8O8
  1
1
IC50 = 10 nM
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CP0508099
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(2-aminophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H28N8O8
  1
1
IC50 = 12 nM
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CP0534780
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-aminophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H28N8O8
  1
1
IC50 = 12 nM
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CP0565266
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-methoxyphenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C23H29N7O9
  1
1
IC50 = 12 nM
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CP0519279
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(3-ethoxycarbonylphenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C25H31N7O10
  1
1
IC50 = 13 nM
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CP0463871
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(3-fluorophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H26FN7O8
  1
1
IC50 = 14 nM
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CP0566702
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-methylphenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C23H29N7O8
  1
1
IC50 = 14 nM
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CP0475753
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-chlorophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H26ClN7O8
  1
1
IC50 = 15 nM
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CP0519458
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(cyclohexen-1-yl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H31N7O8
  1
1
IC50 = 15 nM
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CP0563238
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[(2-naphthalen-2-ylsulfanylacetyl)amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C24H28N4O8S
  1
1
IC50 = 20 nM
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CP0571268
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(4-fluorophenyl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C22H26FN7O8
  1
1
IC50 = 29 nM
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CP0534781
 Compound Info 
(2R,3R,4S)-3-acetamido-4-[[amino-[[2-[4-(6-methoxynaphthalen-2-yl)triazol-1-yl]acetyl]amino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C27H31N7O9
  1
1
IC50 = 31 nM
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CP0561441
 Compound Info 
(3R,4S)-3-acetamido-4-[[amino-[3-(4-phenyltriazol-1-yl)propanoylamino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C23H29N7O8
  1
1
IC50 = 146.2 nM
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CP0534779
 Compound Info 
(3R,4S)-3-acetamido-4-[[amino-[5-(4-phenyltriazol-1-yl)pentanoylamino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C25H33N7O8
  1
1
IC50 = 168.6 nM
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CP0452050
 Compound Info 
(3R,4S)-3-acetamido-4-[[amino-[4-(4-phenyltriazol-1-yl)butanoylamino]methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C24H31N7O8
  1
1
IC50 = 238.3 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0178991
 Compound Info 
(1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-[3-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]propylcarbamoyloxy]cyclopentane-1-carboxylic acid
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C28H42N6O8
  1
1 IC50 = 0.44 nM
CP0078933
 Compound Info 
(-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-{[amino(imino)methyl]amino}-2-hydroxycyclopentanecarboxylic Acid
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C15H28N4O4
  1
1 IC50 = 0.48 nM
CP0036726
 Compound Info 
(2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C12H20N4O7
  4
1 IC50 = 1 nM
2 IC50 = 1.6 nM
3 IC50 = 2.4 nM
4 IC50 = 2.9 nM
CP0257627
 Compound Info 
(1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-[3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropylcarbamoyloxy]cyclopentane-1-carboxylic acid
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C28H41N5O9
  1
1 IC50 = 1.05 nM
Clinical Information about the Protein
Target 1 ( Influenza Neuraminidase (Influ NA) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Influenza virus infection [ICD-11: 1E30-1E32]
Approved Drug(s) 3 Approved Drugs  3
1 Oseltamivir
 Drug Info 
Approved
Influenza virus infection
2 Peramivir
 Drug Info 
Approved
Influenza virus infection
3 Zanamivir
 Drug Info 
Approved
Influenza virus infection
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 CS-8958
 Drug Info 
Phase 3
Influenza virus infection
Discontinued Drug(s) 1 Discontinued Drug  1
1 BCX-140
 Drug Info 
Terminated
Influenza virus infection
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01603 Neuraminidase Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
 Protein Info