Brief Information of the Cell Line and Protein
Cell Line ID: CL000028 , PC-12
Synonyms
PC 12
PC12
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_S979
Protein ID: PT01020 , Beta-secretase 1
Gene Name BACE1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P56817
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000028  Protein ID: PT01020
 
Compound ID Compound Name Compound Formula
CP0252084
(1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)-propyl]-5-methyl -N,N-dipropylisophthalamide
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C32H38F2IN3O3
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0471947
4-(2-{5-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoylamino}-propionylamino)-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid(Ac-Val-Met-Hydroxyethylene-Ala-Glu-Phe-COOH)
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C41H66N6O11S
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0139079
(1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-methoxybenzylamino)-propyl]-5-methyl-N,N-dipropylisophthalamide
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C33H41F2N3O4
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0130120
(4S)-4-[[(2S)-2-[[(2S)-2-[[(3S,4S)-4-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-carboxy-2-[[(2S)-4-carboxy-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]butanoyl]amino]butanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acid
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C73H118N16O27
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0846898
4-{2-[2-(4-{2-[2-(2-Amino-4-carboxy-butyrylamino)-3-methyl-butyrylamino]-3-carbamoyl-propionylamino}-3-hydroxy-6-methyl-heptanoylamino)-3-methyl-butyrylamino]-propionylamino}-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid (NH2-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-COOH)
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C44H69N9O15
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0378523
(1S,2R)-N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(S)-(1-isobutylcarbamoyl-ethylamino)-propyl]-5-methyl-N,N-dipropylisophthalamide
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C32H46F2N4O4
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0374186
(1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(benzylamino)-propyl]-5-methyl-N,N-dipropylisophthalamide
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C32H39F2N3O3
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0453716
3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[(1S)-1-[(2-methylpropyl)carbamoyl]ethyl]amino}butan-2-yl]-1-N,1-N-dipropylbenzene-1,3-dicarboxamide
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C31H44F2N4O4
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0446343
(1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(1-isobutylcarbamoyl-1-methyl-ethylamino)-propyl]-5-methyl-N,N-dipropylisophthalamide
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C33H48F2N4O4
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0535062
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-propionylamino]-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid(N-acetyl-Val-Met-Sta-Val-Ala-Glu-Phe-COOH)
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C42H67N7O12S
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0507170
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-3-carbamoyl-propionylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-propionylamino]-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid(N-acetyl-Val-Asn-Sta-Val-Ala-Glu-Phe-COOH)
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C41H64N8O13
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0528783
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-5-phenyl-pentanoylamino}-3-methyl-butyrylamino)-propionylamino]-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid(Ac-Val-Met-AHPPA-Ala-Glu-Phe-COOH)
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C45H65N7O12S
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0942211
NH2-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta(S-OH)-A-A-E-F
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C71H114N16O27
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0372069
(1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(R)-(1-isobutylcarbamoyl-ethylamino)-propyl]-N,N-dipropyl-isophthalamide
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C31H44F2N4O4
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0424646
2-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-propionylamino]-pentanedioic acid(Ac-Val-Met-Sta-Val-Ala-Glu-COOH)
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C33H58N6O11S
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0948680
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-propionylamino]-4-(1-carboxy-ethylcarbamoyl)-butyric acid (Ac-Val-Met-Sta-Val-Ala-Glu-Ala-COOH)
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C36H63N7O12S
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0919021
2-{2-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-propionylamino]-propionylamino}-3-phenyl-propionic acid (Ac-Val-Met-Sta-Val-Ala-Ala-Phe-COOH)
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C40H65N7O10S
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0874928
4-{2-[2-(4-{2-[2-(2-Amino-4-carboxy-butyrylamino)-propionylamino]-3-carbamoyl-propionylamino}-3-hydroxy-6-methyl-heptanoylamino)-3-methyl-butyrylamino]-propionylamino}-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid (NH2-Glu-Ala-Asn-Sta-Val-Ala-Glu-Phe-COOH)
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C42H65N9O15
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0492235
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid
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C91H150N24O32
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0496638
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-propionylamino)-propionylamino]-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid(Ac-Val-Met-Sta-Ala-Ala-Glu-Phe-COOH)
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C40H63N7O12S
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0559478
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-5-cyclohexyl-3-hydroxy-pentanoylamino}-3-methyl-butyrylamino)-propionylamino]-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid(Ac-Val-Met-ACHPA-Ala-Glu-Phe-COOH)
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C45H71N7O12S
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0919438
4-[2-(2-{4-[2-(2-Amino-3-methyl-butyrylamino)-3-carbamoyl-propionylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-propionylamino]-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid (NH2-Val-Asn-Sta-Val-Ala-Glu-Phe-COOH)
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C39H62N8O12
 1
1
IC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0494995
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-phenyl-propionylamino)-propionylamino]-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid(Ac-Val-Met-Sta-Phe-Ala-Glu-Phe-COOH)
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C46H67N7O12S
 1
1
IC50 = 15000 nM
   TI
   LI
   LO
   TS
CP0881014
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3,3-dimethyl-butyrylamino)-propionylamino]-4-(1-carboxy-ethylcarbamoyl)-butyric acid (Ac-Val-Met-Sta-tleu-Ala-Glu-Ala-COOH)
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C37H65N7O12S
 1
1
IC50 = 20000 nM
   TI
   LI
   LO
   TS
CP0507725
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid
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C95H150N24O32
 1
1
IC50 = 40000 nM
   TI
   LI
   LO
   TS
CP0510920
(4S)-4-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid
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C92H153N25O32
 1
1
IC50 = 40000 nM
   TI
   LI
   LO
   TS
CP0941552
NH2-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta(S-OH)-D-A-E-F
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C72H114N16O29
 1
1
IC50 = 40000 nM
   TI
   LI
   LO
   TS
CP0504937
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid
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C92H152N24O32
 1
1
IC50 = 45000 nM
   TI
   LI
   LO
   TS
CP0853928
NH2-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta(S-OH)-D-A-E-F-R
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C78H126N20O30
 1
1
IC50 = 60000 nM
   TI
   LI
   LO
   TS
CP0461801
2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-propionic acid(Ac-Val-Met-Sta-Val-Ala-COOH)
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C28H51N5O8S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0497729
2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyric acid(Ac-Val-Met-Sta-Val-COOH)
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C25H46N4O7S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0507750
(4S)-4-[[(2S)-2-[[(2S,3S)-2-[[4-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acid
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C41H65N7O13S
 1
1
IC50 = 100000 nM
   TI
   LI
   LO
   TS
CP0881068
4-[2-(2-{4-[2-(2-Acetylamino-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-carboxy-propionylamino)-propionylamino]-4-(1-carboxy-ethylcarbamoyl)-butyric acid (Ac-Val-Met-Sta-Asp-Ala-Glu-Ala-COOH)
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C35H59N7O14S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS