General Information of the Compound
Compound ID
CP0446343
Compound Name
(1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(1-isobutylcarbamoyl-1-methyl-ethylamino)-propyl]-5-methyl-N,N-dipropylisophthalamide
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Structure
Formula
C33H48F2N4O4
Molecular Weight
602.767
Canonical SMILES
CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNC(C)(C)C(=O)NCC(C)C
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InChI
InChI=1S/C33H48F2N4O4/c1-8-10-39(11-9-2)31(42)25-13-22(5)12-24(17-25)30(41)38-28(16-23-14-26(34)18-27(35)15-23)29(40)20-37-33(6,7)32(43)36-19-21(3)4/h12-15,17-18,21,28-29,37,40H,8-11,16,19-20H2,1-7H3,(H,36,43)(H,38,41)/t28-,29+/m0/s1
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InChIKey
USWOYPKVOXJJPM-URLMMPGGSA-N
Physicochemical Property
logP
4.37782
Rotatable Bonds
16
Heavy Atom Count
43
Polar Areas
110.77
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16109351
SID: 24756119
ChEMBL ID
CHEMBL265862
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000028 PC-12 Homo sapiens (Human)  1
1
IC50 = 200 nM
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