Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT06248 , Transient receptor potential cation channel subfamily M member 5
Gene Name TRPM5
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID Q9NZQ8
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT06248
 
Compound ID Compound Name Compound Formula
CP0548251
5-chloro-N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-6-amine
   Show/Hide
C11H7Cl2N3S2
 1
1
EC50 = 7.943 nM
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CP0562058
5-chloro-N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1,2-benzothiazol-6-amine
   Show/Hide
C12H10Cl2N4S
 1
1
EC50 = 11.22 nM
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CP0571559
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-5-methyl-1,2-benzothiazol-6-amine
   Show/Hide
C12H10ClN3S2
 1
1
EC50 = 17.78 nM
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CP0485498
6-chloro-N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C11H7Cl2N3S2
 1
1
EC50 = 24.55 nM
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CP0576552
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-5-fluoro-1,2-benzothiazol-6-amine
   Show/Hide
C11H7ClFN3S2
 1
1
EC50 = 28.84 nM
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CP0568461
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-5-methyl-1,2-benzothiazol-6-amine
   Show/Hide
C13H13ClN4S
 1
1
EC50 = 38.02 nM
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CP0569676
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-6-methyl-1,2-benzothiazol-5-amine
   Show/Hide
C12H10ClN3S2
 1
1
EC50 = 38.9 nM
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CP0538206
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-6-amine
   Show/Hide
C11H8ClN3S2
 1
1
EC50 = 43.65 nM
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CP0568271
[(1S,3S)-6,7-dichloro-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H15Cl2NO
 1
1
EC50 = 50.12 nM
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CP0579190
[(1S,3S)-6-chloro-1-(3-chloro-5-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H14Cl2FNO
 1
1
EC50 = 63.1 nM
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CP0479409
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-N-methyl-1,2-benzothiazol-6-amine
   Show/Hide
C13H13ClN4S
 1
1
EC50 = 85.11 nM
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CP0492478
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C11H8ClN3S2
 1
1
EC50 = 89.13 nM
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CP0576549
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-6-fluoro-1,2-benzothiazol-5-amine
   Show/Hide
C11H7ClFN3S2
 1
1
EC50 = 97.72 nM
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CP0550111
[(1S,3S)-7-chloro-1-(3-chloro-5-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H14Cl2FNO
 1
1
EC50 = 100 nM
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CP0563561
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-5-fluoro-1,2-benzothiazol-6-amine
   Show/Hide
C12H10ClFN4S
 1
1
EC50 = 102.33 nM
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CP0568382
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-N-methyl-1,2-benzothiazol-5-amine
   Show/Hide
C13H13ClN4S
 1
1
EC50 = 158.49 nM
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CP0576546
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-N-(cyclopropylmethyl)-1,2-benzothiazol-5-amine
   Show/Hide
C16H17ClN4S
 1
1
EC50 = 158.49 nM
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CP0546494
[(1S,3S)-7-chloro-1-(3,5-difluorophenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H14ClF2NO
 1
1
EC50 = 199.53 nM
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CP0569411
[(1S,3S)-7-chloro-1-(3,5-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H14Cl3NO
 1
1
EC50 = 199.53 nM
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CP0575570
3-[(1S,3S)-6-chloro-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-fluorobenzonitrile
   Show/Hide
C17H14ClFN2O
 1
1
EC50 = 251.19 nM
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CP0568462
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1,2-benzothiazol-6-amine
   Show/Hide
C12H11ClN4S
 1
1
EC50 = 295.12 nM
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CP0559555
5-chloro-N-[(5-chloro-1-methylimidazol-2-yl)methyl]-N-methyl-1,2-benzothiazol-6-amine
   Show/Hide
C13H12Cl2N4S
 1
1
EC50 = 309.03 nM
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CP0543308
[(1S,3S)-7-chloro-1-(3-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H15ClFNO
 1
1
EC50 = 316.23 nM
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CP0546491
[(1S,3S)-6-chloro-7-fluoro-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H15ClFNO
 1
1
EC50 = 316.23 nM
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CP0538205
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C12H11ClN4S
 1
1
EC50 = 331.13 nM
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CP0568384
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-N-methyl-1,2-benzothiazol-5-amine
   Show/Hide
C12H10ClN3S2
 1
1
EC50 = 446.68 nM
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CP0568379
N-[(5-bromo-1-methylimidazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C12H11BrN4S
 1
1
EC50 = 457.09 nM
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CP0492474
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-N-ethyl-1,2-benzothiazol-5-amine
   Show/Hide
C14H15ClN4S
 1
1
EC50 = 467.74 nM
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CP0563560
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-[1,2]thiazolo[5,4-c]pyridin-5-amine
   Show/Hide
C10H7ClN4S2
 1
1
EC50 = 467.74 nM
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CP0568381
N-[[5-(trifluoromethyl)-1,3-thiazol-2-yl]methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C12H8F3N3S2
 1
1
EC50 = 489.78 nM
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CP0543274
[(1S,3S)-6-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H16ClNO
 1
1
EC50 = 501.19 nM
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CP0545138
[(1S,3S)-7-chloro-1-(3-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H15Cl2NO
 1
1
EC50 = 501.19 nM
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CP0576545
N-[(5-methyl-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C12H11N3S2
 1
1
EC50 = 575.44 nM
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CP0546488
(1E)-1-(3-methyl-1,3-benzothiazol-2-ylidene)-3-prop-2-enylthiourea
   Show/Hide
C12H13N3S2
 1
1
EC50 = 630.96 nM
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CP0568272
[(1S,3S)-7-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H16ClNO
 1
1
EC50 = 794.33 nM
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CP0569675
5-[(5-chloro-1,3-thiazol-2-yl)methoxy]-1,2-benzothiazole
   Show/Hide
C11H7ClN2OS2
 1
1
EC50 = 831.76 nM
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CP0562269
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-4-fluoro-1,2-benzothiazol-5-amine
   Show/Hide
C11H7ClFN3S2
 1
1
EC50 = 933.25 nM
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CP0568078
[(1S,3S)-7-chloro-1-(4-chloro-3-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C17H17Cl2NO
 1
1
EC50 = 1000 nM
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CP0569944
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-[1,2]thiazolo[4,5-b]pyridin-5-amine
   Show/Hide
C10H7ClN4S2
 1
1
EC50 = 1174.9 nM
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CP0543307
[(1S,3S)-5-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H16ClNO
 1
1
EC50 = 1258.93 nM
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CP0568386
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-7-fluoro-1,2-benzothiazol-5-amine
   Show/Hide
C11H7ClFN3S2
 1
1
EC50 = 1380.38 nM
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CP0569152
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-7-amine
   Show/Hide
C11H8ClN3S2
 1
1
EC50 = 1445.44 nM
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CP0569943
4-chloro-N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C11H7Cl2N3S2
 1
1
EC50 = 1584.89 nM
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CP0578778
[(1R,3S)-6-chloro-1-(2-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C16H15Cl2NO
 1
1
EC50 = 1584.89 nM
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CP0485500
6-chloro-N-[(5-chloro-1,3-thiazol-2-yl)methyl]-N-methyl-1,2-benzothiazol-5-amine
   Show/Hide
C12H9Cl2N3S2
 1
1
EC50 = 1621.81 nM
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CP0485499
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-4-methyl-1,2-benzothiazol-5-amine
   Show/Hide
C12H10ClN3S2
 1
1
EC50 = 1737.8 nM
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CP0578503
[(1S,3S)-6-chloro-1-(3-chloro-5-fluorophenyl)-1,2,3,4-tetrahydro-2,7-naphthyridin-3-yl]methanol
   Show/Hide
C15H13Cl2FN2O
 1
1
EC50 = 1995.26 nM
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CP0571553
4-chloro-N-[(1-methylimidazol-2-yl)methyl]-2-(3,3,3-trifluoropropoxy)aniline
   Show/Hide
C14H15ClF3N3O
 1
1
EC50 = 2511.89 nM
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CP0562075
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-6-fluoro-N-methyl-1,2-benzothiazol-5-amine
   Show/Hide
C12H9ClFN3S2
 1
1
EC50 = 2818.38 nM
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CP0492470
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1,2-benzoxazol-5-amine
   Show/Hide
C12H11ClN4O
 1
1
EC50 = 3019.95 nM
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CP0568077
[(6S,8S)-3-chloro-8-(3-chloro-5-fluorophenyl)-5,6,7,8-tetrahydro-1,7-naphthyridin-6-yl]methanol
   Show/Hide
C15H13Cl2FN2O
 1
1
EC50 = 3162.28 nM
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CP0491411
N-(1,3-thiazol-2-ylmethyl)-1,2-benzothiazol-5-amine
   Show/Hide
C11H9N3S2
 1
1
EC50 = 4677.35 nM
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CP0559592
4-chloro-N-[(5-chloro-1-methylimidazol-2-yl)methyl]-2-fluoroaniline
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C11H10Cl2FN3
 2
1
EC50 = 4677.35 nM
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2
EC50 = 6025.6 nM
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CP0569147
[1-[(5-chloro-1-methylimidazol-2-yl)methyl]-8-fluoro-3,4-dihydro-2H-quinolin-3-yl]methanol
   Show/Hide
C15H17ClFN3O
 1
1
EC50 = 5011.87 nM
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CP0492473
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-N-propan-2-yl-1,2-benzothiazol-5-amine
   Show/Hide
C15H17ClN4S
 1
1
EC50 = 5128.61 nM
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CP0563555
4-bromo-N-[(5-chloro-1-methylimidazol-2-yl)methyl]-N-ethylaniline
   Show/Hide
C13H15BrClN3
 1
1
EC50 = 5128.61 nM
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CP0569148
N-[(1-methylimidazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C12H12N4S
 1
1
EC50 = 5128.61 nM
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CP0492477
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-N,6-dimethyl-1,2-benzothiazol-5-amine
   Show/Hide
C13H12ClN3S2
 1
1
EC50 = 5248.07 nM
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CP0563556
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1-methylindazol-5-amine
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C13H14ClN5
 1
1
EC50 = 5248.07 nM
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CP0576528
N-[(5-chlorothiadiazol-4-yl)methyl]-1,2-benzothiazol-5-amine
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C10H7ClN4S2
 1
1
EC50 = 5248.07 nM
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CP0566509
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1H-indazol-5-amine
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C12H12ClN5
 1
1
EC50 = 6025.6 nM
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CP0568076
[(1S,3S)-7-chloro-1-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C17H18ClNO
 1
1
EC50 = 6309.57 nM
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CP0562057
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-[1,2]thiazolo[5,4-b]pyridin-5-amine
   Show/Hide
C10H7ClN4S2
 1
1
EC50 = 6606.93 nM
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CP0571557
N-[1-(5-chloro-1,3-thiazol-2-yl)ethyl]-1,2-benzothiazol-5-amine
   Show/Hide
C12H10ClN3S2
 1
1
EC50 = 7585.78 nM
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CP0568075
[(1R,3S)-7-chloro-1-pyridin-2-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C15H15ClN2O
 1
1
EC50 = 7943.28 nM
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CP0577378
(1S,3S)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-carbonitrile
   Show/Hide
C17H14ClFN2O
 1
1
EC50 = 7943.28 nM
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CP0546493
[(1S,3S)-6-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C17H19NO
 1
1
EC50 = 10000 nM
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CP0568073
[(1S,3S)-7-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C17H19NO
 1
1
EC50 = 10000 nM
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CP0571554
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1,3-benzothiazol-5-amine
   Show/Hide
C12H11ClN4S
 1
1
EC50 = 13489.63 nM
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CP0575568
(1S,3S)-7-chloro-3-(methoxymethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C17H18ClNO
 1
1
EC50 = 15848.93 nM
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CP0491421
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1,3-benzoxazol-5-amine
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C12H11ClN4O
 1
1
EC50 = 16218.1 nM
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CP0569149
N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C11H10N4S2
 1
1
EC50 = 19054.61 nM
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CP0569780
[(1R,3S)-7-chloro-1-pyridin-3-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C15H15ClN2O
 1
1
EC50 = 19952.62 nM
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CP0579191
(1S,3S)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile
   Show/Hide
C17H14ClFN2O
 1
1
EC50 = 19952.62 nM
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CP0563554
1-[(5-chloro-1-methylimidazol-2-yl)methyl]-2,3-dihydroindole
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C13H14ClN3
 1
1
EC50 = 22908.68 nM
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CP0220598
4-chloro-N-[(1-methylbenzimidazol-2-yl)methyl]aniline
   Show/Hide
C15H14ClN3
 1
1
EC50 > 31622.78 nM
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CP0479436
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-3,4-dimethoxy-N-methylaniline
   Show/Hide
C14H18ClN3O2
 1
1
EC50 > 31622.78 nM
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CP0485497
N-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C13H11F3N4S
 1
1
EC50 > 31622.78 nM
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CP0491410
N-[(5-propan-2-yl-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
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C14H15N3S2
 1
1
EC50 > 31622.78 nM
   TI
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CP0492472
N-[(4,5-dimethyl-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
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C13H13N3S2
 1
1
EC50 > 31622.78 nM
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CP0562267
N-(1,3-benzothiazol-2-ylmethyl)-1,2-benzothiazol-5-amine
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C15H11N3S2
 1
1
EC50 > 31622.78 nM
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CP0562268
N-[2-(5-chloro-1,3-thiazol-2-yl)propan-2-yl]-1,2-benzothiazol-5-amine
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C13H12ClN3S2
 1
1
EC50 > 31622.78 nM
   TI
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CP0563557
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1-methylbenzotriazol-5-amine
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C12H13ClN6
 1
1
EC50 > 31622.78 nM
   TI
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CP0563558
N-[(4-methyl-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
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C12H11N3S2
 1
1
EC50 > 31622.78 nM
   TI
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CP0563559
N-(1,2-benzothiazol-5-yl)-5-chloro-1,3-thiazole-2-carboxamide
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C11H6ClN3OS2
 1
1
EC50 > 31622.78 nM
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CP0567212
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-3H-benzimidazol-5-amine
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C12H12ClN5
 1
1
EC50 > 31622.78 nM
   TI
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CP0568380
N-[(5-chlorothiophen-2-yl)methyl]-1,2-benzothiazol-5-amine
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C12H9ClN2S2
 1
1
EC50 > 31622.78 nM
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CP0568385
N-(1,2-benzothiazol-5-yl)-N-[(5-chloro-1-methylimidazol-2-yl)methyl]acetamide
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C14H13ClN4OS
 1
1
EC50 > 31622.78 nM
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CP0568460
5-[(1,2-benzothiazol-5-ylamino)methyl]thiophene-2-carbonitrile
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C13H9N3S2
 1
1
EC50 > 31622.78 nM
   TI
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CP0569674
N-[(5-chloro-1-methylpyrrol-2-yl)methyl]-1,2-benzothiazol-5-amine
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C13H12ClN3S
 1
1
EC50 > 31622.78 nM
   TI
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CP0569677
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-7-methyl-1,2-benzothiazol-5-amine
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C12H10ClN3S2
 1
1
EC50 > 31622.78 nM
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CP0569687
N-[(5-chloro-1H-imidazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C11H9ClN4S
 1
1
EC50 > 31622.78 nM
   TI
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CP0569945
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-4-amine
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C11H8ClN3S2
 1
1
EC50 > 31622.78 nM
   TI
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CP0571555
N-[(4,5-dichloro-1-methylimidazol-2-yl)methyl]-1,2-benzothiazol-5-amine
   Show/Hide
C12H10Cl2N4S
 1
1
EC50 > 31622.78 nM
   TI
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CP0571556
N-benzyl-N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1,2-benzothiazol-5-amine
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C19H17ClN4S
 1
1
EC50 > 31622.78 nM
   TI
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   TS
CP0571558
7-chloro-N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
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C11H7Cl2N3S2
 1
1
EC50 > 31622.78 nM
   TI
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   TS
CP0576547
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-N-(cyclohexylmethyl)-1,2-benzothiazol-5-amine
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C19H23ClN4S
 1
1
EC50 > 31622.78 nM
   TI
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CP0568070
[(1S,3S)-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
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C16H17NO
 1
1
EC50 > 31622.78 nM
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CP0568071
(7-chloro-1-phenylisoquinolin-3-yl)methanol
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C16H12ClNO
 1
1
EC50 > 31622.78 nM
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CP0568072
[(1S,3S)-7-chloro-2-methyl-1-phenyl-3,4-dihydro-1H-isoquinolin-3-yl]methanol
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C17H18ClNO
 1
1
EC50 > 31622.78 nM
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CP0568074
[(1S,3S)-7-chloro-1-pyridin-4-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
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C15H15ClN2O
 1
1
EC50 > 31622.78 nM
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CP0569718
[(1R,3S)-7-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
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C16H16ClNO
 1
1
EC50 > 31622.78 nM
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CP0575569
[(1S,3S)-8-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
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C16H16ClNO
 1
1
EC50 > 31622.78 nM
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CP0577377
[(1S,3S)-7-chloro-1-(2-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
   Show/Hide
C17H18ClNO
 1
1
EC50 > 31622.78 nM
   TI
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   TS
CP0580165
[(1S,3R)-7-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
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C16H16ClNO
 1
1
EC50 > 31622.78 nM
   TI
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   TS