3,4,5-trimethoxy-N-[(E)-2-methyl-3-(2-methylphenyl)prop-2-enyl]-N-[2-(1-methylpyrrolidin-2-yl)ethyl]benzamide

N-methyl-N-[(3-methyl-4-oxoquinazolin-2-yl)methyl]-4-naphthalen-2-yloxybutanamide

N-methyl-N-[(3-methyl-4-oxoquinazolin-2-yl)methyl]-4-naphthalen-1-yloxybutanamide

5-(4-tert-butylphenoxy)-N-[(3-methyl-4-oxoquinazolin-2-yl)methyl]pentanamide

4-(4-tert-butylphenoxy)-N-[(3-methyl-4-oxoquinazolin-2-yl)methyl]butanamide

N-methyl-N-[(3-methyl-4-oxoquinazolin-2-yl)methyl]-4-phenoxybutanamide

tert-butyl 4-[3-[(7-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino]propyl]piperazine-1-carboxylate

N-tert-butyl-1-[3-[(7-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino]propyl]piperidine-4-carboxamide

Brintonamide D

Brintonamide E

(S)-methyl 1-((6S,9S,12R)-12-benzyl-6-isobutyl-5,9,11-trimethyl-1-((S)-1-((2R,3S)-3-methyl-2-(3-phenylpropanoyloxy)pentanoyl)pyrrolidin-2-yl)-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecane)pyrrolidine-2-carboxylate

Brintonamide C

N-[(3-methyl-4-oxoquinazolin-2-yl)methyl]-4-naphthalen-1-yloxybutanamide

2-[3-[benzyl(methyl)amino]propylamino]-7-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

tert-butyl 4-[2-[(7-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino]ethyl]piperazine-1-carboxylate

N-[(3-methyl-4-oxoquinazolin-2-yl)methyl]-4-phenoxybutanamide

7-ethyl-2-[3-[(5-methylpyridin-2-yl)amino]propylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

methyl (2S)-1-[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2R,3S)-2-hydroxy-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]-methylamino]-4-methylpentanoyl]amino]propanoyl]-methylamino]-3-phenylpropanoyl]pyrrolidine-2-carboxylate

Brintonamide B

(S)-methyl 1-((6S,9S,12R)-12-benzyl-6-isobutyl-5,9,11-trimethyl-1-((S)-1-((2R,3S)-3-methyl-2-(3-phenylpropioloyloxy)pentanoyl)pyrrolidin-2-yl)-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecane)pyrrolidine-2-carboxylate

benzyl 4-[2-[(7-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino]ethyl]piperazine-1-carboxylate

2-[2-[4-(2-cyclohexylacetyl)piperazin-1-yl]ethylamino]-7-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

2-[2-(cyclohexylamino)ethylamino]-7-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

7-ethyl-2-[2-(pyridin-2-ylamino)ethylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

2-[2-[4-(3,3-dimethylbutanoyl)piperazin-1-yl]ethylamino]-7-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

7-ethyl-2-[2-[(5-methylpyridin-2-yl)amino]ethylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

7-ethyl-2-[2-(3-methylanilino)ethylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

7-ethyl-2-[2-(4-methylanilino)ethylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

2-(2-anilinoethylamino)-7-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

7-ethyl-2-[2-[4-(2-phenylacetyl)piperazin-1-yl]ethylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

phenyl 4-[2-[(7-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino]ethyl]piperazine-1-carboxylate

7-ethyl-2-[2-(4-methylpiperazin-1-yl)ethylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

N-cyclopentyl-4-[2-[(7-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino]ethyl]piperazine-1-carboxamide

7-ethyl-2-[2-(3-fluoroanilino)ethylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

7-ethyl-2-[2-(4-methoxyanilino)ethylamino]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

ethyl 4-[2-[(7-ethyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino]ethyl]piperazine-1-carboxylate

2-[2-[4-(2-cyclopentylacetyl)piperazin-1-yl]ethylamino]-7-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

2-[2-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]ethylamino]-7-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

N-[(3R,4R)-1-cyclohexyl-3-(dimethylcarbamoyl)piperidin-4-yl]-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

methyl (3S,4S)-1-cyclohexyl-4-[[5-(2,4-difluorophenyl)-1,2-oxazole-3-carbonyl]amino]piperidine-3-carboxylate

N-[(3S,4S)-1-cyclohexyl-3-methoxypiperidin-4-yl]-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-[(3S,4S)-1-cyclohexyl-3-hydroxypiperidin-4-yl]-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-[(3S,4S)-1-cyclohexyl-3-(hydroxymethyl)piperidin-4-yl]-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-[(3S,4S)-1-cyclohexyl-3-ethoxypiperidin-4-yl]-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,3,4-oxadiazole-2-carboxamide

N-(1-cyclopentylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-cyclobutylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,2,4-oxadiazole-3-carboxamide

N-(1-benzylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-3-(2,4-difluorophenyl)-1,2-oxazole-5-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-1-(2,4-difluorophenyl)triazole-4-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-5-(4-fluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-1-(2,4-difluorophenyl)pyrazole-4-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-4-(2,4-difluorophenyl)-4-oxobutanamide

N-(1-cyclohexylpiperidin-4-yl)-5-(2-fluorophenyl)-1,2-oxazole-3-carboxamide

(3S,4S)-1-cyclohexyl-4-[[5-(2,4-difluorophenyl)-1,2-oxazole-3-carbonyl]amino]piperidine-3-carboxylic acid

5-(2,4-difluorophenyl)-N-[1-(2-methoxyethyl)piperidin-4-yl]-1,2-oxazole-3-carboxamide

N-benzyl-N-(1-cyclohexylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-6-(2,4-difluorophenyl)pyrimidine-4-carboxamide

4-(4-chloro-2-fluorophenyl)-N-(1-cyclohexylpiperidin-4-yl)-4-oxobutanamide

N-(1-cyclohexylpiperidin-4-yl)-4-(4-fluorophenyl)-4-oxobutanamide

N-(1-cyclohexylpiperidin-4-yl)-1-(4-methylphenyl)triazole-4-carboxamide

5-(2,4-difluorophenyl)-N-piperidin-4-yl-1,2-oxazole-3-carboxamide

4-(2,4-difluorophenyl)-4-oxo-N-(1-propan-2-ylpiperidin-4-yl)butanamide

N-[(4S)-1-cyclohexyl-3,3-difluoropiperidin-4-yl]-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

1-(4-methylphenyl)-N-(1-propan-2-ylpiperidin-4-yl)triazole-4-carboxamide

1-(4-methylphenyl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]triazole-4-carboxamide

N-[2-(diethylamino)-2-thiophen-3-ylethyl]-1-(4-methylphenyl)triazole-4-carboxamide

1-[4-(diethylamino)piperidin-1-yl]-4-(2,4-difluorophenyl)butane-1,4-dione

5-(4-bromophenyl)-N-(1-cyclohexylpiperidin-4-yl)-1,2-oxazole-3-carboxamide

4-(2,4-difluorophenyl)-N-[2-(dimethylamino)-2-thiophen-3-ylethyl]-4-oxobutanamide

4-(2,4-difluorophenyl)-N-[(4-methylmorpholin-2-yl)methyl]-4-oxobutanamide

4-(2,4-difluorophenyl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-oxobutanamide

N-[3-(diethylamino)propyl]-1-(4-methylphenyl)triazole-4-carboxamide

N-[2-(diethylamino)ethyl]-1-(4-methylphenyl)triazole-4-carboxamide

1-(2,4-difluorophenyl)-4-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]butane-1,4-dione

4-(2,4-difluorophenyl)-N-(1-methylpiperidin-4-yl)-4-oxobutanamide

N-[(4-methylmorpholin-2-yl)methyl]-1-(4-methylphenyl)triazole-4-carboxamide

N-[1-(2,2-difluoroethyl)piperidin-4-yl]-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-[(1-ethylpyrrolidin-2-yl)methyl]-1-(4-methylphenyl)triazole-4-carboxamide

N-[2-(diethylamino)-2-oxoethyl]-1-(4-methylphenyl)triazole-4-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-5-pyridin-3-yl-1,2-oxazole-3-carboxamide

(8-ethyl-1-oxa-4,8-diazaspiro[4.5]decan-4-yl)-[1-(4-methylphenyl)triazol-4-yl]methanone

1-(2,4-difluorophenyl)-4-(8-ethyl-1-oxa-4,8-diazaspiro[4.5]decan-4-yl)butane-1,4-dione

N-(1-cyclohexylpiperidin-4-yl)-1-phenyltriazole-4-carboxamide

[5-(4-bromophenyl)-1,2-oxazol-3-yl]-(8-ethyl-1-oxa-4,8-diazaspiro[4.5]decan-4-yl)methanone

4-(2,4-difluorophenyl)-N-[2-(dimethylamino)ethyl]-4-oxobutanamide

4-(4-bromophenyl)-N-(1-cyclohexylpiperidin-4-yl)-4-oxobutanamide

N-(4-carbamoyl-1-cyclohexylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-acetylpiperidin-4-yl)-5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxamide

N-(1-cyclohexylpiperidin-4-yl)-4-oxo-4-phenylbutanamide