| Compound ID |
Compound Name |
Compound Formula |
|
CP0580116
|
4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]azetidin-3-yl]methylamino]cyclohexane-1-carboxylic acid
Show/Hide
|
C32H34Cl2N4O3
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0571322
|
4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]azetidin-3-yl]methylamino]cyclohexane-1-carboxylic acid
Show/Hide
|
C32H34Cl2N4O3
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0571323
|
4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-fluoroazetidin-3-yl]methylamino]cyclohexane-1-carboxylic acid
Show/Hide
|
C32H33Cl2FN4O3
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0417251
|
5-cyclohexyl-3,3-dimethyl-1-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]-2-oxo-1,4-benzodiazepine-8-carbonitrile
Show/Hide
|
C31H39N5O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0535315
|
2-chloro-5,5-dimethyl-7-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]-6-oxopyrido[2,3-d][1]benzazepine-9-carbonitrile
Show/Hide
|
C29H30ClN5O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0577545
|
4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-fluoroazetidin-3-yl]methylamino]-1-methylcyclohexane-1-carboxylic acid
Show/Hide
|
C33H35Cl2FN4O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0579196
|
4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-fluoroazetidin-3-yl]methylamino]bicyclo[2.2.2]octane-1-carboxylic acid
Show/Hide
|
C34H35Cl2FN4O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0564438
|
2,9-dichloro-7-[4-[3-methoxy-3-[(oxan-4-ylamino)methyl]azetidin-1-yl]phenyl]-5,5-dimethylpyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C31H34Cl2N4O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0579195
|
methyl 1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-[(oxan-4-ylamino)methyl]azetidine-3-carboxylate
Show/Hide
|
C32H34Cl2N4O4
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0578513
|
4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-methoxyazetidin-3-yl]methylamino]cyclohexane-1-carboxylic acid
Show/Hide
|
C33H36Cl2N4O4
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0329804
|
2,9-dichloro-5,5-dimethyl-7-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]pyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C28H30Cl2N4O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0571062
|
4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-fluoroazetidin-3-yl]methylamino]-1-methylcyclohexane-1-carboxylic acid
Show/Hide
|
C33H35Cl2FN4O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0414019
|
5-cyclohexyl-3,3-dimethyl-1-[4-[2-[(1-methylsulfonylpiperidin-4-yl)amino]ethylamino]phenyl]-2-oxo-1,4-benzodiazepine-8-carbonitrile
Show/Hide
|
C32H42N6O3S
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0578267
|
4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-methoxyazetidin-3-yl]methylamino]cyclohexane-1-carboxylic acid
Show/Hide
|
C33H36Cl2N4O4
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0562182
|
2-chloro-9-fluoro-5,5-dimethyl-7-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]pyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C28H30ClFN4O2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0535314
|
2-chloro-9-methoxy-5,5-dimethyl-7-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]pyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C29H33ClN4O3
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0569986
|
2,9-dichloro-5,5-dimethyl-7-[4-[3-[(oxan-4-ylamino)methyl]azetidin-1-yl]phenyl]pyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C30H32Cl2N4O2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0403578
|
2-chloro-5,5,9-trimethyl-7-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]pyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C29H33ClN4O2
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0554299
|
1-[4-(2-aminoethylamino)phenyl]-5-cyclohexyl-3,3-dimethyl-2-oxo-1,4-benzodiazepine-8-carbonitrile
Show/Hide
|
C26H31N5O
|
1
|
| 1 |
IC50 = 730 nM
|
|
|
|
CP0550382
|
2,9-dichloro-7-[4-[3-methoxy-3-[[methyl(oxan-4-yl)amino]methyl]azetidin-1-yl]phenyl]-5,5-dimethylpyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C32H36Cl2N4O3
|
1
|
| 1 |
IC50 = 780 nM
|
|
|
|
CP0414354
|
9-chloro-2-fluoro-5,5-dimethyl-7-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]pyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C28H30ClFN4O2
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
|
CP0578512
|
2,9-dichloro-7-[4-[3-hydroxy-3-[(oxan-4-ylamino)methyl]azetidin-1-yl]phenyl]-5,5-dimethylpyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C30H32Cl2N4O3
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0579984
|
3-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-fluoroazetidin-3-yl]methylamino]cyclobutane-1-carboxylic acid
Show/Hide
|
C30H29Cl2FN4O3
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0414352
|
8-chloro-5-cyclohexyl-3,3-dimethyl-1-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]-1-benzazepin-2-one
Show/Hide
|
C31H40ClN3O2
|
1
|
| 1 |
IC50 = 970 nM
|
|
|
|
CP0437417
|
9-chloro-2,5,5-trimethyl-7-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]pyrido[2,3-d][1]benzazepin-6-one
Show/Hide
|
C29H33ClN4O2
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0576004
|
3,10-dichloro-7,7-dimethyl-5-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]benzo[d][1]benzazepin-6-one
Show/Hide
|
C29H31Cl2N3O2
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0563740
|
5-cyclohexyl-1-[4-[2-(cyclohexylamino)ethylamino]phenyl]-3,3-dimethyl-2-oxo-1,4-benzodiazepine-8-carbonitrile
Show/Hide
|
C32H41N5O
|
1
|
| 1 |
IC50 = 2300 nM
|
|
|
|
CP0414353
|
3-chloro-7,7-dimethyl-5-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]benzo[d][1]benzazepin-6-one
Show/Hide
|
C29H32ClN3O2
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0549505
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-5-cyclohexyl-3,3-dimethyl-1,4-benzodiazepin-2-one
Show/Hide
|
C25H31ClN4O
|
1
|
| 1 |
IC50 = 3500 nM
|
|
|
|
CP0549503
|
1-[4-(2-aminoethoxy)phenyl]-5-cyclohexyl-3,3-dimethyl-2-oxo-1,4-benzodiazepine-8-carbonitrile
Show/Hide
|
C26H30N4O2
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
|
CP0549504
|
1-[4-(3-aminopropylamino)phenyl]-5-cyclohexyl-3,3-dimethyl-2-oxo-1,4-benzodiazepine-8-carbonitrile
Show/Hide
|
C27H33N5O
|
1
|
| 1 |
IC50 = 4100 nM
|
|
|
|
CP0472276
|
8-chloro-5-cyclohexyl-1-[5-[2-(oxan-4-ylamino)ethylamino]pyridin-2-yl]-3-propan-2-yl-1,3,4-benzotriazepin-2-one
Show/Hide
|
C29H39ClN6O2
|
1
|
| 1 |
IC50 = 4370 nM
|
|
|
|
CP0554300
|
1-[4-(2-aminoethylamino)phenyl]-5-cyclohexyl-3,3,8-trimethyl-1,4-benzodiazepin-2-one
Show/Hide
|
C26H34N4O
|
1
|
| 1 |
IC50 = 6100 nM
|
|
|
|
CP0576163
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-5-cyclohexyl-3-methyl-3-propan-2-yl-1,4-benzodiazepin-2-one
Show/Hide
|
C27H35ClN4O
|
1
|
| 1 |
IC50 = 6800 nM
|
|
|
|
CP0414020
|
1-[4-(3-aminopropyl)phenyl]-5-cyclohexyl-3,3-dimethyl-2-oxo-1,4-benzodiazepine-8-carbonitrile
Show/Hide
|
C27H32N4O
|
1
|
| 1 |
IC50 = 7600 nM
|
|
|
|
CP0472277
|
5-cyclohexyl-3,3-dimethyl-1-[4-[2-(oxan-4-ylamino)ethylamino]phenyl]-2-oxo-1-benzazepine-8-carbonitrile
Show/Hide
|
C32H40N4O2
|
1
|
| 1 |
IC50 = 8800 nM
|
|
|
|
CP0417240
|
8-chloro-5-cyclohexyl-1-[4-(4,5-dihydro-1H-imidazol-2-ylmethyl)phenyl]-3-propan-2-yl-1,3,4-benzotriazepin-2-one
Show/Hide
|
C27H32ClN5O
|
1
|
| 1 |
IC50 = 9400 nM
|
|
|
|
CP0539595
|
1-[4-(2-aminoethylamino)phenyl]-5-cyclohexyl-8-methoxy-3,3-dimethyl-1,4-benzodiazepin-2-one
Show/Hide
|
C26H34N4O2
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0549506
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-5-cyclohexyl-3-propan-2-yl-3H-1,4-benzodiazepin-2-one
Show/Hide
|
C26H33ClN4O
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0553024
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-3,3-dimethyl-5-(1-methylcyclohexyl)-1,4-benzodiazepin-2-one
Show/Hide
|
C26H33ClN4O
|
1
|
| 1 |
IC50 = 16000 nM
|
|
|
|
CP0536632
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-3,3-dimethyl-5-(2-methylpropyl)-1,4-benzodiazepin-2-one
Show/Hide
|
C23H29ClN4O
|
1
|
| 1 |
IC50 = 23000 nM
|
|
|
|
CP0564384
|
1-[4-(2,9-dichloro-5,5-dimethyl-6-oxopyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-[(oxan-4-ylamino)methyl]azetidine-3-carboxylic acid
Show/Hide
|
C31H32Cl2N4O4
|
1
|
| 1 |
IC50 = 23000 nM
|
|
|
|
CP0554301
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-5-cyclohexyl-3H-1,4-benzodiazepin-2-one
Show/Hide
|
C23H27ClN4O
|
1
|
| 1 |
IC50 = 38000 nM
|
|
|
|
CP0530307
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-5-cyclohexyl-3-(dimethylamino)-3H-1,4-benzodiazepin-2-one
Show/Hide
|
C25H32ClN5O
|
1
|
| 1 |
IC50 = 44000 nM
|
|
|
|
CP0559470
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-3,3-dimethyl-5-phenyl-1,4-benzodiazepin-2-one
Show/Hide
|
C25H25ClN4O
|
1
|
| 1 |
IC50 = 45000 nM
|
|
|
|
CP0571794
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-4-cyclohexyl-3H-1,4-benzodiazepine-2,5-dione
Show/Hide
|
C23H27ClN4O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0571795
|
1-[4-(2-aminoethylamino)phenyl]-8-chloro-4-cyclohexyl-3,5-dihydro-1,4-benzodiazepin-2-one
Show/Hide
|
C23H29ClN4O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0400098
|
5-cyclohexyl-1-[4-[2-(1H-imidazol-2-yl)ethylamino]phenyl]-3,8-dimethyl-1,3,4-benzotriazepin-2-one
Show/Hide
|
C27H32N6O
|
1
|
| 1 |
Kd = 2884.03 nM
|
|
|
