Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT02536 , Diacylglycerol O-acyltransferase 1
Gene Name DGAT1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID O75907
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT02536
 
Compound ID Compound Name Compound Formula
CP0422892
4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]pyridin-2-yl}piperazine-1-carboxylic Acid Ethyl Ester
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C23H22F3N5O4
 1
1
EC50 = 93 nM
   TI
   LI
   LO
   TS
CP0372079
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid[6-(4-Cyclopropanecarbonylpiperazin-1-yl)pyridin-3-yl]-amide
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C24H22F3N5O3
 1
1
EC50 = 138 nM
   TI
   LI
   LO
   TS
CP0372080
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid[4-(4-Cyclopropanecarbonylpiperazin-1-yl)phenyl]amide
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C25H23F3N4O3
 1
1
EC50 = 165 nM
   TI
   LI
   LO
   TS
CP0494540
4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperazine-1-carboxylic Acid Methyl Ester
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C23H21F3N4O4
 1
1
EC50 = 190 nM
   TI
   LI
   LO
   TS
CP0494541
4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]pyridin-2-yl}piperazine-1-carboxylic Acid Methyl Ester
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C22H20F3N5O4
 1
1
EC50 = 216 nM
   TI
   LI
   LO
   TS
CP0478472
5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]-3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-carboxylic AcidMethyl Ester
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C23H21F3N4O4
 1
1
EC50 = 219 nM
   TI
   LI
   LO
   TS
CP0498653
4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperidine-1-carbonyl)-cis-cyclohexanecarboxylic Acid
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C30H30F3N3O5
 1
1
EC50 = 220 nM
   TI
   LI
   LO
   TS
CP0489764
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid[6-(3-Ethoxyazetidin-1-yl)pyridin-3-yl]amide
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C21H19F3N4O3
 1
1
EC50 = 228 nM
   TI
   LI
   LO
   TS
CP0372083
N-[4-[1-(cyclopropanecarbonyl)piperidin-4-yl]phenyl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C26H24F3N3O3
 1
1
EC50 = 362 nM
   TI
   LI
   LO
   TS
CP0372077
4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperazine-1-carbonyl)-cis-cyclohexanecarboxylic Acid
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C29H29F3N4O5
 1
1
EC50 = 365 nM
   TI
   LI
   LO
   TS
CP0273348
4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperidine-1-carboxylic Acid Methyl Ester
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C24H22F3N3O4
 2
1
EC50 = 371 nM
   TI
   LI
   LO
   TS
2
EC50 < 1000 nM
   TI
   LI
   LO
   TS
CP0498948
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid(1'-Cyclopropanecarbonyl-1',2',3',4',5',6'-hexahydro[2,4']bipyridinyl-5-yl)amide
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C25H23F3N4O3
 1
1
EC50 = 378 nM
   TI
   LI
   LO
   TS
CP0498947
4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]-pyrimidin-2-yl}piperazine-1-carboxylic Acid Methyl Ester
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C21H19F3N6O4
 1
1
EC50 = 410 nM
   TI
   LI
   LO
   TS
CP0275315
N-(6-morpholin-4-ylpyridin-3-yl)-5-phenyl-2-(trifluoromethyl)furan-3-carboxamide
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C21H18F3N3O3
 1
1
EC50 = 490 nM
   TI
   LI
   LO
   TS
CP0050575
4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperidine-1-carbonyl)-trans-cyclohexanecarboxylic Acid
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C30H30F3N3O5
 1
1
EC50 = 493 nM
   TI
   LI
   LO
   TS
CP0498434
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid{2-[(2-Methoxyethyl)methylamino]pyrimidin-5-yl}amide
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C19H18F3N5O3
 1
1
EC50 = 534 nM
   TI
   LI
   LO
   TS
CP0137702
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid{6-[(2-Methoxyethyl)methylamino]pyridin-3-yl}amide
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C20H19F3N4O3
 2
1
EC50 = 660 nM
   TI
   LI
   LO
   TS
2
EC50 = 661 nM
   TI
   LI
   LO
   TS
CP0291275
N-(6-morpholin-4-ylpyridin-3-yl)-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C20H17F3N4O3
 1
1
EC50 = 840 nM
   TI
   LI
   LO
   TS
CP0205880
N-[6-(diethylamino)pyridin-3-yl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C20H19F3N4O2
 1
1
EC50 = 910 nM
   TI
   LI
   LO
   TS
CP0422894
4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperazine-1-carbonyl)-trans-cyclohexanecarboxylic Acid
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C29H29F3N4O5
 1
1
EC50 = 1070 nM
   TI
   LI
   LO
   TS
CP0037325
2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl}phenyl)cyclohexyl]acetic acid
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C22H26N4O3
 1
1
EC50 = 1436 nM
   TI
   LI
   LO
   TS
CP0260178
N-(2-morpholin-4-ylpyrimidin-5-yl)-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C19H16F3N5O3
 1
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0372082
4-(4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]pyridin-2-yl}piperazine-1-carbonyl)-trans-cyclohexanecarboxylic Acid
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C28H28F3N5O5
 1
1
EC50 = 1764 nM
   TI
   LI
   LO
   TS
CP0422891
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid{4-[(2-Methoxyethyl)methylamino]phenyl}amide
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C21H20F3N3O3
 1
1
EC50 = 1803 nM
   TI
   LI
   LO
   TS
CP0422893
4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]-3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-carbonyl}-transcyclohexanecarboxylic Acid
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C29H29F3N4O5
 1
1
EC50 = 2363 nM
   TI
   LI
   LO
   TS
CP0191591
N-(3-oxo-1-propyl-2H-indazol-5-yl)-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C21H17F3N4O3
 1
1
EC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0151924
N-(4-morpholin-4-ylphenyl)-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C21H18F3N3O3
 1
1
EC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0260179
5-chloro-N-(6-morpholin-4-ylpyridin-3-yl)-2-phenyl-1,3-oxazole-4-carboxamide
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C19H17ClN4O3
 1
1
EC50 = 2990 nM
   TI
   LI
   LO
   TS
CP0275314
5-ethyl-N-(6-morpholin-4-ylpyridin-3-yl)-2-phenyl-1,3-oxazole-4-carboxamide
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C21H22N4O3
 1
1
EC50 = 3420 nM
   TI
   LI
   LO
   TS
CP0291276
N-(2-morpholin-4-yl-1,3-thiazol-5-yl)-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C18H15F3N4O3S
 1
1
EC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0372078
(S)-2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid-[2-(3-Hydroxypyrrolidin-1-yl)pyrimidin-5-yl]amide
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C19H16F3N5O3
 1
1
EC50 = 5660 nM
   TI
   LI
   LO
   TS
CP0291277
4-methyl-N-(6-morpholin-4-ylpyridin-3-yl)-2-phenyl-1,3-oxazole-5-carboxamide
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C20H20N4O3
 1
1
EC50 = 7460 nM
   TI
   LI
   LO
   TS
CP0260180
N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C19H17F3N4O3
 1
1
EC50 = 8090 nM
   TI
   LI
   LO
   TS
CP0077134
N-[6-[ethyl(2-methoxyethyl)amino]pyridin-3-yl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C21H21F3N4O3
 1
1
EC50 = 8900 nM
   TI
   LI
   LO
   TS
CP0339410
N-[6-(2-methoxyethylamino)pyridin-3-yl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C19H17F3N4O3
 1
1
EC50 = 11060 nM
   TI
   LI
   LO
   TS
CP0275237
4-methyl-N-(6-morpholin-4-ylpyridin-3-yl)-2-phenyl-1,3-thiazole-5-carboxamide
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C20H20N4O2S
 1
1
EC50 = 11800 nM
   TI
   LI
   LO
   TS
CP0425840
(1-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]pyridin-2-yl}azetidin-3-yloxy)acetic Acid
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C21H17F3N4O5
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0460210
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid{6-[(2-Methoxyethyl)methylamino]pyridin-3-yl}methylamide
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C21H21F3N4O3
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0494378
2-Methyl-5-trifluoromethyloxazole-4-carboxylic Acid{6-[(2-Methoxyethyl)methylamino]pyridin-3-yl}amide
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C15H17F3N4O3
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0498945
2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid[6-(3,3-Difluoroazetidin-1-yl)pyridin-3-yl]amide
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C19H13F5N4O2
 1
1
EC50 = 25000 nM
   TI
   LI
   LO
   TS
CP0260181
N-[6-[(2-methoxyacetyl)-methylamino]pyridin-3-yl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
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C20H17F3N4O4
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS