Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT01111 , 11-beta-hydroxysteroid dehydrogenase type 2
Gene Name HSD11B2
Organism Mus musculus, Mouse
Protein Classification Enzyme
Uniprot ID P51661
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT01111
 
Compound ID Compound Name Compound Formula
CP0456289
5-(4-(5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-ol
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C21H35N3O
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0221520
3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine
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C21H35N3
 1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0050383
4-methyl-3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C23H30F3N3
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0087093
3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C22H28F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0100579
3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C21H26F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0303155
3-(4-((4-chlorophenoxy)methyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C25H25ClF3N3O
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0438227
4-methyl-3-(4-(2-(methylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C21H26F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0438228
N-[[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]-1-bicyclo[2.2.2]octanyl]methyl]ethanesulfonamide
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C21H27F3N4O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0438231
3-(2-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole
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C21H28ClN3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0456287
3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C22H28F3N3OS
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0456288
3-(2-bromophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole
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C21H28BrN3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0456290
5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-ol
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C23H30F3N3O
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0459166
3-(4-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole
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C21H28ClN3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0459200
4-methyl-3-(4-((4-(methylsulfonyl)phenoxy)methyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C26H28F3N3O3S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0459201
4-methyl-3-(4-(2-(2,2,2-trifluoroethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C22H25F6N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0459202
3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-o-tolyl-4H-1,2,4-triazole
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C22H31N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0465191
3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-fluorophenyl)-4-methyl-4H-1,2,4-triazole
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C21H28FN3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0465193
3-(4-(4,4-difluoropentyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C23H28F5N3
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0467657
3-(4-(3-(ethylsulfonyl)propyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C23H30F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0467659
3-(4-(2-(isopropylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C23H30F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0467674
N-[[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]-1-bicyclo[2.2.2]octanyl]methyl]propane-1-sulfonamide
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C22H29F3N4O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0474206
3-(4-(2-(tert-butylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C24H32F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0474208
3-(4-(4-fluoropentyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C23H29F4N3
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0478360
3-(4-(2-(4-fluorophenylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C26H27F4N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0478665
3-(4-(2-(ethylthio)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C22H28F3N3S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0479033
N-[[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]-1-bicyclo[2.2.2]octanyl]methyl]methanesulfonamide
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C20H25F3N4O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0480447
3-chloro-4-(5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol
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C21H28ClN3O3S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0480452
3-(4-(ethoxymethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C21H26F3N3O
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0488470
4-methyl-3-(4-(2-(propylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C23H30F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0488471
4-methyl-3-(2-(trifluoromethyl)phenyl)-5-(4-(2-(trifluoromethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4H-1,2,4-triazole
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C21H23F6N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0494394
4-methyl-3-(4-(2-(phenylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C26H28F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0494395
3-(4-(4-methoxybutyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C23H30F3N3O
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0499209
5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-one
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C23H28F3N3O
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0500109
3-(3-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole
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C21H28ClN3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS
CP0506643
3-(4-(4-(ethylsulfonyl)butyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole
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C24H32F3N3O2S
 1
1
IC50 > 4000 nM
   TI
   LI
   LO
   TS