Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT00983 , Kappa-type opioid receptor
Gene Name OPRK1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P41145
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT00983
 
Compound ID Compound Name Compound Formula
CP0408878
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-phenylprop-2-enamide
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C30H34N2O5
 1
1
EC50 = 0.0222 nM
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CP0236464
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C28H32N2O6
 1
1
EC50 = 0.025 nM
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CP0489070
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-pyridin-4-ylprop-2-enamide
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C29H33N3O5
 1
1
EC50 = 0.0257 nM
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CP0476305
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-thiophen-3-ylprop-2-enamide
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C28H32N2O5S
 1
1
EC50 = 0.028 nM
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CP0446657
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-pyridin-2-ylprop-2-enamide
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C29H33N3O5
 1
1
EC50 = 0.0283 nM
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CP0476306
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(4-chlorophenyl)-N-methylprop-2-enamide
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C30H33ClN2O5
 1
1
EC50 = 0.0288 nM
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CP0036843
(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(furan-3-yl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester
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C23H28O8
 4
1
EC50 = 0.03 nM
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2
EC50 = 0.04 nM
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3
EC50 = 0.042 nM
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4
EC50 = 0.21 nM
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CP0489069
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-(4-methylphenyl)prop-2-enamide
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C31H36N2O5
 1
1
EC50 = 0.0494 nM
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CP0446656
N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-phenylprop-2-ynamide
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C30H32N2O5
 1
1
EC50 = 0.0799 nM
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CP0476303
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(4-hydroxyphenyl)-N-methylprop-2-enamide
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C30H34N2O6
 1
1
EC50 = 0.0953 nM
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CP0408877
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-2-yl)-N-methylprop-2-enamide
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C28H32N2O6
 1
1
EC50 = 0.122 nM
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CP0476304
(E)-N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-pyridin-3-ylprop-2-enamide
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C29H33N3O5
 1
1
EC50 = 0.291 nM
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CP0553151
methyl (2S,4aR,6aR,7R,10aR,10bR)-9-acetyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
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C23H26O8
 1
1
EC50 = 0.56 nM
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CP0446643
methyl (2S,4aR,6aR,7R,9R,10aS,10bR)-2-(furan-3-yl)-6a,10b-dimethyl-4,5',10-trioxospiro[1,2,4a,5,6,7,8,10a-octahydrobenzo[f]isochromene-9,2'-oxolane]-7-carboxylate
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C24H28O8
 1
1
EC50 = 0.6 nM
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CP0408880
N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-phenylpropanamide
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C30H36N2O5
 1
1
EC50 = 1.04 nM
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CP0440501
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-phenyl-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C24H30Cl2N4O
 1
1
EC50 = 1.3 nM
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CP0490521
2-(naphthalen-1-yl)-1-(4-phenyl-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C27H31N3O
 1
1
EC50 = 1.6 nM
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CP0529589
2-(5-chlorobenzo[b]thiophen-3-yl)-1-(4-phenyl-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C25H28ClN3OS
 1
1
EC50 = 2 nM
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CP0130404
methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate
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C21H26O7
 1
1
EC50 = 2.4 nM
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CP0440500
2-((3,4-dichlorophenyl)(methyl)amino)-1-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethanone
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C19H27Cl2N3O
 1
1
EC50 = 3 nM
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CP0457675
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-(methylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C19H28Cl2N4O3S
 1
1
EC50 = 3 nM
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CP0511393
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-(3-methoxyphenyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C25H32Cl2N4O2
 1
1
EC50 = 3.2 nM
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CP0497805
1-(4-(3-chlorophenyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-((3,4-dichlorophenyl)(methyl)amino)ethanone
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C24H29Cl3N4O
 1
1
EC50 = 4 nM
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CP0500696
1-(4-phenyl-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-(2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)ethanone
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C25H28F3N5O
 1
1
EC50 = 4 nM
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CP0537531
methyl (2S,4aR,6aR,7R,10aR,10bR)-2-(furan-3-yl)-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
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C21H24O7
 1
1
EC50 = 4.9 nM
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CP0483119
N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-2-phenoxyacetamide
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C29H34N2O6
 1
1
EC50 = 5.04 nM
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CP0530340
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-(3,4-difluorophenyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C24H28Cl2F2N4O
 1
1
EC50 = 6.3 nM
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CP0475335
N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-4-phenylbutanamide
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C31H38N2O5
 1
1
EC50 = 7.51 nM
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CP0519364
methyl (3S,4aS,5S,6S,8aR)-3-(furan-3-yl)-4a,6-dimethyl-1-oxo-6-[(2R)-1,4,4-trimethoxy-1-oxobutan-2-yl]-3,4,5,7,8,8a-hexahydroisochromene-5-carboxylate
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C24H34O9
 1
1
EC50 = 11.7 nM
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CP0446645
methyl (3S,4aS,5S,6S,8aR)-6-[(2R)-4-acetyloxy-1-methoxy-1-oxobutan-2-yl]-3-(furan-3-yl)-4a,6-dimethyl-1-oxo-3,4,5,7,8,8a-hexahydroisochromene-5-carboxylate
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C24H32O9
 1
1
EC50 = 13 nM
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CP0408199
methyl (3S,4aS,5S,6S,8aR)-3-(furan-3-yl)-6-[(2R)-1-methoxy-1,4-dioxobutan-2-yl]-4a,6-dimethyl-1-oxo-3,4,5,7,8,8a-hexahydroisochromene-5-carboxylate
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C22H28O8
 1
1
EC50 = 30 nM
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CP0479295
ethyl 3-[(1S,5R,9R)-5-(3-hydroxyphenyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-9-yl]propanoate
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C27H35NO3
 1
1
EC50 = 35.3 nM
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CP0457676
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-(3-methoxyphenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C25H32Cl2N4O4S
 1
1
EC50 = 79 nM
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CP0280997
(2S,4aR,6aR,7R,9R,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
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C23H28O8
 1
1
EC50 = 110 nM
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CP0444863
methyl (2S,4aR,6aR,7R,10aR,10bR)-9-(2-fluorobenzoyl)oxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
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C28H27FO8
 1
1
EC50 = 160 nM
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CP0036846
(3S,4aR,4bS,6S,8R,8aR,10aR)-6-Benzoyloxy-3-furan-3-yl-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C28H30O8
 1
1
EC50 = 170 nM
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CP0537562
1-(4-(3-chlorophenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-((3,4-dichlorophenyl)(methyl)amino)ethanone
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C24H29Cl3N4O3S
 1
1
EC50 = 200 nM
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CP0460431
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-(phenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C24H30Cl2N4O3S
 1
1
EC50 = 250 nM
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CP0444862
methyl (2S,4aR,6aR,7R,10aR,10bR)-9-(4-fluorobenzoyl)oxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
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C28H27FO8
 1
1
EC50 = 260 nM
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CP0493256
5-chloro-3-(2-(4-(3-methoxyphenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]oxazol-2(3H)-one
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C25H29ClN4O6S
 1
1
EC50 = 320 nM
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CP0530309
5-chloro-3-(2-(4-(3,4-dimethoxyphenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]oxazol-2(3H)-one
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C26H31ClN4O7S
 1
1
EC50 = 320 nM
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CP0469090
(1R,5S,9S)-5-(3-hydroxyphenyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-9-ol
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C22H27NO2
 1
1
EC50 = 322.8 nM
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CP0479298
methyl 3-[(1S,5R,9S)-5-(3-hydroxyphenyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-9-yl]propanoate
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C26H33NO3
 1
1
EC50 = 322.8 nM
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CP0000305
(-)-(etorphine)
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C17H19NO3
 1
1
EC50 = 330 nM
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CP0386400
3-(2-oxo-2-(4-phenyl-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethyl)benzo[d]oxazol-2(3H)-one
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C24H28N4O3
 1
1
EC50 = 400 nM
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CP0436115
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-(3,4-difluorophenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C24H28Cl2F2N4O3S
 1
1
EC50 = 400 nM
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CP0457673
3-(4-(2-(5-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazin-1-ylsulfonyl)benzonitrile
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C25H26ClN5O5S
 1
1
EC50 = 630 nM
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CP0529590
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-isonicotinoyl-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
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C24H29Cl2N5O2
 1
1
EC50 = 630 nM
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CP0457677
1-(4-(4-chlorophenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-((3,4-dichlorophenyl)(methyl)amino)ethanone
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C24H29Cl3N4O3S
 1
1
EC50 = 790 nM
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CP0490513
3-(2-(4-(5-bromo-2-methoxyphenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-oxoethyl)-5-chlorobenzo[d]oxazol-2(3H)-one
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C25H28BrClN4O6S
 1
1
EC50 = 790 nM
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CP0490514
5-chloro-3-(2-oxo-2-(4-(phenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethyl)benzo[d]oxazol-2(3H)-one
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C24H27ClN4O5S
 1
1
EC50 = 790 nM
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CP0457674
3-(2-oxo-2-(4-(phenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethyl)benzo[d]oxazol-2(3H)-one
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C24H28N4O5S
 1
1
EC50 = 1000 nM
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CP0490520
5-chloro-3-(2-(4-(2-chloro-5-(trifluoromethyl)phenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]oxazol-2(3H)-one
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C25H25Cl2F3N4O5S
 1
1
EC50 = 1000 nM
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CP0436113
N-[4-[4-[2-(5-chloro-2-oxo-1,3-benzoxazol-3-yl)acetyl]-3-(pyrrolidin-1-ylmethyl)piperazin-1-yl]sulfonylphenyl]acetamide
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C26H30ClN5O6S
 1
1
EC50 = 1300 nM
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CP0436114
3-(2-(4-(2-bromo-3,4-dimethoxyphenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-oxoethyl)-5-chlorobenzo[d]oxazol-2(3H)-one
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C26H30BrClN4O7S
 1
1
EC50 = 1300 nM
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CP0490519
5-chloro-3-(2-(4-(4-methoxyphenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]oxazol-2(3H)-one
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C25H29ClN4O6S
 1
1
EC50 = 2000 nM
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CP0528436
5-chloro-3-(2-oxo-2-(2-(pyrrolidin-1-ylmethyl)-4-(3-(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)ethyl)benzo[d]oxazol-2(3H)-one
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C25H26ClF3N4O5S
 1
1
EC50 = 2000 nM
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CP0528986
4-(4-(2-(5-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazin-1-ylsulfonyl)benzoic acid
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C25H27ClN4O7S
 1
1
EC50 = 2000 nM
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CP0530310
3-(2-(4-(2-bromophenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-oxoethyl)-5-chlorobenzo[d]oxazol-2(3H)-one
   Show/Hide
C24H26BrClN4O5S
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0429777
(1R,2S,3S,5R,8R,11R,12R)-5-(furan-3-yl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadecane-7,13-dione
   Show/Hide
C20H24O6
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0436826
4-(1-(2-((3,4-dichlorophenyl)(methyl)amino)acetyl)-2-(pyrrolidin-1-ylmethyl)piperazine-4-carbonyl)benzonitrile
   Show/Hide
C26H29Cl2N5O2
 1
1
EC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0528988
4-(2-((3,4-dichlorophenyl)(methyl)amino)acetyl)-N-phenyl-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxamide
   Show/Hide
C25H31Cl2N5O2
 1
1
EC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0476111
[(1R,2S,3S,5R,8R,11R,12R)-5-(furan-3-yl)-3,11-dimethyl-7,13-dioxo-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-en-12-yl] (E)-3-phenylprop-2-enoate
   Show/Hide
C29H28O7
 1
1
EC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0457672
4-(4-(2-(5-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazin-1-ylsulfonyl)-2-hydroxybenzoic acid
   Show/Hide
C25H27ClN4O8S
 1
1
EC50 = 7900 nM
   TI
   LI
   LO
   TS
CP0490522
1-(4-benzoyl-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-((3,4-dichlorophenyl)(methyl)amino)ethanone
   Show/Hide
C25H30Cl2N4O2
 1
1
EC50 = 7900 nM
   TI
   LI
   LO
   TS
CP0412868
[(1R,2S,3S,5R,8R,11R,12R)-5-(furan-3-yl)-3,11-dimethyl-7,13-dioxo-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-en-12-yl] acetate
   Show/Hide
C22H24O7
 1
1
EC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0460432
1-(4-(3-chlorobenzoyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)-2-((3,4-dichlorophenyl)(methyl)amino)ethanone
   Show/Hide
C25H29Cl3N4O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0522667
2-((3,4-dichlorophenyl)(methyl)amino)-1-(4-(3,4-dimethoxybenzoyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethanone
   Show/Hide
C27H34Cl2N4O4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0388563
(3S,4aR,4bS,8R,8aR,10aR)-3-Furan-3-yl-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthrene-8-carboxyli c acid methyl ester
   Show/Hide
C21H26O6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0408198
(3R)-3-[(3S,4aS,5S,6S,8aR)-3-(furan-3-yl)-5-methoxycarbonyl-4a,6-dimethyl-1-oxo-3,4,5,7,8,8a-hexahydroisochromen-6-yl]-4-methoxy-4-oxobutanoic acid
   Show/Hide
C22H28O9
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0482740
methyl (2S,4aR,6aS,7R,10bS)-2-(furan-3-yl)-10-hydroxy-6a,10b-dimethyl-4,9-dioxo-2,4a,5,6,7,8-hexahydro-1H-benzo[f]isochromene-7-carboxylate
   Show/Hide
C21H24O7
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0520164
methyl (3S,4aS,5S,6S,8aR)-3-(furan-3-yl)-6-[(2R)-4-hydroxy-1-methoxy-1-oxobutan-2-yl]-4a,6-dimethyl-1-oxo-3,4,5,7,8,8a-hexahydroisochromene-5-carboxylate
   Show/Hide
C22H30O8
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0469087
3-[(1S,5R,9R)-2-(2-phenylethyl)-9-propyl-2-azabicyclo[3.3.1]nonan-5-yl]phenol
   Show/Hide
C25H33NO
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0469092
methyl 3-[(1S,5R,9R)-5-(3-hydroxyphenyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-9-yl]propanoate
   Show/Hide
C26H33NO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0479294
3-[(1S,5R,9R)-9-[(E)-3-hydroxyprop-1-enyl]-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-5-yl]phenol
   Show/Hide
C25H31NO2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0479296
methyl (E)-3-[(1S,5R,9R)-5-(3-hydroxyphenyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-9-yl]prop-2-enoate
   Show/Hide
C26H31NO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0552043
3-[(1S,5R,9R)-5-(3-hydroxyphenyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-9-yl]propanoic acid
   Show/Hide
C25H31NO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0552077
3-[(1R,5S,9S)-9-(3-hydroxypropyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-5-yl]phenol
   Show/Hide
C25H33NO2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0552078
methyl 3-[(1R,5S,9S)-5-(3-hydroxyphenyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-9-yl]propanoate
   Show/Hide
C26H33NO3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0552079
3-[(1S,5R,9R)-9-(3-hydroxypropyl)-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-5-yl]phenol
   Show/Hide
C25H33NO2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0043301
(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide
   Show/Hide
C26H35N5O6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0444832
methyl (2S,4aR,6aR,7R,10aR,10bR)-2-(furan-3-yl)-6a,10b-dimethyl-9-(4-methylbenzoyl)oxy-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
   Show/Hide
C29H30O8
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0444833
[(2S,4aR,6aR,7R,10aR,10bR)-7-acetyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromen-9-yl] 3-fluorobenzoate
   Show/Hide
C28H27FO8
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0444834
methyl (2S,4aR,6aR,7R,10aR,10bR)-2-(furan-3-yl)-6a,10b-dimethyl-9-(4-nitrobenzoyl)oxy-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
   Show/Hide
C28H27NO10
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0444846
methyl (2S,4aR,6aR,7R,10aR,10bR)-9-(4-chlorobenzoyl)oxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
   Show/Hide
C28H27ClO8
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0444864
methyl (2S,4aR,6aR,7R,10aR,10bR)-9-benzoyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
   Show/Hide
C28H28O8
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0444865
methyl (2S,4aR,6aR,7R,10aR,10bR)-2-(furan-3-yl)-9-(3-methoxybenzoyl)oxy-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
   Show/Hide
C29H30O9
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0451330
methyl (2S,4aR,6aR,7R,10aR,10bR)-2-(furan-3-yl)-9-(4-methoxybenzoyl)oxy-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
   Show/Hide
C29H30O9
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0553129
[(2S,4aR,6aR,7R,9S,10aR,10bR)-9-benzamido-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromen-7-yl] acetate
   Show/Hide
C28H31NO7
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0553150
methyl (2S,4aR,6aR,7R,9R,10aS,10bR)-9-benzoyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate
   Show/Hide
C28H30O8
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0485160
(1R,2S,3S,5R,8R,11R,12R)-5-(furan-3-yl)-12-(methoxymethoxy)-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
   Show/Hide
C22H26O7
 1
1
EC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0557139
(1S,2S,3S,5R,8R,11R,12S,15S,16R)-5-(furan-3-yl)-12,15,16-trihydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadecane-7,13-dione
   Show/Hide
C20H24O8
 1
1
EC50 = 16000 nM
   TI
   LI
   LO
   TS
CP0402778
(1R,2S,3S,5R,8R,11R,12R)-5-(furan-3-yl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
   Show/Hide
C20H22O6
 1
1
EC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0402781
(1R,2S,3S,5R,8R,11R,12R)-5-(2-bromofuran-3-yl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
   Show/Hide
C20H21BrO6
 1
1
EC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0542893
(1S,2S,3S,5R,8R,11R,12R,15R,16R)-15,16-dibromo-5-(2-bromofuran-3-yl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadecane-7,13-dione
   Show/Hide
C20H21Br3O6
 1
1
EC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0557138
[(1S,2S,3S,5R,8R,11R,12S,15R,16R)-16-acetyloxy-5-(furan-3-yl)-12-hydroxy-3,11-dimethyl-7,13-dioxo-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadecan-15-yl] acetate
   Show/Hide
C24H28O10
 1
1
EC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0408879
N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methylbenzamide
   Show/Hide
C28H32N2O5
 1
1
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0475334
N-[(4R,4aS,7R,7aR,12bS,13S)-3-(cyclopropylmethyl)-4a,9,13-trihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-2-phenylacetamide
   Show/Hide
C29H34N2O5
 1
1
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0041613
Anapriline
   Show/Hide
C16H21NO2
 2
1
EC50 > 5011.87 nM
   TI
   LI
   LO
   TS
2
IC50 > 5011.87 nM
   TI
   LI
   LO
   TS
CP0066236
1-(dimethylamino)-3-[(2-methyl-1H-1,2-benzazaborinin-8-yl)oxy]propan-2-ol
   Show/Hide
C14H21BN2O2
 2
1
EC50 > 5011.87 nM
   TI
   LI
   LO
   TS
2
IC50 > 5011.87 nM
   TI
   LI
   LO
   TS
CP0366351
1-(dimethylamino)-3-[(2-methyl-1H-1,2-benzazaborinin-5-yl)oxy]propan-2-ol
   Show/Hide
C14H21BN2O2
 2
1
EC50 > 5011.87 nM
   TI
   LI
   LO
   TS
2
IC50 > 5011.87 nM
   TI
   LI
   LO
   TS
CP0390637
(2E)-1-[6-[[2-[[2-[[2-[[2-[3-[[amino-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]amino]methylidene]amino]propylamino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-6-oxohexyl]-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethyl-5-sulfoindol-1-ium-2-yl)penta-2,4-dienylidene]indole-5-sulfonate
   Show/Hide
C70H84N12O14S2
 1
1
Kd = 4.8 nM
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   TS
CP0391391
(2E)-1-[6-[3-[[amino-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]amino]methylidene]amino]propylamino]-6-oxohexyl]-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethyl-5-sulfoindol-1-ium-2-yl)penta-2,4-dienylidene]indole-5-sulfonate
   Show/Hide
C62H72N8O10S2
 1
1
Kd = 9.5 nM
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   LO
   TS
CP0390635
(2E)-1-[6-[3-[[amino-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]amino]methylidene]amino]propylamino]-6-oxohexyl]-3,3-dimethyl-2-[(E)-3-(1,3,3-trimethyl-5-sulfoindol-1-ium-2-yl)prop-2-enylidene]indole-5-sulfonate
   Show/Hide
C60H70N8O10S2
 1
1
Kd = 18.8 nM
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CP0049540
(S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-acetamide(ICI 199441)
   Show/Hide
C21H24Cl2N2O
 1
1
Ki = 0.044 nM
   TI
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   TS
CP0440569
2-[6-[benzyl(methyl)sulfamoyl]-1,3-benzodioxol-5-yl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
   Show/Hide
C30H35N3O5S
 1
1
Ki = 0.19 nM
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   TS
CP0296160
(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoic acid
   Show/Hide
C99H155N31O23
 1
1
Ki = 0.21 nM
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CP0478166
2-[6-(dimethylsulfamoyl)-1,3-benzodioxol-5-yl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
   Show/Hide
C24H31N3O5S
 1
1
Ki = 0.22 nM
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   TS
CP0462665
2-(4,5-dimethoxy-2-pyrrolidin-1-ylsulfonylphenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
   Show/Hide
C27H37N3O5S
 1
1
Ki = 0.31 nM
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   TS
CP0435080
2-[2-(dimethylsulfamoyl)-4,5-dimethoxyphenyl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
   Show/Hide
C25H35N3O5S
 1
1
Ki = 0.5 nM
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   TS
CP0436371
2-[6-(dimethylsulfamoyl)-1,3-benzodioxol-5-yl]-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
   Show/Hide
C24H31N3O6S
 1
1
Ki = 0.54 nM
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   TS
CP0436366
2-(4,5-dimethoxy-2-morpholin-4-ylsulfonylphenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
   Show/Hide
C27H37N3O6S
 1
1
Ki = 0.55 nM
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   TS
CP0435079
2-[2-[benzyl(methyl)sulfamoyl]-4,5-dimethoxyphenyl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
   Show/Hide
C31H39N3O5S
 1
1
Ki = 0.68 nM
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CP0436370
2-(1,3-benzodioxol-5-yl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
   Show/Hide
C22H26N2O3
 1
1
Ki = 0.7 nM
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   TS
CP0399637
2-(4,5-dimethoxy-2-pyrrolidin-1-ylsulfonylphenyl)-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
   Show/Hide
C27H37N3O6S
 1
1
Ki = 1.1 nM
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CP0509939
2-[4,5-dimethoxy-2-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
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C28H40N4O5S
 1
1
Ki = 1.3 nM
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CP0436372
2-(4,5-dimethoxy-2-morpholin-4-ylsulfonylphenyl)-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
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C27H37N3O7S
 1
1
Ki = 1.4 nM
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CP0399638
2-[2-(dimethylsulfamoyl)-4,5-dimethoxyphenyl]-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
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C25H35N3O6S
 1
1
Ki = 1.6 nM
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CP0435078
2-(3,4-dimethoxyphenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
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C23H30N2O3
 1
1
Ki = 2.8 nM
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CP0436368
2-[4,5-dimethoxy-2-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methylacetamide
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C28H40N4O6S
 1
1
Ki = 3.8 nM
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