| Compound ID |
Compound Name |
Compound Formula |
|
CP0552260
|
1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H28N4O
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0558080
|
1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H27FN4O
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0552474
|
1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]-5'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H27FN4O
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0552476
|
Rv-521
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|
C23H22F4N4O
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0561780
|
1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]-7'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C23H22F4N4O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0559388
|
1'-[[5-(aminomethyl)-1-(oxan-4-yl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H25FN4O2
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0565226
|
1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]-6'-chlorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H27ClN4O
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0563526
|
1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]-7'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H27FN4O
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0558081
|
1'-[[5-(aminomethyl)-1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C23H25FN4O2
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0485267
|
1'-[[5-(aminomethyl)-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C23H25FN4O3S
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0561781
|
1'-[[5-(aminomethyl)-1-(4-hydroxycyclohexyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C25H27FN4O2
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0573771
|
2-[(6'-fluoro-2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl)methyl]-1-(4,4,4-trifluorobutyl)benzimidazole-5-carboximidamide
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|
C23H21F4N5O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0564665
|
1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]-5'-chlorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H27ClN4O
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0561782
|
1'-[[5-chloro-1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C22H18ClF4N3O
|
1
|
| 1 |
IC50 = 6.2 nM
|
|
|
|
CP0559386
|
1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]-4'-chlorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H27ClN4O
|
1
|
| 1 |
IC50 = 11.1 nM
|
|
|
|
CP0569566
|
6'-fluoro-1'-[[1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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|
C22H19F4N3O
|
1
|
| 1 |
IC50 = 37.2 nM
|
|
|
|
CP0552475
|
1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]-7'-chlorospiro[cyclopropane-1,3'-indole]-2'-one
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|
C24H27ClN4O
|
1
|
| 1 |
IC50 = 46.7 nM
|
|
|
|
CP0557691
|
2-[(6'-fluoro-2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl)methyl]-1-(4,4,4-trifluorobutyl)benzimidazole-5-carboxamide
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|
C23H20F4N4O2
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0552261
|
2-[[2-[(6'-fluoro-2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl)methyl]-1-(4,4,4-trifluorobutyl)benzimidazol-5-yl]methyl]guanidine
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|
C24H24F4N6O
|
1
|
| 1 |
IC50 = 183 nM
|
|
|
|
CP0559389
|
N-[[2-[(6'-fluoro-2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl)methyl]-1-(4,4,4-trifluorobutyl)benzimidazol-5-yl]methyl]acetamide
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|
C25H24F4N4O2
|
1
|
| 1 |
IC50 = 364.5 nM
|
|
|
|
CP0559097
|
N'-ethyl-2-[(6'-fluoro-2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl)methyl]-1-(4,4,4-trifluorobutyl)benzimidazole-5-carboximidamide
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|
C25H25F4N5O
|
1
|
| 1 |
IC50 = 640.5 nM
|
|
|
|
CP0565227
|
6'-fluoro-1'-[[5-methylsulfonyl-1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-indole]-2'-one
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|
C23H21F4N3O3S
|
1
|
| 1 |
IC50 = 1069.5 nM
|
|
|
|
CP0573772
|
2-[(6'-fluoro-2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl)methyl]-1-(4,4,4-trifluorobutyl)benzimidazole-5-carboxylic acid
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|
C23H19F4N3O3
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
