Brief Information of the Cell Line and Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
Synonyms
BTI-TN-5B1-4
BTI-TN5B1-4
BTI-Tn5B14
BTI-Tn 5B1-4
Tn-5B1-4
Tn 5B1-4
Tn5 B1-4
Tn5B1-4
TN5B14
TnH5
High Five
High 5
High-5
High5
Hi-five
Hi-5
Hi5
Tn-5
Category Spontaneously immortalized cell line
Organism
Trichoplusia ni (Cabbage looper)
Cellosaurus ID
CVCL_C190
Protein ID: PT00973 , Methionine aminopeptidase 2
Gene Name METAP2
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P50579
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000023  Protein ID: PT00973
 
Compound ID Compound Name Compound Formula
CP0405902
N-[(1R)-2-[[5-chloro-6-methyl-2-(5-pyrrolidin-1-ylpyridin-2-yl)pyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C30H39ClN8O
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0380735
N-[(1R)-2-[[5-chloro-2-(5-fluoropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C26H31ClFN7O
 1
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0525718
N-[(1R)-2-[[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C26H31Cl2N7O
 1
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0525717
N-[(1R)-2-[[5-chloro-2-[5-(dimethylamino)pyridin-2-yl]-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C28H37ClN8O
 1
1
EC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0380766
N-[(1R)-2-[[5-chloro-6-methyl-2-(5-nitropyridin-2-yl)pyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C26H31ClN8O3
 1
1
EC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0560690
N-[(1R)-2-[[5-chloro-2-(4-methoxypyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C27H34ClN7O2
 1
1
EC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0180564
4-[4-[[(1R)-2-[[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]amino]butyl]benzonitrile
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C29H28Cl2N6
 1
1
EC50 = 16000 nM
   TI
   LI
   LO
   TS
CP0559150
N-[(1R)-2-[[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-2-phenylacetamide
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C26H23Cl2N5O
 1
1
EC50 = 28000 nM
   TI
   LI
   LO
   TS
CP0374970
(1R)-N'-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N-(6-phenylhexyl)ethane-1,2-diamine
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C30H33Cl2N5
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0380765
N-[(1R)-2-[[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-6-phenylhexanamide
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C30H31Cl2N5O
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0380768
N-[(1R)-2-[[5-chloro-2-(6-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C26H31Cl2N7O
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0432353
N-[(1R)-2-[[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-3-phenylpropanamide
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C27H25Cl2N5O
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0491567
N-[(1R)-2-[[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-4-phenylbutanamide
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C28H27Cl2N5O
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0508647
N-[(1R)-2-[[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-5-phenylpentanamide
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C29H29Cl2N5O
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0508648
N-[(1R)-2-[[5-chloro-2-(6-methoxypyridin-2-yl)-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C27H34ClN7O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0536154
(1R)-N-benzyl-N'-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenylethane-1,2-diamine
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C25H23Cl2N5
 1
1
EC50 = 31000 nM
   TI
   LI
   LO
   TS
CP0527474
N-[(1R)-2-[[2-(5-bromopyridin-2-yl)-5-chloro-6-methylpyrimidin-4-yl]amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide
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C26H31BrClN7O
 1
1
EC50 = 53000 nM
   TI
   LI
   LO
   TS
CP0394881
(1R)-N'-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N-(4-phenylbutyl)ethane-1,2-diamine
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C28H29Cl2N5
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0515315
(1R)-N'-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N-(5-phenylpentyl)ethane-1,2-diamine
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C29H31Cl2N5
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0515316
(1R)-N'-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N-(2-phenylethyl)ethane-1,2-diamine
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C26H25Cl2N5
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0527473
(1R)-N'-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N-(4-pyrrol-1-ylbutyl)ethane-1,2-diamine
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C26H28Cl2N6
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0057298
5-chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
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C18H17ClN4
 1
1
IC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0563103
N-[(1R)-2-[(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-2-piperazin-1-ylethanesulfonamide
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C24H30ClN7O2S
 1
1
IC50 = 9400 nM
   TI
   LI
   LO
   TS
CP0508649
N-benzyl-5-chloro-N,6-dimethyl-2-pyridin-2-ylpyrimidin-4-amine
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C18H17ClN4
 1
1
IC50 = 13000 nM
   TI
   LI
   LO
   TS
CP0397165
5-chloro-N,6-dimethyl-2-pyridin-2-ylpyrimidin-4-amine
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C11H11ClN4
 1
1
IC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0394883
N-[(1R)-2-[(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-3-piperazin-1-ylpropanamide
   Show/Hide
C25H30ClN7O
 1
1
IC50 = 22000 nM
   TI
   LI
   LO
   TS
CP0508651
5-fluoro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
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C18H17FN4
 1
1
IC50 = 62000 nM
   TI
   LI
   LO
   TS
CP0432354
N-[(1R)-2-[(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonamide
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C26H34ClN7O3S
 1
1
IC50 = 95000 nM
   TI
   LI
   LO
   TS
CP0110262
N'-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine
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C18H16ClF3N6
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0380769
N'-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-N-[6-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine
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C18H16ClF3N6
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0380770
6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
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C18H18N4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0397166
N-benzyl-5-chloro-6-methyl-2-pyridin-3-ylpyrimidin-4-amine
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C17H15ClN4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0508650
4-benzylsulfanyl-5-chloro-6-methyl-2-pyridin-2-ylpyrimidine
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C17H14ClN3S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0525367
5-chloro-N-[1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]-6-methyl-2-pyridin-2-ylpyrimidin-4-amine
   Show/Hide
C21H19Cl2F3N6
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0529612
5-chloro-4-methyl-6-(2-phenylethylsulfanyl)-2-pyridin-2-ylpyrimidine
   Show/Hide
C18H16ClN3S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0559151
5,6-dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
   Show/Hide
C19H20N4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0563104
2-[4-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)piperazin-1-yl]ethanol
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C16H20ClN5O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS