| Compound ID |
Compound Name |
Compound Formula |
|
CP0243255
|
US10239843, Example 162
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|
C23H25N5O4S3
|
1
|
| 1 |
EC50 = 9.2 nM
|
|
|
|
CP0476897
|
US10239843, Example 170
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|
C23H26N6O4S2
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0536296
|
US10239843, Example 156
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|
C21H24N4O4S2
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
|
CP0365220
|
PDD00017273 (4)
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|
C23H26N6O4S2
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0164488
|
US10239843, Example 197
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|
C21H24N4O5S
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0082747
|
US10239843, Example 174
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|
C21H25N5O4S
|
1
|
| 1 |
EC50 = 56 nM
|
|
|
|
CP0082750
|
US10239843, Example 198
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|
C20H20N4O5S
|
1
|
| 1 |
EC50 = 76 nM
|
|
|
|
CP0197811
|
US10239843, Example 291
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|
C19H23N5O4S
|
2
|
| 1 |
EC50 = 78 nM
|
|
|
| 2 |
IC50 = 80 nM
|
|
|
|
CP0360288
|
US10239843, Example 161
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|
C20H20N4O4S2
|
1
|
| 1 |
EC50 = 82 nM
|
|
|
|
CP0243254
|
US10239843, Example 173
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|
C23H27N7O4S
|
1
|
| 1 |
EC50 = 88 nM
|
|
|
|
CP0082748
|
US10239843, Example 304
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|
C19H22N4O5S
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0082752
|
1-Ethyl-N-(1-methylcyclopropyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide
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|
C18H21N5O4S2
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0230964
|
US10239843, Example 207
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|
C23H26N6O5S
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0243253
|
US10239843, Example 178
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|
C20H21N5O4S
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0079145
|
US10239843, Example 39
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|
C16H17N3O4S
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0168929
|
US10239843, Example 297
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|
C21H25N5O5S
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0255486
|
1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide
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|
C22H25N7O4S2
|
1
|
| 1 |
EC50 = 270 nM
|
|
|
|
CP0405435
|
US10239843, Example 194
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|
C17H16N4O4S
|
1
|
| 1 |
EC50 = 270 nM
|
|
|
|
CP0116460
|
US10239843, Example 305
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|
C21H24N4O6S
|
1
|
| 1 |
EC50 = 280 nM
|
|
|
|
CP0230975
|
US10239843, Example 192
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|
C20H22N6O4S
|
1
|
| 1 |
EC50 = 560 nM
|
|
|
|
CP0255478
|
US10239843, Example 23
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|
C17H21N3O4S
|
1
|
| 1 |
EC50 = 620 nM
|
|
|
|
CP0243242
|
US10239843, Example 4
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|
C16H21N3O4S
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0405436
|
US10239843, Example 193
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|
C18H20N4O4S
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0257820
|
US10239843, Example 2
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|
C14H17N3O4S
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0243245
|
US10239843, Example 8
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|
C20H21N3O4S
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0079146
|
US10239843, Example 34
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|
C20H27N3O4S
|
1
|
| 1 |
EC50 = 2700 nM
|
|
|
|
CP0164481
|
US10239843, Example 9
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|
C15H19N3O4S
|
1
|
| 1 |
EC50 = 3600 nM
|
|
|
|
CP0569791
|
US10239843, Example 5
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|
C16H18N4O4S
|
1
|
| 1 |
EC50 = 5600 nM
|
|
|
|
CP0079144
|
US10239843, Example 25
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|
C16H21N3O5S
|
1
|
| 1 |
EC50 = 6100 nM
|
|
|
|
CP0082731
|
US10239843, Example 26
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|
C17H24N4O4S
|
1
|
| 1 |
EC50 = 6400 nM
|
|
|
|
CP0079138
|
N-(1-methylcyclopropyl)-9,10-dioxoanthracene-2-sulfonamide
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|
C18H15NO4S
|
1
|
| 1 |
EC50 = 6600 nM
|
|
|
|
CP0082730
|
3-Methyl-N-(1-methylcyclopropyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
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|
C13H15N3O4S
|
1
|
| 1 |
EC50 = 8100 nM
|
|
|
|
CP0243244
|
US10239843, Example 175
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|
C15H16N4O4S
|
1
|
| 1 |
EC50 = 8900 nM
|
|
|
|
CP0458051
|
US10239843, Example 3
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|
C14H14N4O4S
|
1
|
| 1 |
EC50 = 14000 nM
|
|
|
|
CP0079139
|
N-(1-cyanocyclopropyl)-9,10-dioxoanthracene-2-sulfonamide
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|
C18H12N2O4S
|
1
|
| 1 |
EC50 = 19000 nM
|
|
|
|
CP0079137
|
N-cyclopropyl-9,10-dioxoanthracene-2-sulfonamide
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|
C17H13NO4S
|
1
|
| 1 |
EC50 = 22000 nM
|
|
|
|
CP0230129
|
PDD00013907 (1)
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|
C18H17NO4S
|
1
|
| 1 |
EC50 = 30000 nM
|
|
|
|
CP0519217
|
1-[(1-methylpyrazol-3-yl)methyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-N-[1-(trideuteriomethyl)cyclopropyl]quinazoline-6-sulfonamide
Show/Hide
|
C22H25N7O4S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0519215
|
1-Ethyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide
Show/Hide
|
C19H22FN5O4S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0423252
|
N-(1-methylcyclopropyl)-1-[(1-methylpyrazol-3-yl)methyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxoquinazoline-6-sulfonamide
Show/Hide
|
C22H25N7O4S
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0477071
|
N-[1-(fluoromethyl)cyclopropyl]-1-[(1-methylpyrazol-3-yl)methyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxoquinazoline-6-sulfonamide
Show/Hide
|
C22H24FN7O4S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0468991
|
N-[1-(Fluoromethyl)cyclopropyl]-1-methyl-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide
Show/Hide
|
C18H20FN5O4S
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0230973
|
US10239843, Example 155
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|
C18H21N5O4S
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0423251
|
N-[1-(difluoromethyl)cyclopropyl]-1-[(1-methylpyrazol-3-yl)methyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxoquinazoline-6-sulfonamide
Show/Hide
|
C22H23F2N7O4S
|
1
|
| 1 |
IC50 = 1250 nM
|
|
|
|
CP0468992
|
1-[(1-methylpyrazol-3-yl)methyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-N-[1-(trifluoromethyl)cyclopropyl]quinazoline-6-sulfonamide
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|
C22H22F3N7O4S
|
1
|
| 1 |
IC50 = 4100 nM
|
|
|
|
CP0477070
|
1-ethyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(5-methyl-1,2-oxazol-3-yl)methyl]-2,4-dioxoquinazoline-6-sulfonamide
Show/Hide
|
C19H21FN4O5S
|
1
|
| 1 |
IC50 = 6600 nM
|
|
|
