| Compound ID |
Compound Name |
Compound Formula |
|
CP0436072
|
2-[2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5-methyl-11-methylsulfonylpyrimido[4,5-b][1,4]benzodiazepin-6-one
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|
C32H40N8O5S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0579131
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-[2-[(4-methylpiperazin-1-yl)methyl]pyrimidin-5-yl]-1H-pyrrole-2-carboxamide
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|
C22H21Cl2FN6O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0579555
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-[6-[(1-methylpiperidin-4-yl)methyl]pyridin-3-yl]-1H-pyrrole-2-carboxamide
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|
C24H23Cl2FN4O2
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0568064
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-[2-[(1-methylpiperidin-4-yl)amino]pyrimidin-5-yl]-1H-pyrrole-2-carboxamide
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|
C22H21Cl2FN6O2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0577393
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-[6-(1-methylpiperidin-4-yl)oxypyridin-3-yl]-1H-pyrrole-2-carboxamide
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|
C23H21Cl2FN4O3
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0577392
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-[2-(piperazin-1-ylmethyl)pyrimidin-5-yl]-1H-pyrrole-2-carboxamide
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|
C21H19Cl2FN6O2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0377465
|
11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C26H31N7O2
|
2
|
| 1 |
IC50 = 66 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
|
CP0551933
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-[6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]-1H-pyrrole-2-carboxamide
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|
C23H22Cl2FN5O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0491701
|
11-cyclobutyl-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5-methylpyrimido[4,5-b][1,4]benzodiazepin-6-one
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|
C28H33N7O2
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0051871
|
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C25H29N7O2
|
2
|
| 1 |
IC50 = 87 nM
|
|
|
| 2 |
IC50 = 190 nM
|
|
|
|
CP0380419
|
11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C27H33N7O2
|
2
|
| 1 |
IC50 = 98 nM
|
|
|
| 2 |
IC50 = 230 nM
|
|
|
|
CP0404446
|
2-((2-methoxy-4-(4-(pyrrolidin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C30H35N7O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0570478
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-(1-methylpyrazol-4-yl)-1H-pyrrole-2-carboxamide
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|
C16H11Cl2FN4O2
|
1
|
| 1 |
IC50 = 141 nM
|
|
|
|
CP0473882
|
11-cyclopentyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C29H35N7O2
|
2
|
| 1 |
IC50 = 146 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
|
CP0454393
|
2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C30H38N8O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0535040
|
11-butan-2-yl-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5-methylpyrimido[4,5-b][1,4]benzodiazepin-6-one
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|
C28H35N7O2
|
1
|
| 1 |
IC50 = 222 nM
|
|
|
|
CP0404445
|
2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]-pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C24H27N7O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0074960
|
2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C26H30N6O3
|
2
|
| 1 |
IC50 = 240 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
|
CP0365412
|
2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)amino-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C25H28N6O3
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0404447
|
4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)-N-(2-(dimethylamino)ethyl)-3-methoxybenzamide
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|
C25H29N7O3
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0404448
|
2-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C26H30N6O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0454361
|
2-((2-methoxy-4-morpholinophenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C24H26N6O3
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0363540
|
N-[4-[(5,11-dimethyl-6-oxopyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]-3-methoxyphenyl]methanesulfonamide
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|
C21H22N6O4S
|
1
|
| 1 |
IC50 = 276 nM
|
|
|
|
CP0404450
|
5,11-dimethyl-2-((2-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Show/Hide
|
C25H29N7O
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0395994
|
4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)benzenesulfonamide
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|
C19H18N6O3S
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0357714
|
4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Show/Hide
|
C27H31N7O3
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0473027
|
4-[(5-ethyl-11-methyl-6-oxopyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Show/Hide
|
C28H33N7O3
|
1
|
| 1 |
IC50 = 482 nM
|
|
|
|
CP0570111
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-[1-(piperidin-4-ylmethyl)pyrazol-4-yl]-1H-pyrrole-2-carboxamide
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|
C21H20Cl2FN5O2
|
1
|
| 1 |
IC50 = 671 nM
|
|
|
|
CP0570110
|
4-(3,6-dichloro-2-fluorobenzoyl)-N-(1-piperidin-4-ylpyrazol-4-yl)-1H-pyrrole-2-carboxamide
Show/Hide
|
C20H18Cl2FN5O2
|
1
|
| 1 |
IC50 = 787 nM
|
|
|
|
CP0437474
|
9-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Show/Hide
|
C25H28ClN7O2
|
2
|
| 1 |
IC50 = 1138 nM
|
|
|
| 2 |
IC50 = 11380 nM
|
|
|
|
CP0085569
|
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Show/Hide
|
C24H27N7O2
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0266619
|
5-ethyl-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-11-methylpyrimido[4,5-b][1,4]benzodiazepin-6-one
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|
C26H31N7O2
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
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CP0465764
|
8-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Show/Hide
|
C25H28ClN7O2
|
1
|
| 1 |
IC50 = 1240 nM
|
|
|
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CP0454394
|
9-fluoro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C25H28FN7O2
|
1
|
| 1 |
IC50 = 1320 nM
|
|
|
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CP0380420
|
2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,8,11-trimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
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|
C26H31N7O2
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
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CP0437475
|
2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-11-methyl-5-(2,2,2-trifluoroethyl)pyrimido[4,5-b][1,4]benzodiazepin-6-one
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|
C26H28F3N7O2
|
1
|
| 1 |
IC50 = 3350 nM
|
|
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CP0473026
|
2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-4,5,11-trimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one
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|
C26H31N7O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
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