General Information of the Compound
Compound ID
CP0404447
Compound Name
4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)-N-(2-(dimethylamino)ethyl)-3-methoxybenzamide
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Structure
Formula
C25H29N7O3
Molecular Weight
475.553
Canonical SMILES
COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)C(=O)NCCN(C)C
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InChI
InChI=1S/C25H29N7O3/c1-30(2)13-12-26-23(33)16-10-11-18(21(14-16)35-5)28-25-27-15-20-22(29-25)31(3)19-9-7-6-8-17(19)24(34)32(20)4/h6-11,14-15H,12-13H2,1-5H3,(H,26,33)(H,27,28,29)
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InChIKey
GIYVCQVJJYRKEE-UHFFFAOYSA-N
Physicochemical Property
logP
2.8781
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
102.93
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53326949
ChEMBL ID
CHEMBL1673050
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02105, Mitogen-activated protein kinase 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 240 nM
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